Calcium and ethanol-induced gastric mucosal damage in rats
The effects of graded doses of ethanol on stomach mucosal damage and calcium levels were studied in rats. The influence of verapamil and/or calcium chloride on these changes was also investigated. Orally administered ethanol (20, 50 or 80% v/v) markedly decreased gastric glandular tissue calcium and...
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| Veröffentlicht in: | Pharmacological research 1991, Vol.23 (1), p.71-79 |
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| creator | Wong, S.H. Cho, C.H. Ogle, C.W. |
| description | The effects of graded doses of ethanol on stomach mucosal damage and calcium levels were studied in rats. The influence of verapamil and/or calcium chloride on these changes was also investigated. Orally administered ethanol (20, 50 or 80% v/v) markedly decreased gastric glandular tissue calcium and it concentration dependently produced mucosal lesions. Pretreatment with verapamil (2.5 or 5 mg/kg, i.p.) dose dependently lessened glandular wall calcium levels and worsened ethanol-induced mucosal damage. Calcium chloride (50 mg/kg, i.p.) significantly prevented ethanol-induced gastric calcium depletion; it also dose dependently antagonized the damaging effect of ethanol as well as the lesion-intensifying action of verapamil. The findings that verapamil potentiated, whereas calcium chloride prevented, ethanol-induced glandular mucosal damage and tissue calcium changes indeed suggest that altered gastric cell calcium levels could be closely related to the mucosal lesions produced by ethanol in rats. |
| doi_str_mv | 10.1016/S1043-6618(05)80108-2 |
| format | Article |
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The influence of verapamil and/or calcium chloride on these changes was also investigated. Orally administered ethanol (20, 50 or 80% v/v) markedly decreased gastric glandular tissue calcium and it concentration dependently produced mucosal lesions. Pretreatment with verapamil (2.5 or 5 mg/kg, i.p.) dose dependently lessened glandular wall calcium levels and worsened ethanol-induced mucosal damage. Calcium chloride (50 mg/kg, i.p.) significantly prevented ethanol-induced gastric calcium depletion; it also dose dependently antagonized the damaging effect of ethanol as well as the lesion-intensifying action of verapamil. The findings that verapamil potentiated, whereas calcium chloride prevented, ethanol-induced glandular mucosal damage and tissue calcium changes indeed suggest that altered gastric cell calcium levels could be closely related to the mucosal lesions produced by ethanol in rats.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/S1043-6618(05)80108-2</identifier><identifier>PMID: 2047361</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; calcium ; Calcium - metabolism ; Calcium - pharmacology ; calcium chloride ; Ethanol ; gastric lesions ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Male ; Medical sciences ; Rats ; Rats, Inbred Strains ; Stomach Ulcer - chemically induced ; Toxicology ; verapamil ; Verapamil - pharmacology</subject><ispartof>Pharmacological research, 1991, Vol.23 (1), p.71-79</ispartof><rights>1991 The Italian Pharmacological Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-d551e5fca07f02afdad89b6d528df3c7524ff1c6c22b692a2719d665456395073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1043-6618(05)80108-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19474302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2047361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, S.H.</creatorcontrib><creatorcontrib>Cho, C.H.</creatorcontrib><creatorcontrib>Ogle, C.W.</creatorcontrib><title>Calcium and ethanol-induced gastric mucosal damage in rats</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>The effects of graded doses of ethanol on stomach mucosal damage and calcium levels were studied in rats. The influence of verapamil and/or calcium chloride on these changes was also investigated. Orally administered ethanol (20, 50 or 80% v/v) markedly decreased gastric glandular tissue calcium and it concentration dependently produced mucosal lesions. Pretreatment with verapamil (2.5 or 5 mg/kg, i.p.) dose dependently lessened glandular wall calcium levels and worsened ethanol-induced mucosal damage. Calcium chloride (50 mg/kg, i.p.) significantly prevented ethanol-induced gastric calcium depletion; it also dose dependently antagonized the damaging effect of ethanol as well as the lesion-intensifying action of verapamil. The findings that verapamil potentiated, whereas calcium chloride prevented, ethanol-induced glandular mucosal damage and tissue calcium changes indeed suggest that altered gastric cell calcium levels could be closely related to the mucosal lesions produced by ethanol in rats.