The effects of dimethylated and alkylated polycyclic aromatic hydrocarbons on the embryonic development of the Japanese medaka
The Japanese medaka (Oryzias latipes) early-life stage assay was used to investigate the effects of a number of commercially available dimethylated polycyclic aromatic hydrocarbons (PAHs) (3,6-dimethylphenanthrene, 7,12-dimethylbenz[a]anthracene, and 4,6-dimethyldibenzothiophene) and their unsubstit...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 2005-03, Vol.60 (3), p.247-258 |
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| creator | Rhodes, Spencer Farwell, Andrea Mark Hewitt, L. MacKinnon, Michael George Dixon, D. |
| description | The Japanese medaka (Oryzias latipes) early-life stage assay was used to investigate the effects of a number of commercially available dimethylated polycyclic aromatic hydrocarbons (PAHs) (3,6-dimethylphenanthrene, 7,12-dimethylbenz[a]anthracene, and 4,6-dimethyldibenzothiophene) and their unsubstituted congeners, dimethylated and unsubstituted tertiary mixtures, and a complex environmental mixture (with elevated C2-substituted dibenzothiophene) on embryo larval development. Unsubstituted PAHs showed trends of increased blue sac disease (BSD) relative to dimethylated PAHs, although the severity of BSD induction varied. Results demonstrated that the dibenzothiophene congeners were the strongest inducers of BSD of the commercial PAHs tested. These compounds reduced the hatching success of embryonic medaka, an effect that was enhanced in the mixture. The base neutral extract significantly increased the frequency and severity of BSD abnormalities, while significantly reducing larval hatch length. Based on these results, a sublethal maximum allowable toxicant concentration (MATC) of 13.91μg PAHs/L was calculated. |
| doi_str_mv | 10.1016/j.ecoenv.2004.08.002 |
| format | Article |
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Unsubstituted PAHs showed trends of increased blue sac disease (BSD) relative to dimethylated PAHs, although the severity of BSD induction varied. Results demonstrated that the dibenzothiophene congeners were the strongest inducers of BSD of the commercial PAHs tested. These compounds reduced the hatching success of embryonic medaka, an effect that was enhanced in the mixture. The base neutral extract significantly increased the frequency and severity of BSD abnormalities, while significantly reducing larval hatch length. Based on these results, a sublethal maximum allowable toxicant concentration (MATC) of 13.91μg PAHs/L was calculated.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/j.ecoenv.2004.08.002</identifier><identifier>PMID: 15590001</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animal, plant and microbial ecology ; Animals ; Applied ecology ; bioassays ; Biological and medical sciences ; Blue sac disease ; Dibenzothiophene ; Dimethyl-polycyclic aromatic hydrocarbons ; Ecotoxicology, biological effects of pollution ; Embryo, Nonmammalian - drug effects ; embryogenesis ; embryotoxicity ; Fish Diseases - chemically induced ; Fish Diseases - embryology ; Fish Diseases - pathology ; fish larvae ; Fishes ; Freshwater ; Fundamental and applied biological sciences. Psychology ; General aspects ; hydrocarbons ; Japanese medaka ; Larva - drug effects ; Oryzias ; Oryzias latipes ; petroleum ; Petroleum hydrocarbons ; polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - chemistry ; Polycyclic Aromatic Hydrocarbons - toxicity ; Thiophenes - toxicity ; Water Pollutants, Chemical - toxicity</subject><ispartof>Ecotoxicology and environmental safety, 2005-03, Vol.60 (3), p.247-258</ispartof><rights>2004</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-f630a7c1ea948c6125d57fdb077e0a0d1f955a386ce58fc6af80088cc8229d543</citedby><cites>FETCH-LOGICAL-c511t-f630a7c1ea948c6125d57fdb077e0a0d1f955a386ce58fc6af80088cc8229d543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ecoenv.2004.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16558512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15590001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rhodes, Spencer</creatorcontrib><creatorcontrib>Farwell, Andrea</creatorcontrib><creatorcontrib>Mark Hewitt, L.</creatorcontrib><creatorcontrib>MacKinnon, Michael</creatorcontrib><creatorcontrib>George Dixon, D.</creatorcontrib><title>The effects of dimethylated and alkylated polycyclic aromatic hydrocarbons on the embryonic development of the Japanese medaka</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>The Japanese medaka (Oryzias latipes) early-life stage assay was used to investigate the effects of a number of commercially available dimethylated polycyclic aromatic hydrocarbons (PAHs) (3,6-dimethylphenanthrene, 7,12-dimethylbenz[a]anthracene, and 4,6-dimethyldibenzothiophene) and their unsubstituted congeners, dimethylated and unsubstituted tertiary mixtures, and a complex environmental mixture (with elevated C2-substituted dibenzothiophene) on embryo larval development. Unsubstituted PAHs showed trends of increased blue sac disease (BSD) relative to dimethylated PAHs, although the severity of BSD induction varied. Results demonstrated that the dibenzothiophene congeners were the strongest inducers of BSD of the commercial PAHs tested. These compounds reduced the hatching success of embryonic medaka, an effect that was enhanced in the mixture. The base neutral extract significantly increased the frequency and severity of BSD abnormalities, while significantly reducing larval hatch length. Based on these results, a sublethal maximum allowable toxicant concentration (MATC) of 13.91μg PAHs/L was calculated.