Conformational changes associated with post-translational modifications of Pro(143) in Skp1 of Dictyostelium--a dipeptide model system

Prolyl hydroxylation and subsequent glycosylation of the E3(SCF) ubiquitin ligase subunit Skp1 affects its conformation and its interaction with F-box proteins and, ultimately, O2-sensing in the organism. Taking a reductionist approach to understand the molecular basis for these effects, a series of...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-10, Vol.136 (43), p.15170-15175
Hauptverfasser:	Karunaratne, Chamini V, Weldeghiorghis, Thomas K, West, Christopher M, Taylor, Carol M
Format:	Artikel
Sprache:	eng
Schlagworte:	Dictyostelium Dipeptides - metabolism F-Box Proteins - metabolism Proline - metabolism Protein Conformation Protein Isoforms - chemistry Protein Isoforms - metabolism Protein Processing, Post-Translational Protozoan Proteins - chemistry Protozoan Proteins - metabolism S-Phase Kinase-Associated Proteins - chemistry S-Phase Kinase-Associated Proteins - metabolism
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