The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients
Purpose To identify the risk factors for incident enteric colonization by KPC-producing Klebsiella pneumoniae (KPC-Kp) resistant to colistin or tigecycline during Intensive Care Unit (ICU) stay. Method A prospective observational study of patients admitted to the ICU was conducted during a 27-month...
Gespeichert in:
| Veröffentlicht in: | Infection 2014-10, Vol.42 (5), p.883-890 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 890 |
|---|---|
| container_issue | 5 |
| container_start_page | 883 |
| container_title | Infection |
| container_volume | 42 |
| creator | Papadimitriou-Olivgeris, M. Christofidou, M. Fligou, F. Bartzavali, C. Vrettos, T. Filos, K. S. Marangos, M. Anastassiou, E. D. |
| description | Purpose
To identify the risk factors for incident enteric colonization by KPC-producing
Klebsiella pneumoniae
(KPC-Kp) resistant to colistin or tigecycline during Intensive Care Unit (ICU) stay.
Method
A prospective observational study of patients admitted to the ICU was conducted during a 27-month period. Rectal samples taken upon admission and weekly afterwards were inoculated on selective chromogenic agar.
K. pneumoniae
isolates were characterized by standard methodology. Mean inhibitory concentration (MIC) to colistin and tigecycline were determined by E-test. The presence of
bla
KPC
gene was confirmed by PCR.
Results
Among 254 patients, 62 (24.4 %) became colonized by colistin- resistant KPC-Kp during their stay. Multivariate analysis revealed that corticosteroid, colistin administration and number of colonized patients in nearby beds per day were significantly associated with colonization. Among 257 patients, 39 (17.9 %) became colonized by tigecycline resistant KPC-Kp during their stay. Risk factors identified by multivariate analysis were: days at risk, obesity, number of colonized patients treated in nearby beds per day and administration of tigecycline.
Conclusions
The high prevalence of colistin or tigecycline resistant KPC-Kp enteric carriage in ICU patients indicate that dissemination is due to their transfer from patient to patient via the personnel and indicates the importance of strict infection control protocols. |
| doi_str_mv | 10.1007/s15010-014-0653-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1618149665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1563988417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-b78a9be71ab009b6aa386997f293734051b3aea154be46defc0f9360a2367b263</originalsourceid><addsrcrecordid>eNqFkcFu1DAURS1ERYfCB7BBlth0Y_ocJ3a8RCNoUSvBoqwjx_MyuHLsYCdSh0_ha_E0BSEkxMqS73n3PvsS8orDWw6gLjJvgAMDXjOQjWD3T8iG10Iz0Eo8JRsQAKzllTwlz3O-A4BG1-oZOa0agJbrZkN-3H5FmqJHGgdqo4_BfTezi4FOCXNeElIX6FygncsZRxdWdaVdnosaE53dHu3BeheKG-Zyb8JMrz9v2ZTibrEu7Om1xz479N7QKeAylijz4G6Tm5013h-o855OJQHDnF-Qk8H4jC8fzzPy5cP72-0Vu_l0-XH77obZWrQz61VrdI-Kmx5A99IY0Uqt1VBpoUQNDe-FQcObusda7nCwMGghwVRCqr6S4oycr75l1W8L5rkbXbbHPQPGJXdc8pbXWpYf_i_aSKHbtuaqoG_-Qu_ikkJ5yJGqJKiqqQrFV8qmmHPCoZuSG006dBy6Y8fd2nFXOu6OHXf3Zeb1o_PSj7j7PfGr1AJUK5CLFPaY_oj-p-tP4Vm0bw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1562607252</pqid></control><display><type>article</type><title>The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Papadimitriou-Olivgeris, M. ; Christofidou, M. ; Fligou, F. ; Bartzavali, C. ; Vrettos, T. ; Filos, K. S. ; Marangos, M. ; Anastassiou, E. D.</creator><creatorcontrib>Papadimitriou-Olivgeris, M. ; Christofidou, M. ; Fligou, F. ; Bartzavali, C. ; Vrettos, T. ; Filos, K. S. ; Marangos, M. ; Anastassiou, E. D.</creatorcontrib><description>Purpose
To identify the risk factors for incident enteric colonization by KPC-producing
Klebsiella pneumoniae
(KPC-Kp) resistant to colistin or tigecycline during Intensive Care Unit (ICU) stay.
