An integrated molecular dynamics, principal component analysis and residue interaction network approach reveals the impact of M184V mutation on HIV reverse transcriptase resistance to lamivudine

The emergence of different drug resistant strains of HIV-1 reverse transcriptase (HIV RT) remains of prime interest in relation to viral pathogenesis as well as drug development. Amongst those mutations, M184V was found to cause a complete loss of ligand fitness. In this study, we report the first a...

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Veröffentlicht in:	Molecular bioSystems 2014-01, Vol.10 (8), p.2215-2228
Hauptverfasser:	Bhakat, Soumendranath, Martin, Alberto J M, Soliman, Mahmoud E S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Anti-HIV Agents - chemistry Computational Biology - methods Drug Resistance, Viral HIV Reverse Transcriptase - chemistry HIV Reverse Transcriptase - genetics Human immunodeficiency virus 1 Lamivudine - chemistry Methionine - metabolism Molecular Dynamics Simulation Mutation Principal Component Analysis Protein Structure, Secondary Quantitative Structure-Activity Relationship Valine - metabolism
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