Effects of sildenafil on nanostructural and nanomechanical changes in mitochondria in an ischaemia-reperfusion rat model

Summary Sildenafil exerts cardioprotective effects by activating the opening of mitochondrial ATP‐sensitive potassium channels to attenuate ischaemia–reperfusion (IR) injury. In the present study, we used atomic force microscopy (AFM) to investigate changes in mitochondrial morphology and properties...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2014-10, Vol.41 (10), p.763-768
Hauptverfasser:	Lee, Kyung Hye, Kwon, Sung Jin, Woo, Jong-Shin, Lee, Gi-Ja, Lee, So-Ra, Jang, Hyun-Hee, Kim, Hyun Soo, Kim, Jung Wook, Park, Hun Kuk, Cho, Kyu Seok, Kim, Weon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atomic force microscopy ischaemia-reperfusion injury mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Mitochondrial Swelling - drug effects Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - metabolism myocardial preconditioning Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardium - metabolism Myocardium - ultrastructure Piperazines - pharmacology Potassium Channels - metabolism Purines - pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - metabolism sildenafil Sildenafil Citrate Sulfonamides - pharmacology
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