Method
A prospective observational study of patients admitted to the ICU was conducted during a 27-month period. Rectal samples taken upon admission and weekly afterwards were inoculated on selective chromogenic agar.
K. pneumoniae
isolates were characterized by standard methodology. Mean inhibitory concentration (MIC) to colistin and tigecycline were determined by E-test. The presence of
bla
KPC
gene was confirmed by PCR.
Results
Among 254 patients, 62 (24.4 %) became colonized by colistin- resistant KPC-Kp during their stay. Multivariate analysis revealed that corticosteroid, colistin administration and number of colonized patients in nearby beds per day were significantly associated with colonization. Among 257 patients, 39 (17.9 %) became colonized by tigecycline resistant KPC-Kp during their stay. Risk factors identified by multivariate analysis were: days at risk, obesity, number of colonized patients treated in nearby beds per day and administration of tigecycline.
Conclusions
The high prevalence of colistin or tigecycline resistant KPC-Kp enteric carriage in ICU patients indicate that dissemination is due to their transfer from patient to patient via the personnel and indicates the importance of strict infection control protocols.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-014-0653-x</identifier><identifier>PMID: 25008195</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; beta-Lactamases - genetics ; beta-Lactamases - metabolism ; Clinical and Epidemiological Study ; Colistin - pharmacology ; Colonization ; Drug Resistance, Bacterial ; Family Medicine ; Female ; General Practice ; Greece - epidemiology ; Hospitalization ; Hospitals, University ; Humans ; Infectious Diseases ; Intensive Care Units ; Internal Medicine ; Klebsiella Infections - epidemiology ; Klebsiella Infections - microbiology ; Klebsiella Infections - transmission ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - enzymology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Minocycline - analogs & derivatives ; Minocycline - pharmacology ; Multivariate analysis ; Observational studies ; Prospective Studies ; Risk Factors ; Tertiary Care Centers</subject><ispartof>Infection, 2014-10, Vol.42 (5), p.883-890</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b78a9be71ab009b6aa386997f293734051b3aea154be46defc0f9360a2367b263</citedby><cites>FETCH-LOGICAL-c438t-b78a9be71ab009b6aa386997f293734051b3aea154be46defc0f9360a2367b263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-014-0653-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-014-0653-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25008195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papadimitriou-Olivgeris, M.</creatorcontrib><creatorcontrib>Christofidou, M.</creatorcontrib><creatorcontrib>Fligou, F.</creatorcontrib><creatorcontrib>Bartzavali, C.</creatorcontrib><creatorcontrib>Vrettos, T.</creatorcontrib><creatorcontrib>Filos, K. S.</creatorcontrib><creatorcontrib>Marangos, M.</creatorcontrib><creatorcontrib>Anastassiou, E. D.</creatorcontrib><title>The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Purpose
To identify the risk factors for incident enteric colonization by KPC-producing
Klebsiella pneumoniae
(KPC-Kp) resistant to colistin or tigecycline during Intensive Care Unit (ICU) stay.
Method
A prospective observational study of patients admitted to the ICU was conducted during a 27-month period. Rectal samples taken upon admission and weekly afterwards were inoculated on selective chromogenic agar.
K. pneumoniae
isolates were characterized by standard methodology. Mean inhibitory concentration (MIC) to colistin and tigecycline were determined by E-test. The presence of
bla
KPC
gene was confirmed by PCR.