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium - pharmacology</subject><subject>calcium chloride</subject><subject>Ethanol</subject><subject>gastric lesions</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Toxicology</subject><subject>verapamil</subject><subject>Verapamil - pharmacology</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKxEAQhhtRxvURhFwUPUSrOulO4kVkcAPBg3puanrRlizanQi-vZmZoEdPVfAvVXyMHSKcIaA8f0LIs1RKLE9AnJaAUKZ8g-0gVDJFLOXmcp8s22w3xncAqHKEGZtxyItM4g67mFOt_dAk1JrE9m_UdnXqWzNoa5JXin3wOmkG3UWqE0MNvdrEt0mgPu6zLUd1tAfT3GMvN9fP87v04fH2fn71kOq8LPrUCIFWOE1QOODkDJmyWkgjeGlcpgvBc-dQS835QlaceIGVkVLkQmaVgCLbY8fr3o_QfQ429qrxUdu6ptZ2Q1QoscIM5WgUa6MOXYzBOvURfEPhWyGoJTO1YqaWQBQItWKm-Jg7nA4Mi8aa39QEadSPJp2iptoFarWPf-VVXuQZLHsu1z470vjyNqiovW1Hkj5Y3SvT-X8--QF2Tobo</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Wong, S.H.</creator><creator>Cho, C.H.</creator><creator>Ogle, C.W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1991</creationdate><title>Calcium and ethanol-induced gastric mucosal damage in rats</title><author>Wong, S.H. ; Cho, C.H. ; Ogle, C.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-d551e5fca07f02afdad89b6d528df3c7524ff1c6c22b692a2719d665456395073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium - pharmacology</topic><topic>calcium chloride</topic><topic>Ethanol</topic><topic>gastric lesions</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Toxicology</topic><topic>verapamil</topic><topic>Verapamil - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, S.H.</creatorcontrib><creatorcontrib>Cho, C.H.</creatorcontrib><creatorcontrib>Ogle, C.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, S.H.</au><au>Cho, C.H.</au><au>Ogle, C.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium and ethanol-induced gastric mucosal damage in rats</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>1991</date><risdate>1991</risdate><volume>23</volume><issue>1</issue><spage>71</spage><epage>79</epage><pages>71-79</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>The effects of graded doses of ethanol on stomach mucosal damage and calcium levels were studied in rats. The influence of verapamil and/or calcium chloride on these changes was also investigated. Orally administered ethanol (20, 50 or 80% v/v) markedly decreased gastric glandular tissue calcium and it concentration dependently produced mucosal lesions. Pretreatment with verapamil (2.5 or 5 mg/kg, i.p.) dose dependently lessened glandular wall calcium levels and worsened ethanol-induced mucosal damage. Calcium chloride (50 mg/kg, i.p.) significantly prevented ethanol-induced gastric calcium depletion; it also dose dependently antagonized the damaging effect of ethanol as well as the lesion-intensifying action of verapamil. The findings that verapamil potentiated, whereas calcium chloride prevented, ethanol-induced glandular mucosal damage and tissue calcium changes indeed suggest that altered gastric cell calcium levels could be closely related to the mucosal lesions produced by ethanol in rats.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>2047361</pmid><doi>10.1016/S1043-6618(05)80108-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pharmacological research, 1991, Vol.23 (1), p.71-79 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences calcium Calcium - metabolism Calcium - pharmacology calcium chloride Ethanol gastric lesions Gastric Mucosa - drug effects Gastric Mucosa - metabolism Male Medical sciences Rats Rats, Inbred Strains Stomach Ulcer - chemically induced Toxicology verapamil Verapamil - pharmacology |
| title | Calcium and ethanol-induced gastric mucosal damage in rats |
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