Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

In patients with Huntington's disease (HD), the protein huntingtin (Htt) has an expanded polyglutamine (poly-Q) tract. HD results in early loss of medium spiny neurons in the striatum, which impairs motor and cognitive functions. Identifying the physiological role and molecular functions of Htt...

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Veröffentlicht in:	Science signaling 2014-10, Vol.7 (349), p.ra103-ra103
Hauptverfasser:	Pryor, William M, Biagioli, Marta, Shahani, Neelam, Swarnkar, Supriya, Huang, Wen-Chin, Page, Damon T, MacDonald, Marcy E, Subramaniam, Srinivasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line, Tumor Cell Size Corpus Striatum - cytology Corpus Striatum - metabolism Corpus Striatum - pathology Genetic Vectors - genetics HEK293 Cells Humans Huntingtin Protein Huntington Disease - metabolism Huntington Disease - physiopathology Kaplan-Meier Estimate Mechanistic Target of Rapamycin Complex 1 Mice Monomeric GTP-Binding Proteins - metabolism Multiprotein Complexes - metabolism Nerve Tissue Proteins - metabolism Neuropeptides - metabolism Ras Homolog Enriched in Brain Protein RNA, Small Interfering - genetics Rotarod Performance Test Signal Transduction - physiology Statistics, Nonparametric TOR Serine-Threonine Kinases - metabolism
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