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Blue sac disease</subject><subject>Dibenzothiophene</subject><subject>Dimethyl-polycyclic aromatic hydrocarbons</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>embryogenesis</subject><subject>embryotoxicity</subject><subject>Fish Diseases - chemically induced</subject><subject>Fish Diseases - embryology</subject><subject>Fish Diseases - pathology</subject><subject>fish larvae</subject><subject>Fishes</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>hydrocarbons</subject><subject>Japanese medaka</subject><subject>Larva - drug effects</subject><subject>Oryzias</subject><subject>Oryzias latipes</subject><subject>petroleum</subject><subject>Petroleum hydrocarbons</subject><subject>polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - chemistry</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Thiophenes - toxicity</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpabZp_0FpfWlvdka2ZcuXQgn9JJBDk7OYlUZdb2zLlbwLvuS3R8aG3HoQ0qBnXkaPGHvPIePAq6tjRtrRcM5ygDIDmQHkL9iOQwNpXvLyJdsBL-u0Ery4YG9COAJAAUK8ZhdciCZWfMce7w6UkLWkp5A4m5i2p-kwdziRSXCIq3vYqtF1s5511-oEvetxiofDbLzT6PduiO1DMi1p_d7Pboi3hs7UubGnYVqyl8vfOOJAgZKeDD7gW_bKYhfo3bZfsvvv3-6uf6Y3tz9-XX-9SbXgfEptVQDWmhM2pdQVz4URtTV7qGsCBMNtIwQWstIkpNUVWgkgpdYyzxsjyuKSfV5zR-_-nShMqm-Dpq6Lw7hTULzisskrGcFyBbV3IXiyavRtj35WHNTiXR3V6l0t3hVIFb3Htg9b_mkfX_bctImOwKcNwKCxsx4H3YZnrhJCCr4EfVw5i07hXx-Z-z95DAAOhYgaIvFlJSj6OrfkVdAtDZpM6-MvKuPa_8_6BGrBrg4</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Rhodes, Spencer</creator><creator>Farwell, Andrea</creator><creator>Mark Hewitt, L.</creator><creator>MacKinnon, Michael</creator><creator>George Dixon, D.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20050301</creationdate><title>The effects of dimethylated and alkylated polycyclic aromatic hydrocarbons on the embryonic development of the Japanese medaka</title><author>Rhodes, Spencer ; Farwell, Andrea ; Mark Hewitt, L. ; MacKinnon, Michael ; George Dixon, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-f630a7c1ea948c6125d57fdb077e0a0d1f955a386ce58fc6af80088cc8229d543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Blue sac disease</topic><topic>Dibenzothiophene</topic><topic>Dimethyl-polycyclic aromatic hydrocarbons</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Embryo, Nonmammalian - drug effects</topic><topic>embryogenesis</topic><topic>embryotoxicity</topic><topic>Fish Diseases - chemically induced</topic><topic>Fish Diseases - embryology</topic><topic>Fish Diseases - pathology</topic><topic>fish larvae</topic><topic>Fishes</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>hydrocarbons</topic><topic>Japanese medaka</topic><topic>Larva - drug effects</topic><topic>Oryzias</topic><topic>Oryzias latipes</topic><topic>petroleum</topic><topic>Petroleum hydrocarbons</topic><topic>polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - chemistry</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Thiophenes - toxicity</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhodes, Spencer</creatorcontrib><creatorcontrib>Farwell, Andrea</creatorcontrib><creatorcontrib>Mark Hewitt, L.</creatorcontrib><creatorcontrib>MacKinnon, Michael</creatorcontrib><creatorcontrib>George Dixon, D.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhodes, Spencer</au><au>Farwell, Andrea</au><au>Mark Hewitt, L.</au><au>MacKinnon, Michael</au><au>George Dixon, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of dimethylated and alkylated polycyclic aromatic hydrocarbons on the embryonic development of the Japanese medaka</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>60</volume><issue>3</issue><spage>247</spage><epage>258</epage><pages>247-258</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>The Japanese medaka (Oryzias latipes) early-life stage assay was used to investigate the effects of a number of commercially available dimethylated polycyclic aromatic hydrocarbons (PAHs) (3,6-dimethylphenanthrene, 7,12-dimethylbenz[a]anthracene, and 4,6-dimethyldibenzothiophene) and their unsubstituted congeners, dimethylated and unsubstituted tertiary mixtures, and a complex environmental mixture (with elevated C2-substituted dibenzothiophene) on embryo larval development. Unsubstituted PAHs showed trends of increased blue sac disease (BSD) relative to dimethylated PAHs, although the severity of BSD induction varied. Results demonstrated that the dibenzothiophene congeners were the strongest inducers of BSD of the commercial PAHs tested. These compounds reduced the hatching success of embryonic medaka, an effect that was enhanced in the mixture. The base neutral extract significantly increased the frequency and severity of BSD abnormalities, while significantly reducing larval hatch length. Based on these results, a sublethal maximum allowable toxicant concentration (MATC) of 13.91μg PAHs/L was calculated.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>15590001</pmid><doi>10.1016/j.ecoenv.2004.08.002</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animal, plant and microbial ecology Animals Applied ecology bioassays Biological and medical sciences Blue sac disease Dibenzothiophene Dimethyl-polycyclic aromatic hydrocarbons Ecotoxicology, biological effects of pollution Embryo, Nonmammalian - drug effects embryogenesis embryotoxicity Fish Diseases - chemically induced Fish Diseases - embryology Fish Diseases - pathology fish larvae Fishes Freshwater Fundamental and applied biological sciences. Psychology General aspects hydrocarbons Japanese medaka Larva - drug effects Oryzias Oryzias latipes petroleum Petroleum hydrocarbons polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - chemistry Polycyclic Aromatic Hydrocarbons - toxicity Thiophenes - toxicity Water Pollutants, Chemical - toxicity |
| title | The effects of dimethylated and alkylated polycyclic aromatic hydrocarbons on the embryonic development of the Japanese medaka |
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