An electrophysiological classification associated with Guillain–Barré syndrome outcomes
Guillain–Barré syndrome (GBS) is an acute, post-infectious, inflammatory, autoimmune peripheral neuropathy with a highly diverse clinical course and outcome. We classified GBS on the basis of patients’ first nerve conduction and validated this system to be associated with outcome on the basis of ele...
Gespeichert in:
| Veröffentlicht in: | Journal of neurology 2014-10, Vol.261 (10), p.1986-1993 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1993 |
|---|---|
| container_issue | 10 |
| container_start_page | 1986 |
| container_title | Journal of neurology |
| container_volume | 261 |
| creator | Hosokawa, Takafumi Nakajima, Hideto Unoda, Kiichi Yamane, Kazushi Doi, Yoshimitsu Ishida, Shimon Kimura, Fumiharu Hanafusa, Toshiaki |
| description | Guillain–Barré syndrome (GBS) is an acute, post-infectious, inflammatory, autoimmune peripheral neuropathy with a highly diverse clinical course and outcome. We classified GBS on the basis of patients’ first nerve conduction and validated this system to be associated with outcome on the basis of electrophysiological characteristics during the acute phase of GBS. We retrospectively evaluated 40 GBS patients who underwent their first electrophysiological study within 14 days of onset and classified GBS into four patterns: (1) acute inflammatory demyelinating polyneuropathy (AIDP) pattern with sensory nerve conduction abnormalities (motor–sensory AIDP: MS-AIDP), (2) AIDP pattern without sensory nerve conduction abnormalities (motor AIDP: M-AIDP), (3) acute motor axonal neuropathy (AMAN) pattern, and (4) minor abnormalities pattern. We compared the clinical, electrophysiological, and laboratory findings between groups and determined subgroups associated with poor outcome. The MS-AIDP and AMAN patterns more frequently exhibited prolonged recovery compared with the M-AIDP and minor abnormalities patterns and were associated with prolonged recovery (specificity, 100 %; sensitivity, 73 %;
P
|
| doi_str_mv | 10.1007/s00415-014-7452-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1618161126</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1618161126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3902-8bee6d7dfa0b51daf76688bbb58e84d4eb3a8ee8ca8f6ca7151e12dfeee87b403</originalsourceid><addsrcrecordid>eNqNkc9KxDAQxoMo7rr6AF6k4MVLdZImbfa4iv9A8KIXLyFNp5ql26xJi-zNd_ApfA7fxCcxy6qIIHgIk8z85sskHyG7FA4pQHEUADgVKVCeFlywlK2RIeUZSykX43UyhIxDKjLBB2QrhCkAyFjYJAMmQLKcjYfkbtIm2KDpvJs_LIJ1jbu3RjeJaXQIto77zro2iQdnrO6wSp5s95Cc97ZptG3fn1-Otfdvr0lYtJV3M0xc35kYwzbZqHUTcOczjsjt2enNyUV6dX1-eTK5Sk02BpbKEjGviqrWUApa6brIcynLshQSJa84lpmWiNJoWedGF1RQpKyqMeaKkkM2Igcr3bl3jz2GTs1sMBjHa9H1QdGcyrgoy_-DQpEzDjSi-7_Qqet9Gx8SKRjHf2RySdEVZbwLwWOt5t7OtF8oCmrpkVp5pKJHaumRYrFn71O5L2dYfXd8mRIBtgJCLLX36H9c_afqB8mLn0Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1609459281</pqid></control><display><type>article</type><title>An electrophysiological classification associated with Guillain–Barré syndrome outcomes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hosokawa, Takafumi ; Nakajima, Hideto ; Unoda, Kiichi ; Yamane, Kazushi ; Doi, Yoshimitsu ; Ishida, Shimon ; Kimura, Fumiharu ; Hanafusa, Toshiaki</creator><creatorcontrib>Hosokawa, Takafumi ; Nakajima, Hideto ; Unoda, Kiichi ; Yamane, Kazushi ; Doi, Yoshimitsu ; Ishida, Shimon ; Kimura, Fumiharu ; Hanafusa, Toshiaki</creatorcontrib><description>Guillain–Barré syndrome (GBS) is an acute, post-infectious, inflammatory, autoimmune peripheral neuropathy with a highly diverse clinical course and outcome. We classified GBS on the basis of patients’ first nerve conduction and validated this system to be associated with outcome on the basis of electrophysiological characteristics during the acute phase of GBS. We retrospectively evaluated 40 GBS patients who underwent their first electrophysiological study within 14 days of onset and classified GBS into four patterns: (1) acute inflammatory demyelinating polyneuropathy (AIDP) pattern with sensory nerve conduction abnormalities (motor–sensory AIDP: MS-AIDP), (2) AIDP pattern without sensory nerve conduction abnormalities (motor AIDP: M-AIDP), (3) acute motor axonal neuropathy (AMAN) pattern, and (4) minor abnormalities pattern. We compared the clinical, electrophysiological, and laboratory findings between groups and determined subgroups associated with poor outcome. The MS-AIDP and AMAN patterns more frequently exhibited prolonged recovery compared with the M-AIDP and minor abnormalities patterns and were associated with prolonged recovery (specificity, 100 %; sensitivity, 73 %;
P
< 0.001). The period of inability to walk independently was significantly longer in the MS-AIDP and AMAN patterns than in the M-AIDP and minor abnormalities patterns (median 85 vs. 10 days;
P
