A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells

Sweating is an important physiological process to regulate body temperature in humans, and various disorders are associated with dysregulated sweat formation. Primary sweat secretion in human eccrine sweat glands involves Ca2+‐activated Cl− channels (CaCC). Recently, members of the TMEM16 family wer...

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Veröffentlicht in:	Experimental dermatology 2014-11, Vol.23 (11), p.825-831
Hauptverfasser:	Ertongur-Fauth, Torsten, Hochheimer, Andreas, Buescher, Joerg Martin, Rapprich, Stefan, Krohn, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Anoctamin-1 Calcium - chemistry calcium-activated chloride channel Chloride Channels - genetics Chloride Channels - metabolism Chlorides - chemistry Eccrine Glands - metabolism Epithelial Cells - metabolism Humans hyperhidrosis Molecular Sequence Data NCL-SG3 Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Protein Multimerization Protein Structure, Tertiary Skin - metabolism Sweat - metabolism sweat gland Sweat Glands - metabolism TMEM16A
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