Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyl-transferase of Neurospora crassa
Serine hydroxymethyl-transferase (SHMT) occupies a central position in one-carbon (C sub(1)) metabolism, catalyzing the reaction of serine and tetrahydrofolate to yield glycine and 5,10-methylene-tetrahydrofolate. Methylene-tetrahydrofolate serves as a donor of C sub(1) units for the synthesis of nu...
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| Veröffentlicht in: | Molecular and cellular biology 1992-01, Vol.12 (4), p.1412-1421 |
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| container_title | Molecular and cellular biology |
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| creator | McClung, C R Davis, C R Page, K M Denome, SA |
| description | Serine hydroxymethyl-transferase (SHMT) occupies a central position in one-carbon (C sub(1)) metabolism, catalyzing the reaction of serine and tetrahydrofolate to yield glycine and 5,10-methylene-tetrahydrofolate. Methylene-tetrahydrofolate serves as a donor of C sub(1) units for the synthesis of numerous compounds, including purines, thymidylate, lipids, and methionine. We provide evidence that the formate (for) locus of Neurospora crassa) encodes cytosolic SHMT. The for super(+) gene encodes a polypeptide of 479 amino acids which shows significant similarity to amino acid sequences of SHMT from bacterial and mammalian sources (47 and 60% amino acid identity, respectively). The for super(+) mRNA has several different start and stop sites. |
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Methylene-tetrahydrofolate serves as a donor of C sub(1) units for the synthesis of numerous compounds, including purines, thymidylate, lipids, and methionine. We provide evidence that the formate (for) locus of Neurospora crassa) encodes cytosolic SHMT. The for super(+) gene encodes a polypeptide of 479 amino acids which shows significant similarity to amino acid sequences of SHMT from bacterial and mammalian sources (47 and 60% amino acid identity, respectively). 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The for super(+) mRNA has several different start and stop sites.</description><subject>amino acid sequence</subject><subject>for super(+) gene</subject><subject>genes</subject><subject>Neurospora crassa</subject><subject>nucleotide sequence</subject><subject>phosphoribosylglycinamide formyltransferase</subject><subject>predictions</subject><issn>0270-7306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqNjMFqAjEQhnOwoG19hzlJC12Ija72LJaeeupdhjhLItmMzmTR9eCzd1v6AD39Hz8f38hM7OvKVitn67G5Vz1Ya-s36ybmtgko6AtJvGKJnIEbKIGgYWmxEDwN8AyJfacvcA7RB6DseU_6q_m-sHKKHnRIZILQ74UvfUsl9KkqglkbElT6CX9SJ6xHFgQ_fIqP5q7BpDT92wcze99-bT6qo_CpIy27NqqnlDATd7qb1_P1wi2d-7f4DX2hU7g</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>McClung, C R</creator><creator>Davis, C R</creator><creator>Page, K M</creator><creator>Denome, SA</creator><scope>7QL</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19920101</creationdate><title>Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyl-transferase of Neurospora crassa</title><author>McClung, C R ; Davis, C R ; Page, K M ; Denome, SA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_161843533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>amino acid sequence</topic><topic>for super(+) gene</topic><topic>genes</topic><topic>Neurospora crassa</topic><topic>nucleotide sequence</topic><topic>phosphoribosylglycinamide formyltransferase</topic><topic>predictions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McClung, C R</creatorcontrib><creatorcontrib>Davis, C R</creatorcontrib><creatorcontrib>Page, K M</creatorcontrib><creatorcontrib>Denome, SA</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Molecular and cellular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McClung, C R</au><au>Davis, C R</au><au>Page, K M</au><au>Denome, SA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyl-transferase of Neurospora crassa</atitle><jtitle>Molecular and cellular biology</jtitle><date>1992-01-01</date><risdate>1992</risdate><volume>12</volume><issue>4</issue><spage>1412</spage><epage>1421</epage><pages>1412-1421</pages><issn>0270-7306</issn><abstract>Serine hydroxymethyl-transferase (SHMT) occupies a central position in one-carbon (C sub(1)) metabolism, catalyzing the reaction of serine and tetrahydrofolate to yield glycine and 5,10-methylene-tetrahydrofolate. Methylene-tetrahydrofolate serves as a donor of C sub(1) units for the synthesis of numerous compounds, including purines, thymidylate, lipids, and methionine. We provide evidence that the formate (for) locus of Neurospora crassa) encodes cytosolic SHMT. The for super(+) gene encodes a polypeptide of 479 amino acids which shows significant similarity to amino acid sequences of SHMT from bacterial and mammalian sources (47 and 60% amino acid identity, respectively). The for super(+) mRNA has several different start and stop sites.</abstract></addata></record> |
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| ispartof | Molecular and cellular biology, 1992-01, Vol.12 (4), p.1412-1421 |
| issn | 0270-7306 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | amino acid sequence for super(+) gene genes Neurospora crassa nucleotide sequence phosphoribosylglycinamide formyltransferase predictions |
| title | Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyl-transferase of Neurospora crassa |
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