Results
Among 254 patients, 62 (24.4 %) became colonized by colistin- resistant KPC-Kp during their stay. Multivariate analysis revealed that corticosteroid, colistin administration and number of colonized patients in nearby beds per day were significantly associated with colonization. Among 257 patients, 39 (17.9 %) became colonized by tigecycline resistant KPC-Kp during their stay. Risk factors identified by multivariate analysis were: days at risk, obesity, number of colonized patients treated in nearby beds per day and administration of tigecycline.
Conclusions
The high prevalence of colistin or tigecycline resistant KPC-Kp enteric carriage in ICU patients indicate that dissemination is due to their transfer from patient to patient via the personnel and indicates the importance of strict infection control protocols.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - metabolism</subject><subject>Clinical and Epidemiological Study</subject><subject>Colistin - pharmacology</subject><subject>Colonization</subject><subject>Drug Resistance, Bacterial</subject><subject>Family Medicine</subject><subject>Female</subject><subject>General Practice</subject><subject>Greece - epidemiology</subject><subject>Hospitalization</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Intensive Care Units</subject><subject>Internal Medicine</subject><subject>Klebsiella Infections - epidemiology</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella Infections - transmission</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minocycline - analogs & derivatives</subject><subject>Minocycline - pharmacology</subject><subject>Multivariate analysis</subject><subject>Observational studies</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Tertiary Care Centers</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcFu1DAURS1ERYfCB7BBlth0Y_ocJ3a8RCNoUSvBoqwjx_MyuHLsYCdSh0_ha_E0BSEkxMqS73n3PvsS8orDWw6gLjJvgAMDXjOQjWD3T8iG10Iz0Eo8JRsQAKzllTwlz3O-A4BG1-oZOa0agJbrZkN-3H5FmqJHGgdqo4_BfTezi4FOCXNeElIX6FygncsZRxdWdaVdnosaE53dHu3BeheKG-Zyb8JMrz9v2ZTibrEu7Om1xz479N7QKeAylijz4G6Tm5013h-o855OJQHDnF-Qk8H4jC8fzzPy5cP72-0Vu_l0-XH77obZWrQz61VrdI-Kmx5A99IY0Uqt1VBpoUQNDe-FQcObusda7nCwMGghwVRCqr6S4oycr75l1W8L5rkbXbbHPQPGJXdc8pbXWpYf_i_aSKHbtuaqoG_-Qu_ikkJ5yJGqJKiqqQrFV8qmmHPCoZuSG006dBy6Y8fd2nFXOu6OHXf3Zeb1o_PSj7j7PfGr1AJUK5CLFPaY_oj-p-tP4Vm0bw</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Papadimitriou-Olivgeris, M.</creator><creator>Christofidou, M.</creator><creator>Fligou, F.</creator><creator>Bartzavali, C.</creator><creator>Vrettos, T.</creator><creator>Filos, K. S.</creator><creator>Marangos, M.</creator><creator>Anastassiou, E. D.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients</title><author>Papadimitriou-Olivgeris, M. ; Christofidou, M. ; Fligou, F. ; Bartzavali, C. ; Vrettos, T. ; Filos, K. S. ; Marangos, M. ; Anastassiou, E. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b78a9be71ab009b6aa386997f293734051b3aea154be46defc0f9360a2367b263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>beta-Lactamases - genetics</topic><topic>beta-Lactamases - metabolism</topic><topic>Clinical and Epidemiological Study</topic><topic>Colistin - pharmacology</topic><topic>Colonization</topic><topic>Drug Resistance, Bacterial</topic><topic>Family Medicine</topic><topic>Female</topic><topic>General Practice</topic><topic>Greece - epidemiology</topic><topic>Hospitalization</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Intensive Care Units</topic><topic>Internal Medicine</topic><topic>Klebsiella Infections - epidemiology</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella Infections - transmission</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - enzymology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minocycline - analogs & derivatives</topic><topic>Minocycline - pharmacology</topic><topic>Multivariate analysis</topic><topic>Observational studies</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Tertiary Care Centers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papadimitriou-Olivgeris, M.