Assessment of panobacumab as adjunctive immunotherapy for the treatment of nosocomial Pseudomonas aeruginosa pneumonia

The fully human anti-lipopolysaccharide (LPS) immunoglobulin M (IgM) monoclonal antibody panobacumab was developed as an adjunctive immunotherapy for the treatment of O11 serotype Pseudomonas aeruginosa infections. We evaluated the potential clinical efficacy of panobacumab in the treatment of nosoc...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 2014-10, Vol.33 (10), p.1861-1867
Hauptverfasser:	Que, Y.-A., Lazar, H., Wolff, M., François, B., Laterre, P.-F., Mercier, E., Garbino, J., Pagani, J.-L., Revelly, J.-P., Mus, E., Perez, A., Tamm, M., Rouby, J.-J., Lu, Q., Chastre, J., Eggimann, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Bacterial - administration & dosage Antibodies, Bacterial - adverse effects Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - pharmacokinetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cross Infection - microbiology Cross Infection - therapy Drug dosages Female General aspects Gram-negative bacteria Human infectious diseases. Experimental studies and models Humans Immunoglobulin M - administration & dosage Immunoglobulin M - adverse effects Immunologic Factors - administration & dosage Immunologic Factors - adverse effects Immunologic Factors - pharmacokinetics Immunotherapy Immunotherapy - methods Infectious diseases Internal Medicine Male Medical Microbiology Medical sciences Middle Aged Monoclonal antibodies Mortality Nosocomial infection Nosocomial infections Pharmacokinetics Physiology Pneumology Pneumonia Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - therapy Prospective Studies Pseudomonas aeruginosa Pseudomonas aeruginosa - classification Pseudomonas aeruginosa - immunology Respiratory system : syndromes and miscellaneous diseases Sepsis Serogroup Treatment Outcome Virulence
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