The effect of α-MSH on fever caused by Staphylococcus aureus cell walls in rabbits
The role of endogenous pyrogens induced by gram-positive bacterial pyrogens is not known. Intravenous α-MSH (2.5 μg) significantly reduced only the first phase of the biphasic thermal response to IV S. aureus cell walls (5 × 10 7). Intracerebroventricular α-MSH (200 ng) had no effect on the fever re...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1991-11, Vol.12 (6), p.1239-1242 |
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| creator | Goelst, K. Laburn, H. |
| description | The role of endogenous pyrogens induced by gram-positive bacterial pyrogens is not known. Intravenous α-MSH (2.5 μg) significantly reduced only the first phase of the biphasic thermal response to IV
S. aureus cell walls (5 × 10
7). Intracerebroventricular α-MSH (200 ng) had no effect on the fever response. The fall in serum iron concentration was significantly attenuated by the IV α-MSH but was not affected by the ICV α-MSH. Intravenous α-MSH had no effect on fever or the serum iron response caused by muramyl dipeptide (MDP). We conclude that the first phase of the thermal response to
S. aureus cell walls is mediated by an endogenous pyrogen (EP) and the second phase of the response by a mechanism not involving EP, but possibly a muramyl peptide. |
| doi_str_mv | 10.1016/0196-9781(91)90201-Y |
| format | Article |
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S. aureus cell walls (5 × 10
7). Intracerebroventricular α-MSH (200 ng) had no effect on the fever response. The fall in serum iron concentration was significantly attenuated by the IV α-MSH but was not affected by the ICV α-MSH. Intravenous α-MSH had no effect on fever or the serum iron response caused by muramyl dipeptide (MDP). We conclude that the first phase of the thermal response to
S. aureus cell walls is mediated by an endogenous pyrogen (EP) and the second phase of the response by a mechanism not involving EP, but possibly a muramyl peptide.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(91)90201-Y</identifier><identifier>PMID: 1667687</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylmuramyl-Alanyl-Isoglutamine - toxicity ; alpha-MSH - administration & dosage ; alpha-MSH - pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antipyresis ; Biological and medical sciences ; Cell Wall ; Fever ; Fever - blood ; Fever - etiology ; Fever - prevention & control ; Fundamental and applied biological sciences. Psychology ; Injections, Intravenous ; Injections, Intraventricular ; Iron - blood ; Muramyl dipeptide ; Pyrogens - toxicity ; Rabbit ; Rabbits ; S. aureus ; Staphylococcus aureus ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; α-Melanocyte stimulating hormone</subject><ispartof>Peptides (New York, N.Y. : 1980), 1991-11, Vol.12 (6), p.1239-1242</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7fefeca39665b6dd3b20c860866e3328b9cbe9f21d7ea4f651c81f896afdacd23</citedby><cites>FETCH-LOGICAL-c417t-7fefeca39665b6dd3b20c860866e3328b9cbe9f21d7ea4f651c81f896afdacd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/019697819190201Y$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5089141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1667687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goelst, K.</creatorcontrib><creatorcontrib>Laburn, H.</creatorcontrib><title>The effect of α-MSH on fever caused by Staphylococcus aureus cell walls in rabbits</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>The role of endogenous pyrogens induced by gram-positive bacterial pyrogens is not known. Intravenous α-MSH (2.5 μg) significantly reduced only the first phase of the biphasic thermal response to IV
S. aureus cell walls (5 × 10
7). Intracerebroventricular α-MSH (200 ng) had no effect on the fever response. The fall in serum iron concentration was significantly attenuated by the IV α-MSH but was not affected by the ICV α-MSH. Intravenous α-MSH had no effect on fever or the serum iron response caused by muramyl dipeptide (MDP). We conclude that the first phase of the thermal response to
