The Urinary Antigen Tests have High Sensitivity in Diagnosis of Pneumococcus Caused Community-Acquired Pneumonia Posterior to Antimicrobial Therapy
Antibiotic treatment before microbiological test significant reduces the positive rate of culture methods of Streptococcus pneumoniae . The Binax NOW S. pneumoniae immunochromatographic test (ICT) has become a more commonly used procedure to diagnose S. pneumoniae from community-acquired pneumonia i...
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| Veröffentlicht in: | Cell biochemistry and biophysics 2014-11, Vol.70 (2), p.1029-1034 |
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| creator | Chen, Ming Zhou, Ming Xiao, Wei Ai, Biao Liu, Xuezheng Li, Yan |
| description | Antibiotic treatment before microbiological test significant reduces the positive rate of culture methods of
Streptococcus pneumoniae
. The Binax NOW
S. pneumoniae
immunochromatographic test (ICT) has become a more commonly used procedure to diagnose
S. pneumoniae
from community-acquired pneumonia in adults. However, performance of this test after empirical antimicrobial therapy is uncertain. Therefore, in this prospective study, we evaluate the impact of antimicrobial therapy on sensitivity of ICT test in 487 hospitalized adult patients. The results showed that 192 (39.4 %) and 295 (60.6 %) specimens were collected before (Group 1) or after antibiotic treatment (Group 2), respectively.
S. pneumoniae
was detected by ICT in 21 (10.9 %) patients in the Group 1 and 39 (13.2 %) in the Group 2 and their positive rates were not different (
P
> 0.05). However, The positive rate of blood and pleural fluid was declined from 5.7 to 2.7 % and sputum, from 9.9 to 4.7 % after the antibiotic treatment, respectively. This study confirmed that the ICT urinary antigen test remained to have a high sensitivity for diagnosis of pneumococcal infection after empiric antibiotic treatment was started. The ICT urinary antigen test would have a potential to guide the right choice of therapy for pneumonia in adults earlier. |
| doi_str_mv | 10.1007/s12013-014-0015-4 |
| format | Article |
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Streptococcus pneumoniae
. The Binax NOW
S. pneumoniae
immunochromatographic test (ICT) has become a more commonly used procedure to diagnose
S. pneumoniae
from community-acquired pneumonia in adults. However, performance of this test after empirical antimicrobial therapy is uncertain. Therefore, in this prospective study, we evaluate the impact of antimicrobial therapy on sensitivity of ICT test in 487 hospitalized adult patients. The results showed that 192 (39.4 %) and 295 (60.6 %) specimens were collected before (Group 1) or after antibiotic treatment (Group 2), respectively.
S. pneumoniae
was detected by ICT in 21 (10.9 %) patients in the Group 1 and 39 (13.2 %) in the Group 2 and their positive rates were not different (
P
> 0.05). However, The positive rate of blood and pleural fluid was declined from 5.7 to 2.7 % and sputum, from 9.9 to 4.7 % after the antibiotic treatment, respectively. This study confirmed that the ICT urinary antigen test remained to have a high sensitivity for diagnosis of pneumococcal infection after empiric antibiotic treatment was started. The ICT urinary antigen test would have a potential to guide the right choice of therapy for pneumonia in adults earlier.</description><identifier>ISSN: 1085-9195</identifier><identifier>EISSN: 1559-0283</identifier><identifier>DOI: 10.1007/s12013-014-0015-4</identifier><identifier>PMID: 24845151</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antigens, Bacterial - urine ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biotechnology ; Cell Biology ; Community-Acquired Infections - diagnosis ; Community-Acquired Infections - drug therapy ; Community-Acquired Infections - urine ; Female ; Humans ; Life Sciences ; Male ; Middle Aged ; Original Paper ; Pharmacology/Toxicology ; Pneumonia - diagnosis ; Pneumonia - drug therapy ; Pneumonia - urine ; Sensitivity and Specificity ; Streptococcus pneumoniae ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - immunology ; Streptococcus pneumoniae - physiology ; Young Adult</subject><ispartof>Cell biochemistry and biophysics, 2014-11, Vol.70 (2), p.1029-1034</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-c4962600e275790c30200a122832c694cc62e20ce951ce6ab314a9807fe16bec3</citedby><cites>FETCH-LOGICAL-c545t-c4962600e275790c30200a122832c694cc62e20ce951ce6ab314a9807fe16bec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12013-014-0015-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12013-014-0015-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41466,42535,51296</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24845151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Zhou, Ming</creatorcontrib><creatorcontrib>Xiao, Wei</creatorcontrib><creatorcontrib>Ai, Biao</creatorcontrib><creatorcontrib>Liu, Xuezheng</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><title>The Urinary Antigen Tests have High Sensitivity in Diagnosis of Pneumococcus Caused Community-Acquired Pneumonia Posterior to Antimicrobial Therapy</title><title>Cell biochemistry and biophysics</title><addtitle>Cell Biochem Biophys</addtitle><addtitle>Cell Biochem Biophys</addtitle><description>Antibiotic treatment before microbiological test significant reduces the positive rate of culture methods of
Streptococcus pneumoniae
. The Binax NOW
S. pneumoniae
immunochromatographic test (ICT) has become a more commonly used procedure to diagnose
S. pneumoniae
from community-acquired pneumonia in adults. However, performance of this test after empirical antimicrobial therapy is uncertain. Therefore, in this prospective study, we evaluate the impact of antimicrobial therapy on sensitivity of ICT test in 487 hospitalized adult patients. The results showed that 192 (39.4 %) and 295 (60.6 %) specimens were collected before (Group 1) or after antibiotic treatment (Group 2), respectively.
S. pneumoniae
was detected by ICT in 21 (10.9 %) patients in the Group 1 and 39 (13.2 %) in the Group 2 and their positive rates were not different (
P
> 0.05). However, The positive rate of blood and pleural fluid was declined from 5.7 to 2.7 % and sputum, from 9.9 to 4.7 % after the antibiotic treatment, respectively. This study confirmed that the ICT urinary antigen test remained to have a high sensitivity for diagnosis of pneumococcal infection after empiric antibiotic treatment was started. The ICT urinary antigen test would have a potential to guide the right choice of therapy for pneumonia in adults earlier.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antigens, Bacterial - urine</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Community-Acquired Infections - diagnosis</subject><subject>Community-Acquired Infections - drug therapy</subject><subject>Community-Acquired Infections - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Pneumonia - diagnosis</subject><subject>Pneumonia - drug therapy</subject><subject>Pneumonia - urine</subject><subject>Sensitivity and Specificity</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Streptococcus pneumoniae - physiology</subject><subject>Young Adult</subject><issn>1085-9195</issn><issn>1559-0283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkdFqFDEUhoNYbK0-gDcS8MabsedkkszM5bK1Vii00O11yKZnd1N2km0yU9jn8IXNdqqIIF4lJF_-k5-PsQ8IXxCgOcsoAOsKUFYAqCr5ip2gUl0Foq1flz20quqwU8fsbc4PAEKAlG_YsZCtVKjwhP1YbIjfJR9s2vNZGPyaAl9QHjLf2Cfil3694bcUsh_8kx_23Ad-7u06xOwzjyt-E2jso4vOjZnP7Zjpns9j34-h0NXMPY4-laMJC97ym5gHSj4mPsTnib13KS693fLyl2R3-3fsaGW3md6_rKfs7uLrYn5ZXV1_-z6fXVVOSTVUTnZaaAASjWo6cDUIAIuidBdOd9I5LUiAo06hI22XNUrbtdCsCPWSXH3KPk-5uxQfx9LZ9D472m5toDhmgxpb1KBU-39UtRo6XdeyoJ_-Qh_imEIpUiitm1q3oAqFE1W655xoZXbJ90WCQTAHuWaSa4pcc5BrDskfX5LHZU_3v1_8slkAMQG5XIU1pT9G_zP1Jwabr3k</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Chen, Ming</creator><creator>Zhou, Ming</creator><creator>Xiao, Wei</creator><creator>Ai, Biao</creator><creator>Liu, Xuezheng</creator><creator>Li, Yan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>The