Kinetic Intermediates in Amyloid Assembly

In contrast to an expected Ostwald-like ripening of amyloid assemblies, the nucleating core of the Dutch mutant of the Aβ peptide of Alzheimer’s disease assembles through a series of conformational transitions. Structural characterization of the intermediate assemblies by isotope-edited IR and solid...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2014-10, Vol.136 (43), p.15146-15149
Hauptverfasser:	Liang, Chen, Ni, Rong, Smith, Jillian E, Childers, W. Seth, Mehta, Anil K, Lynn, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid beta-Peptides - chemistry Kinetics Models, Molecular Protein Aggregates Protein Structure, Secondary
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!