S. aureus cell walls is mediated by an endogenous pyrogen (EP) and the second phase of the response by a mechanism not involving EP, but possibly a muramyl peptide.</description><subject>Acetylmuramyl-Alanyl-Isoglutamine - toxicity</subject><subject>alpha-MSH - administration & dosage</subject><subject>alpha-MSH - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antipyresis</subject><subject>Biological and medical sciences</subject><subject>Cell Wall</subject><subject>Fever</subject><subject>Fever - blood</subject><subject>Fever - etiology</subject><subject>Fever - prevention & control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intravenous</subject><subject>Injections, Intraventricular</subject><subject>Iron - blood</subject><subject>Muramyl dipeptide</subject><subject>Pyrogens - toxicity</subject><subject>Rabbit</subject><subject>Rabbits</subject><subject>S. aureus</subject><subject>Staphylococcus aureus</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>Time Factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>α-Melanocyte stimulating hormone</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9qGzEQh0VocB2nb5CCDqUkh200u2utdCkUk3-Q0IPdQ05CK42IynrXlXZd_Fh5kTxTtNi4t8LAHOabmR8fIRfAvgEDfs1A8kxWAi4lXEmWM8ieT8gURFVkc-DyA5kekY_kLMbfjLGylGJCJsB5xUU1JcvVC1J0Dk1PO0ffXrOn5T3tWupwi4EaPUS0tN7RZa83L7umM50xQ6R6CJiawaahf3XTROpbGnRd-z6ek1Onm4ifDn1Gft3erBb32ePPu4fFj8fMlFD1WeUwvdWF5Hxec2uLOmdGcCY4x6LIRS1NjdLlYCvUpeNzMAKckFw7q43Nixn5ur-7Cd2fAWOv1j6OiXSL3RAVcBBlUcgElnvQhC7GgE5tgl_rsFPA1OhSjaLUKErJVKNL9ZzWPh_uD_Ua7b-lvbw0_3KY62h044JujY9HbM6EhBIS9n2PYXKx9RhUNB5bg9aHpF3Zzv8_xzs9GJEJ</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Goelst, K.</creator><creator>Laburn, H.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19911101</creationdate><title>The effect of α-MSH on fever caused by Staphylococcus aureus cell walls in rabbits</title><author>Goelst, K. ; Laburn, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7fefeca39665b6dd3b20c860866e3328b9cbe9f21d7ea4f651c81f896afdacd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetylmuramyl-Alanyl-Isoglutamine - toxicity</topic><topic>alpha-MSH - administration & dosage</topic><topic>alpha-MSH - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antipyresis</topic><topic>Biological and medical sciences</topic><topic>Cell Wall</topic><topic>Fever</topic><topic>Fever - blood</topic><topic>Fever - etiology</topic><topic>Fever - prevention & control</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intravenous</topic><topic>Injections, Intraventricular</topic><topic>Iron - blood</topic><topic>Muramyl dipeptide</topic><topic>Pyrogens - toxicity</topic><topic>Rabbit</topic><topic>Rabbits</topic><topic>S. aureus</topic><topic>Staphylococcus aureus</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Time Factors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>α-Melanocyte stimulating hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goelst, K.</creatorcontrib><creatorcontrib>Laburn, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goelst, K.</au><au>Laburn, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of α-MSH on fever caused by Staphylococcus aureus cell walls in rabbits</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>12</volume><issue>6</issue><spage>1239</spage><epage>1242</epage><pages>1239-1242</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>The role of endogenous pyrogens induced by gram-positive bacterial pyrogens is not known. Intravenous α-MSH (2.5 μg) significantly reduced only the first phase of the biphasic thermal response to IV
S. aureus cell walls (5 × 10
7). Intracerebroventricular α-MSH (200 ng) had no effect on the fever response. The fall in serum iron concentration was significantly attenuated by the IV α-MSH but was not affected by the ICV α-MSH. Intravenous α-MSH had no effect on fever or the serum iron response caused by muramyl dipeptide (MDP). We conclude that the first phase of the thermal response to
S. aureus cell walls is mediated by an endogenous pyrogen (EP) and the second phase of the response by a mechanism not involving EP, but possibly a muramyl peptide.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1667687</pmid><doi>10.1016/0196-9781(91)90201-Y</doi><tpages>4</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 1991-11, Vol.12 (6), p.1239-1242 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylmuramyl-Alanyl-Isoglutamine - toxicity alpha-MSH - administration & dosage alpha-MSH - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antipyresis Biological and medical sciences Cell Wall Fever Fever - blood Fever - etiology Fever - prevention & control Fundamental and applied biological sciences. Psychology Injections, Intravenous Injections, Intraventricular Iron - blood Muramyl dipeptide Pyrogens - toxicity Rabbit Rabbits S. aureus Staphylococcus aureus Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems α-Melanocyte stimulating hormone |
| title | The effect of α-MSH on fever caused by Staphylococcus aureus cell walls in rabbits |
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