Urinary Antigen Tests have High Sensitivity in Diagnosis of Pneumococcus Caused Community-Acquired Pneumonia Posterior to Antimicrobial Therapy</title><author>Chen, Ming ; Zhou, Ming ; Xiao, Wei ; Ai, Biao ; Liu, Xuezheng ; Li, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-c4962600e275790c30200a122832c694cc62e20ce951ce6ab314a9807fe16bec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antigens, Bacterial - urine</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Cell Biology</topic><topic>Community-Acquired Infections - diagnosis</topic><topic>Community-Acquired Infections - drug therapy</topic><topic>Community-Acquired Infections - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Pneumonia - diagnosis</topic><topic>Pneumonia - drug therapy</topic><topic>Pneumonia - urine</topic><topic>Sensitivity and Specificity</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - drug effects</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Streptococcus pneumoniae - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Zhou, Ming</creatorcontrib><creatorcontrib>Xiao, Wei</creatorcontrib><creatorcontrib>Ai, Biao</creatorcontrib><creatorcontrib>Liu, Xuezheng</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ming</au><au>Zhou, Ming</au><au>Xiao, Wei</au><au>Ai, Biao</au><au>Liu, Xuezheng</au><au>Li, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Urinary Antigen Tests have High Sensitivity in Diagnosis of Pneumococcus Caused Community-Acquired Pneumonia Posterior to Antimicrobial Therapy</atitle><jtitle>Cell biochemistry and biophysics</jtitle><stitle>Cell Biochem Biophys</stitle><addtitle>Cell Biochem Biophys</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>70</volume><issue>2</issue><spage>1029</spage><epage>1034</epage><pages>1029-1034</pages><issn>1085-9195</issn><eissn>1559-0283</eissn><abstract>Antibiotic treatment before microbiological test significant reduces the positive rate of culture methods of
Streptococcus pneumoniae
. The Binax NOW
S. pneumoniae
immunochromatographic test (ICT) has become a more commonly used procedure to diagnose
S. pneumoniae
from community-acquired pneumonia in adults. However, performance of this test after empirical antimicrobial therapy is uncertain. Therefore, in this prospective study, we evaluate the impact of antimicrobial therapy on sensitivity of ICT test in 487 hospitalized adult patients. The results showed that 192 (39.4 %) and 295 (60.6 %) specimens were collected before (Group 1) or after antibiotic treatment (Group 2), respectively.
S. pneumoniae
was detected by ICT in 21 (10.9 %) patients in the Group 1 and 39 (13.2 %) in the Group 2 and their positive rates were not different (
P
> 0.05). However, The positive rate of blood and pleural fluid was declined from 5.7 to 2.7 % and sputum, from 9.9 to 4.7 % after the antibiotic treatment, respectively. This study confirmed that the ICT urinary antigen test remained to have a high sensitivity for diagnosis of pneumococcal infection after empiric antibiotic treatment was started. The ICT urinary antigen test would have a potential to guide the right choice of therapy for pneumonia in adults earlier.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24845151</pmid><doi>10.1007/s12013-014-0015-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antigens, Bacterial - urine Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Community-Acquired Infections - diagnosis Community-Acquired Infections - drug therapy Community-Acquired Infections - urine Female Humans Life Sciences Male Middle Aged Original Paper Pharmacology/Toxicology Pneumonia - diagnosis Pneumonia - drug therapy Pneumonia - urine Sensitivity and Specificity Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - immunology Streptococcus pneumoniae - physiology Young Adult |
| title | The Urinary Antigen Tests have High Sensitivity in Diagnosis of Pneumococcus Caused Community-Acquired Pneumonia Posterior to Antimicrobial Therapy |
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