Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha- and beta-glucosidases suggesting anti-diabetic potential

PURPOSE: Inhibitors of intestinal alpha-glucosidases are used therapeutically to treat type 2 diabetes mellitus. Bacteria such as Actinoplanes sp. naturally produce potent alpha-glucosidase inhibitor compounds, including the most widely available drug acarbose. It is not known whether lactic acid ba...

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Veröffentlicht in:	European journal of nutrition 2014-10, Vol.53 (7), p.1465-1474
Hauptverfasser:	Panwar, Harsh, Calderwood, Danielle, Grant, Irene R, Grover, Sunita, Green, Brian D
Format:	Artikel
Sprache:	eng
Schlagworte:	acarbose Acarbose - metabolism Actinoplanes adverse effects alpha-glucosidase alpha-Glucosidases - metabolism Amylases - antagonists & inhibitors animal models Animals beta-galactosidase beta-glucosidase beta-Glucosidase - antagonists & inhibitors Bifidobacterium bifidum Biological and medical sciences blood glucose Blood Glucose - metabolism Chemistry Chemistry and Materials Science Diabetes Mellitus, Type 2 - therapy dietary supplements digestive system DNA, Bacterial - isolation & purification drugs Enzyme Inhibitors - pharmacology Escherichia coli feces Feces - microbiology Feeding. Feeding behavior functional foods Fundamental and applied biological sciences. Psychology glucose Glycoside Hydrolase Inhibitors - pharmacology Humans Hypoglycemic Agents - pharmacology Infant Intestines - enzymology Intestines - microbiology Lactase - antagonists & inhibitors lactic acid bacteria Lactobacillus Lactobacillus - classification Lactobacillus - isolation & purification Lactobacillus plantarum noninsulin-dependent diabetes mellitus Nutrition Original Contribution Probiotics Rats Rats, Sprague-Dawley Salmonella typhimurium sequence analysis Sequence Analysis, DNA starch Sucrase - antagonists & inhibitors sucrose alpha-glucosidase Vertebrates: anatomy and physiology, studies on body, several organs or systems
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