Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis
Introduction Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness...
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| Veröffentlicht in: | Journal of endocrinological investigation 2014-08, Vol.37 (8), p.765-768 |
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| creator | Tuna, Mazhar Müslüm Imga, Narin Nasıroğlu Doğan, Berçem Ayçiçek Yılmaz, Fatma Meriç Topçuoğlu, Canan Akbaba, Gülhan Berker, Dilek Güler, Serdar |
| description | Introduction
Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness (CIMT) in patients with non-functioning AI (NFAI).
Materials and methods
This study included data from 28 patients with NFAI (Group 1) and 41 controls (Group 2). Of the patients, 50 were female and 19 were male, and the mean age was 46.7 (range 37–65) years.
Results
There were no significant differences between Group 1 and 2 in terms of age, sex, or BMI. Hypertension prevalence was significantly higher in the NFAI group than in the control group (
p
= 0.01). Both groups had similar lipid, blood glucose, homocysteine, uric acid, high-sensitivity CRP levels. Adiponectin, leptin, and resistin levels were similar in both groups. CIMTs were significantly higher in the NFAI group.
Conclusion
There is increasing evidence that several cardiometabolic risk factors occur with higher prevalence in non-functioning adrenal incidentaloma patients compared to age-matched healthy subjects. In our study, hypertension prevalence and CIMT were higher in the NFAI group. Serum adipokine levels were similar for both groups. |
| doi_str_mv | 10.1007/s40618-014-0106-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1618829024</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1618829024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-4ab8088aceca4bc179b2d3a527253dbba471433f37cf70959bc44264b315b64b3</originalsourceid><addsrcrecordid>eNp9kE2LFDEQhoMo7of-AC-So5de89WT9FEWV4VFL3oOlXT1TNaeZEx1Kwv-eDPMrnjykKoUeeolPIy9kuJKCmHfkhEb6TohTTti0_VP2Lm0SnROu83Tf-5n7ILoTghttbPP2Zkyg9JucOfs9-eSu2nNcUklp7zlMFbMMPOUYxoxLzCXPRCHihyISkyw4Mh_pWXHd2m7w8p39wesC2ZqCfxQ8SfMmGPD8_iI1ETfeZk4LG0qFOdjTfSCPZtgJnz50C_Zt5v3X68_drdfPny6fnfbRW3M0hkITjgHESOYEKUdgho19MqqXo8hgLHSaD1pGycrhn4I0Ri1MUHLPhzbJXtzyj3U8mNFWvw-UcR5hoxlJS-bRacGoUxD5QmN7YdUcfKHmvZQ770U_ijdn6T7Jt0fpfu-7bx-iF_DHse_G4-WG6BOALWnvMXq78pam2X6T-ofDQaPtQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1618829024</pqid></control><display><type>article</type><title>Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tuna, Mazhar Müslüm ; Imga, Narin Nasıroğlu ; Doğan, Berçem Ayçiçek ; Yılmaz, Fatma Meriç ; Topçuoğlu, Canan ; Akbaba, Gülhan ; Berker, Dilek ; Güler, Serdar</creator><creatorcontrib>Tuna, Mazhar Müslüm ; Imga, Narin Nasıroğlu ; Doğan, Berçem Ayçiçek ; Yılmaz, Fatma Meriç ; Topçuoğlu, Canan ; Akbaba, Gülhan ; Berker, Dilek ; Güler, Serdar</creatorcontrib><description>Introduction
Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness (CIMT) in patients with non-functioning AI (NFAI).
Materials and methods
This study included data from 28 patients with NFAI (Group 1) and 41 controls (Group 2). Of the patients, 50 were female and 19 were male, and the mean age was 46.7 (range 37–65) years.
Results
There were no significant differences between Group 1 and 2 in terms of age, sex, or BMI. Hypertension prevalence was significantly higher in the NFAI group than in the control group (
p
= 0.01). Both groups had similar lipid, blood glucose, homocysteine, uric acid, high-sensitivity CRP levels. Adiponectin, leptin, and resistin levels were similar in both groups. CIMTs were significantly higher in the NFAI group.