</creatorcontrib><creatorcontrib>Christofidou, M.</creatorcontrib><creatorcontrib>Fligou, F.</creatorcontrib><creatorcontrib>Bartzavali, C.</creatorcontrib><creatorcontrib>Vrettos, T.</creatorcontrib><creatorcontrib>Filos, K. S.</creatorcontrib><creatorcontrib>Marangos, M.</creatorcontrib><creatorcontrib>Anastassiou, E. D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papadimitriou-Olivgeris, M.</au><au>Christofidou, M.</au><au>Fligou, F.</au><au>Bartzavali, C.</au><au>Vrettos, T.</au><au>Filos, K. S.</au><au>Marangos, M.</au><au>Anastassiou, E. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients</atitle><jtitle>Infection</jtitle><stitle>Infection</stitle><addtitle>Infection</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>42</volume><issue>5</issue><spage>883</spage><epage>890</epage><pages>883-890</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>Purpose
To identify the risk factors for incident enteric colonization by KPC-producing
Klebsiella pneumoniae
(KPC-Kp) resistant to colistin or tigecycline during Intensive Care Unit (ICU) stay.
Method
A prospective observational study of patients admitted to the ICU was conducted during a 27-month period. Rectal samples taken upon admission and weekly afterwards were inoculated on selective chromogenic agar.
K. pneumoniae
isolates were characterized by standard methodology. Mean inhibitory concentration (MIC) to colistin and tigecycline were determined by E-test. The presence of
bla
KPC
gene was confirmed by PCR.
Results
Among 254 patients, 62 (24.4 %) became colonized by colistin- resistant KPC-Kp during their stay. Multivariate analysis revealed that corticosteroid, colistin administration and number of colonized patients in nearby beds per day were significantly associated with colonization. Among 257 patients, 39 (17.9 %) became colonized by tigecycline resistant KPC-Kp during their stay. Risk factors identified by multivariate analysis were: days at risk, obesity, number of colonized patients treated in nearby beds per day and administration of tigecycline.
Conclusions
The high prevalence of colistin or tigecycline resistant KPC-Kp enteric carriage in ICU patients indicate that dissemination is due to their transfer from patient to patient via the personnel and indicates the importance of strict infection control protocols.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25008195</pmid><doi>10.1007/s15010-014-0653-x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 2014-10, Vol.42 (5), p.883-890 |
| issn | 0300-8126 1439-0973 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1618149665 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adult Aged Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactamases - genetics beta-Lactamases - metabolism Clinical and Epidemiological Study Colistin - pharmacology Colonization Drug Resistance, Bacterial Family Medicine Female General Practice Greece - epidemiology Hospitalization Hospitals, University Humans Infectious Diseases Intensive Care Units Internal Medicine Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella Infections - transmission Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Male Medicine Medicine & Public Health Middle Aged Minocycline - analogs & derivatives Minocycline - pharmacology Multivariate analysis Observational studies Prospective Studies Risk Factors Tertiary Care Centers |
| title | The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T06%3A51%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20colonization%20pressure%20in%20the%20dissemination%20of%20colistin%20or%20tigecycline%20resistant%20KPC-producing%20Klebsiella%20pneumoniae%20in%20critically%20ill%20patients&rft.jtitle=Infection&rft.au=Papadimitriou-Olivgeris,%20M.&rft.date=2014-10-01&rft.volume=42&rft.issue=5&rft.spage=883&rft.epage=890&rft.pages=883-890&rft.issn=0300-8126&rft.eissn=1439-0973&rft_id=info:doi/10.1007/s15010-014-0653-x&rft_dat=%3Cproquest_cross%3E1563988417%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1562607252&rft_id=info:pmid/25008195&rfr_iscdi=true |