< 0.001). In conclusion, our classification of GBS using a single nerve conduction study in the early phase of disease is associated with outcomes. This classification can be used to counsel individual patients and guide decision-making with respect to treatment.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-014-7452-2</identifier><identifier>PMID: 25082629</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Diabetes ; Diabetic neuropathy ; Electric Stimulation ; Electrophysiology ; Evoked Potentials, Motor - physiology ; Female ; Guillain-Barre syndrome ; Guillain-Barre Syndrome - classification ; Guillain-Barre Syndrome - physiopathology ; Humans ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neural Conduction - physiology ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Physiology ; Retrospective Studies ; Sensitivity and Specificity ; Statistics, Nonparametric ; Time Factors ; Young Adult</subject><ispartof>Journal of neurology, 2014-10, Vol.261 (10), p.1986-1993</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3902-8bee6d7dfa0b51daf76688bbb58e84d4eb3a8ee8ca8f6ca7151e12dfeee87b403</citedby><cites>FETCH-LOGICAL-c3902-8bee6d7dfa0b51daf76688bbb58e84d4eb3a8ee8ca8f6ca7151e12dfeee87b403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-014-7452-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-014-7452-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25082629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosokawa, Takafumi</creatorcontrib><creatorcontrib>Nakajima, Hideto</creatorcontrib><creatorcontrib>Unoda, Kiichi</creatorcontrib><creatorcontrib>Yamane, Kazushi</creatorcontrib><creatorcontrib>Doi, Yoshimitsu</creatorcontrib><creatorcontrib>Ishida, Shimon</creatorcontrib><creatorcontrib>Kimura, Fumiharu</creatorcontrib><creatorcontrib>Hanafusa, Toshiaki</creatorcontrib><title>An electrophysiological classification associated with Guillain–Barré syndrome outcomes</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Guillain–Barré syndrome (GBS) is an acute, post-infectious, inflammatory, autoimmune peripheral neuropathy with a highly diverse clinical course and outcome. We classified GBS on the basis of patients’ first nerve conduction and validated this system to be associated with outcome on the basis of electrophysiological characteristics during the acute phase of GBS. We retrospectively evaluated 40 GBS patients who underwent their first electrophysiological study within 14 days of onset and classified GBS into four patterns: (1) acute inflammatory demyelinating polyneuropathy (AIDP) pattern with sensory nerve conduction abnormalities (motor–sensory AIDP: MS-AIDP), (2) AIDP pattern without sensory nerve conduction abnormalities (motor AIDP: M-AIDP), (3) acute motor axonal neuropathy (AMAN) pattern, and (4) minor abnormalities pattern. We compared the clinical, electrophysiological, and laboratory findings between groups and determined subgroups associated with poor outcome. The MS-AIDP and AMAN patterns more frequently exhibited prolonged recovery compared with the M-AIDP and minor abnormalities patterns and were associated with prolonged recovery (specificity, 100 %; sensitivity, 73 %;
P
< 0.001). The period of inability to walk independently was significantly longer in the MS-AIDP and AMAN patterns than in the M-AIDP and minor abnormalities patterns (median 85 vs. 10 days;
P
< 0.001). In conclusion, our classification of GBS using a single nerve conduction study in the early phase of disease is associated with outcomes. This classification can be used to counsel individual patients and guide decision-making with respect to treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Diabetes</subject><subject>Diabetic neuropathy</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Guillain-Barre syndrome</subject><subject>Guillain-Barre Syndrome - classification</subject><subject>Guillain-Barre Syndrome - physiopathology</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neural Conduction - physiology</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Physiology</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Statistics, Nonparametric</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkc9KxDAQxoMo7rr6AF6k4MVLdZImbfa4iv9A8KIXLyFNp5ql26xJi-zNd_ApfA7fxCcxy6qIIHgIk8z85sskHyG7FA4pQHEUADgVKVCeFlywlK2RIeUZSykX43UyhIxDKjLBB2QrhCkAyFjYJAMmQLKcjYfkbtIm2KDpvJs_LIJ1jbu3RjeJaXQIto77zro2iQdnrO6wSp5s95Cc97ZptG3fn1-Otfdvr0lYtJV3M0xc35kYwzbZqHUTcOczjsjt2enNyUV6dX1-eTK5Sk02BpbKEjGviqrWUApa6brIcynLshQSJa84lpmWiNJoWedGF1RQpKyqMeaKkkM2Igcr3bl3jz2GTs1sMBjHa9H1QdGcyrgoy_-DQpEzDjSi-7_Qqet9Gx8SKRjHf2RySdEVZbwLwWOt5t7OtF8oCmrpkVp5pKJHaumRYrFn71O5L2dYfXd8mRIBtgJCLLX36H9c_afqB8mLn0Y</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Hosokawa, Takafumi</creator><creator>Nakajima, Hideto</creator><creator>Unoda, Kiichi</creator><creator>Yamane, Kazushi</creator><creator>Doi, Yoshimitsu</creator><creator>Ishida, Shimon</creator><creator>Kimura, Fumiharu</creator><creator>Hanafusa, Toshiaki</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>An electrophysiological classification associated with Guillain–Barré syndrome outcomes</title><author>Hosokawa, Takafumi ; Nakajima, Hideto ; Unoda, Kiichi ; Yamane, Kazushi ; Doi, Yoshimitsu ; Ishida, Shimon ; Kimura, Fumiharu ; Hanafusa, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3902-8bee6d7dfa0b51daf76688bbb58e84d4eb3a8ee8ca8f6ca7151e12dfeee87b403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Diabetes</topic><topic>Diabetic neuropathy</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Guillain-Barre syndrome</topic><topic>Guillain-Barre Syndrome - classification</topic><topic>Guillain-Barre Syndrome - physiopathology</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neural Conduction - physiology</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Physiology</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Statistics, Nonparametric</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosokawa, Takafumi</creatorcontrib><creatorcontrib>Nakajima, Hideto</creatorcontrib><creatorcontrib>Unoda, Kiichi</creatorcontrib><creatorcontrib>Yamane, Kazushi</creatorcontrib><creatorcontrib>Doi, Yoshimitsu</creatorcontrib><creatorcontrib>Ishida, Shimon</creatorcontrib><creatorcontrib>Kimura, Fumiharu</creatorcontrib><creatorcontrib>Hanafusa, Toshiaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosokawa, Takafumi</au><au>Nakajima, Hideto</au><au>Unoda, Kiichi</au><au>Yamane, Kazushi</au><au>Doi, Yoshimitsu</au><au>Ishida, Shimon</au><au>Kimura, Fumiharu</au><au>Hanafusa, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An electrophysiological classification associated with Guillain–Barré syndrome outcomes</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2014-10</date><risdate>2014</risdate><volume>261</volume><issue>10</issue><spage>1986</spage><epage>1993</epage><pages>1986-1993</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Guillain–Barré syndrome (GBS) is an acute, post-infectious, inflammatory, autoimmune peripheral neuropathy with a highly diverse clinical course and outcome. We classified GBS on the basis of patients’ first nerve conduction and validated this system to be associated with outcome on the basis of electrophysiological characteristics during the acute phase of GBS. We retrospectively evaluated 40 GBS patients who underwent their first electrophysiological study within 14 days of onset and classified GBS into four patterns: (1) acute inflammatory demyelinating polyneuropathy (AIDP) pattern with sensory nerve conduction abnormalities (motor–sensory AIDP: MS-AIDP), (2) AIDP pattern without sensory nerve conduction abnormalities (motor AIDP: M-AIDP), (3) acute motor axonal neuropathy (AMAN) pattern, and (4) minor abnormalities pattern. We compared the clinical, electrophysiological, and laboratory findings between groups and determined subgroups associated with poor outcome. The MS-AIDP and AMAN patterns more frequently exhibited prolonged recovery compared with the M-AIDP and minor abnormalities patterns and were associated with prolonged recovery (specificity, 100 %; sensitivity, 73 %;
P
< 0.001). The period of inability to walk independently was significantly longer in the MS-AIDP and AMAN patterns than in the M-AIDP and minor abnormalities patterns (median 85 vs. 10 days;
P
< 0.001). In conclusion, our classification of GBS using a single nerve conduction study in the early phase of disease is associated with outcomes. This classification can be used to counsel individual patients and guide decision-making with respect to treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25082629</pmid><doi>10.1007/s00415-014-7452-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5354 |
| ispartof | Journal of neurology, 2014-10, Vol.261 (10), p.1986-1993 |
| issn | 0340-5354 1432-1459 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1618161126 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Diabetes Diabetic neuropathy Electric Stimulation Electrophysiology Evoked Potentials, Motor - physiology Female Guillain-Barre syndrome Guillain-Barre Syndrome - classification Guillain-Barre Syndrome - physiopathology Humans Kaplan-Meier Estimate Male Medicine Medicine & Public Health Middle Aged Neural Conduction - physiology Neurology Neuroradiology Neurosciences Original Communication Physiology Retrospective Studies Sensitivity and Specificity Statistics, Nonparametric Time Factors Young Adult |
| title | An electrophysiological classification associated with Guillain–Barré syndrome outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T23%3A23%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20electrophysiological%20classification%20associated%20with%20Guillain%E2%80%93Barr%C3%A9%20syndrome%20outcomes&rft.jtitle=Journal%20of%20neurology&rft.au=Hosokawa,%20Takafumi&rft.date=2014-10&rft.volume=261&rft.issue=10&rft.spage=1986&rft.epage=1993&rft.pages=1986-1993&rft.issn=0340-5354&rft.eissn=1432-1459&rft_id=info:doi/10.1007/s00415-014-7452-2&rft_dat=%3Cproquest_cross%3E1618161126%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1609459281&rft_id=info:pmid/25082629&rfr_iscdi=true |