Conclusion
There is increasing evidence that several cardiometabolic risk factors occur with higher prevalence in non-functioning adrenal incidentaloma patients compared to age-matched healthy subjects. In our study, hypertension prevalence and CIMT were higher in the NFAI group. Serum adipokine levels were similar for both groups.</description><identifier>ISSN: 1720-8386</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-014-0106-5</identifier><identifier>PMID: 24923898</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adipokines - blood ; Adrenal Gland Neoplasms - blood ; Adrenal Gland Neoplasms - immunology ; Adrenal Gland Neoplasms - metabolism ; Adrenal Gland Neoplasms - physiopathology ; Adult ; Aged ; Atherosclerosis - epidemiology ; Atherosclerosis - etiology ; C-Reactive Protein - analysis ; Carotid Intima-Media Thickness ; Endocrinology ; Female ; Homocysteine - blood ; Hospitals, Teaching ; Humans ; Hypertension - epidemiology ; Hypertension - etiology ; Insulin Resistance ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - etiology ; Middle Aged ; Original Article ; Prevalence ; Risk Factors ; Turkey - epidemiology</subject><ispartof>Journal of endocrinological investigation, 2014-08, Vol.37 (8), p.765-768</ispartof><rights>Italian Society of Endocrinology (SIE) 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-4ab8088aceca4bc179b2d3a527253dbba471433f37cf70959bc44264b315b64b3</citedby><cites>FETCH-LOGICAL-c344t-4ab8088aceca4bc179b2d3a527253dbba471433f37cf70959bc44264b315b64b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-014-0106-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-014-0106-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24923898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuna, Mazhar Müslüm</creatorcontrib><creatorcontrib>Imga, Narin Nasıroğlu</creatorcontrib><creatorcontrib>Doğan, Berçem Ayçiçek</creatorcontrib><creatorcontrib>Yılmaz, Fatma Meriç</creatorcontrib><creatorcontrib>Topçuoğlu, Canan</creatorcontrib><creatorcontrib>Akbaba, Gülhan</creatorcontrib><creatorcontrib>Berker, Dilek</creatorcontrib><creatorcontrib>Güler, Serdar</creatorcontrib><title>Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Introduction
Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness (CIMT) in patients with non-functioning AI (NFAI).
Materials and methods
This study included data from 28 patients with NFAI (Group 1) and 41 controls (Group 2). Of the patients, 50 were female and 19 were male, and the mean age was 46.7 (range 37–65) years.
Results
There were no significant differences between Group 1 and 2 in terms of age, sex, or BMI. Hypertension prevalence was significantly higher in the NFAI group than in the control group (
p
= 0.01). Both groups had similar lipid, blood glucose, homocysteine, uric acid, high-sensitivity CRP levels. Adiponectin, leptin, and resistin levels were similar in both groups. CIMTs were significantly higher in the NFAI group.
Conclusion
There is increasing evidence that several cardiometabolic risk factors occur with higher prevalence in non-functioning adrenal incidentaloma patients compared to age-matched healthy subjects. In our study, hypertension prevalence and CIMT were higher in the NFAI group. Serum adipokine levels were similar for both groups.</description><subject>Adipokines - blood</subject><subject>Adrenal Gland Neoplasms - blood</subject><subject>Adrenal Gland Neoplasms - immunology</subject><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adrenal Gland Neoplasms - physiopathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Atherosclerosis - epidemiology</subject><subject>Atherosclerosis - etiology</subject><subject>C-Reactive Protein - analysis</subject><subject>Carotid Intima-Media Thickness</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Hospitals, Teaching</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - etiology</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Turkey - epidemiology</subject><issn>1720-8386</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7of-AC-So5de89WT9FEWV4VFL3oOlXT1TNaeZEx1Kwv-eDPMrnjykKoUeeolPIy9kuJKCmHfkhEb6TohTTti0_VP2Lm0SnROu83Tf-5n7ILoTghttbPP2Zkyg9JucOfs9-eSu2nNcUklp7zlMFbMMPOUYxoxLzCXPRCHihyISkyw4Mh_pWXHd2m7w8p39wesC2ZqCfxQ8SfMmGPD8_iI1ETfeZk4LG0qFOdjTfSCPZtgJnz50C_Zt5v3X68_drdfPny6fnfbRW3M0hkITjgHESOYEKUdgho19MqqXo8hgLHSaD1pGycrhn4I0Ri1MUHLPhzbJXtzyj3U8mNFWvw-UcR5hoxlJS-bRacGoUxD5QmN7YdUcfKHmvZQ770U_ijdn6T7Jt0fpfu-7bx-iF_DHse_G4-WG6BOALWnvMXq78pam2X6T-ofDQaPtQ</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Tuna, Mazhar Müslüm</creator><creator>Imga, Narin Nasıroğlu</creator><creator>Doğan, Berçem Ayçiçek</creator><creator>Yılmaz, Fatma Meriç</creator><creator>Topçuoğlu, Canan</creator><creator>Akbaba, Gülhan</creator><creator>Berker, Dilek</creator><creator>Güler, Serdar</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis</title><author>Tuna, Mazhar Müslüm ; Imga, Narin Nasıroğlu ; Doğan, Berçem Ayçiçek ; Yılmaz, Fatma Meriç ; Topçuoğlu, Canan ; Akbaba, Gülhan ; Berker, Dilek ; Güler, Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-4ab8088aceca4bc179b2d3a527253dbba471433f37cf70959bc44264b315b64b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipokines - blood</topic><topic>Adrenal Gland Neoplasms - blood</topic><topic>Adrenal Gland Neoplasms - immunology</topic><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Adrenal Gland Neoplasms - physiopathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Atherosclerosis - epidemiology</topic><topic>Atherosclerosis - etiology</topic><topic>C-Reactive Protein - analysis</topic><topic>Carotid Intima-Media Thickness</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Hospitals, Teaching</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - etiology</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - etiology</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuna, Mazhar Müslüm</creatorcontrib><creatorcontrib>Imga, Narin Nasıroğlu</creatorcontrib><creatorcontrib>Doğan, Berçem Ayçiçek</creatorcontrib><creatorcontrib>Yılmaz, Fatma Meriç</creatorcontrib><creatorcontrib>Topçuoğlu, Canan</creatorcontrib><creatorcontrib>Akbaba, Gülhan</creatorcontrib><creatorcontrib>Berker, Dilek</creatorcontrib><creatorcontrib>Güler, Serdar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuna, Mazhar Müslüm</au><au>Imga, Narin Nasıroğlu</au><au>Doğan, Berçem Ayçiçek</au><au>Yılmaz, Fatma Meriç</au><au>Topçuoğlu, Canan</au><au>Akbaba, Gülhan</au><au>Berker, Dilek</au><au>Güler, Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>37</volume><issue>8</issue><spage>765</spage><epage>768</epage><pages>765-768</pages><issn>1720-8386</issn><eissn>1720-8386</eissn><abstract>Introduction
Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness (CIMT) in patients with non-functioning AI (NFAI).
Materials and methods
This study included data from 28 patients with NFAI (Group 1) and 41 controls (Group 2). Of the patients, 50 were female and 19 were male, and the mean age was 46.7 (range 37–65) years.
Results
There were no significant differences between Group 1 and 2 in terms of age, sex, or BMI. Hypertension prevalence was significantly higher in the NFAI group than in the control group (
p
= 0.01). Both groups had similar lipid, blood glucose, homocysteine, uric acid, high-sensitivity CRP levels. Adiponectin, leptin, and resistin levels were similar in both groups. CIMTs were significantly higher in the NFAI group.
Conclusion
There is increasing evidence that several cardiometabolic risk factors occur with higher prevalence in non-functioning adrenal incidentaloma patients compared to age-matched healthy subjects. In our study, hypertension prevalence and CIMT were higher in the NFAI group. Serum adipokine levels were similar for both groups.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>24923898</pmid><doi>10.1007/s40618-014-0106-5</doi><tpages>4</tpages></addata></record> |
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| subjects | Adipokines - blood Adrenal Gland Neoplasms - blood Adrenal Gland Neoplasms - immunology Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - physiopathology Adult Aged Atherosclerosis - epidemiology Atherosclerosis - etiology C-Reactive Protein - analysis Carotid Intima-Media Thickness Endocrinology Female Homocysteine - blood Hospitals, Teaching Humans Hypertension - epidemiology Hypertension - etiology Insulin Resistance Male Medicine Medicine & Public Health Metabolic Diseases Metabolic Syndrome - epidemiology Metabolic Syndrome - etiology Middle Aged Original Article Prevalence Risk Factors Turkey - epidemiology |
| title | Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis |
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