Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder
Objective Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in di...
Gespeichert in:
| Veröffentlicht in: | Bipolar disorders 2014-11, Vol.16 (7), p.769-772 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 772 |
|---|---|
| container_issue | 7 |
| container_start_page | 769 |
| container_title | Bipolar disorders |
| container_volume | 16 |
| creator | Galimberti, Daniela Prunas, Cecilia Paoli, Riccardo A Dell'Osso, Bernardo Fenoglio, Chiara Villa, Chiara Palazzo, Carlotta Cigliobianco, Michela Camuri, Giulia Serpente, Maria Scarpini, Elio Altamura, A Carlo |
| description | Objective
Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in different types of this disorder.
Methods
In this study, we performed an association analysis of GRN in an Italian population consisting of 134 patients with BD and 232 controls to evaluate progranulin plasma levels.
Results
The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD‐I) (odds ratio = 0.55, 95% confidence interval: 0.33–0.93; p = 0.024) but not bipolar II disorder (BD‐II) (p > 0.05). In addition, plasma progranulin levels are significantly decreased in BD [mean ± standard deviation (SD) 112 ± 35 versus 183 ± 93 ng/mL in controls; p |
| doi_str_mv | 10.1111/bdi.12180 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1618142787</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1618142787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4330-2fb13a7619ae12d7585d534296f29565c1e926e4cefaf5a8221ddbb4396ea3843</originalsourceid><addsrcrecordid>eNp1kE0zxEAQhqcUZVkO_oCaI1VC5iuZObJYyxYO2OPUJNNhyCZrJsH-e2FZJ33prnqffg8PQjskPiTdHGXWHRJKZLyCNghTKhIJkavft-xunvbQZgjPcUwSGot11KOcK8Wk2kD21teP3lRt6Sr8CBXgN-OdyVzpmjl2VVG2UOUQcPME2Lvwgova48zN6tJ4PMLWhdpb8Ac4axtc1c1f9hduobXClAG2f3Yf3Z-f3Q0uovHNcDQ4Hkc5ZyyOaJERZtKEKAOE2lRIYQXjVCUFVSIROQFFE-A5FKYQRlJKrM0yzlQChknO-mhv0Tvz9WsLodFTF3IoS1NB3QZNOi2E01SmHbq_QHNfh-Ch0DPvpsbPNYn1l1TdSdXfUjt296e2zaZgl-SvxQ44WgDvroT5_0365HT0WxktPlxo4GP5YfyLTlKWCj25Hurx1eVkMkilfmCfULGQBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1618142787</pqid></control><display><type>article</type><title>Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Galimberti, Daniela ; Prunas, Cecilia ; Paoli, Riccardo A ; Dell'Osso, Bernardo ; Fenoglio, Chiara ; Villa, Chiara ; Palazzo, Carlotta ; Cigliobianco, Michela ; Camuri, Giulia ; Serpente, Maria ; Scarpini, Elio ; Altamura, A Carlo</creator><creatorcontrib>Galimberti, Daniela ; Prunas, Cecilia ; Paoli, Riccardo A ; Dell'Osso, Bernardo ; Fenoglio, Chiara ; Villa, Chiara ; Palazzo, Carlotta ; Cigliobianco, Michela ; Camuri, Giulia ; Serpente, Maria ; Scarpini, Elio ; Altamura, A Carlo</creatorcontrib><description>Objective
Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in different types of this disorder.
Methods
In this study, we performed an association analysis of GRN in an Italian population consisting of 134 patients with BD and 232 controls to evaluate progranulin plasma levels.
Results
The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD‐I) (odds ratio = 0.55, 95% confidence interval: 0.33–0.93; p = 0.024) but not bipolar II disorder (BD‐II) (p > 0.05). In addition, plasma progranulin levels are significantly decreased in BD [mean ± standard deviation (SD) 112 ± 35 versus 183 ± 93 ng/mL in controls; p < 0.001].
Conclusions
Regarding the influence of GRN variability on BD susceptibility, the predisposing genetic background differs between BD‐I and BD‐II, possibly implying that pathogenic mechanisms differ between the two subtypes of BD.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1111/bdi.12180</identifier><identifier>PMID: 24499389</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Bipolar Disorder - blood ; Bipolar Disorder - classification ; Bipolar Disorder - genetics ; bipolar I disorder ; bipolar II disorder ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; genetics ; Genotype ; Humans ; Intercellular Signaling Peptides and Proteins - blood ; Intercellular Signaling Peptides and Proteins - genetics ; Italy ; Male ; Middle Aged ; Odds Ratio ; polymorphism ; Polymorphism, Single Nucleotide - genetics ; progranulin ; risk factor ; single nucleotide polymorphism ; Young Adult</subject><ispartof>Bipolar disorders, 2014-11, Vol.16 (7), p.769-772</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4330-2fb13a7619ae12d7585d534296f29565c1e926e4cefaf5a8221ddbb4396ea3843</citedby><cites>FETCH-LOGICAL-c4330-2fb13a7619ae12d7585d534296f29565c1e926e4cefaf5a8221ddbb4396ea3843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbdi.12180$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbdi.12180$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24499389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galimberti, Daniela</creatorcontrib><creatorcontrib>Prunas, Cecilia</creatorcontrib><creatorcontrib>Paoli, Riccardo A</creatorcontrib><creatorcontrib>Dell'Osso, Bernardo</creatorcontrib><creatorcontrib>Fenoglio, Chiara</creatorcontrib><creatorcontrib>Villa, Chiara</creatorcontrib><creatorcontrib>Palazzo, Carlotta</creatorcontrib><creatorcontrib>Cigliobianco, Michela</creatorcontrib><creatorcontrib>Camuri, Giulia</creatorcontrib><creatorcontrib>Serpente, Maria</creatorcontrib><creatorcontrib>Scarpini, Elio</creatorcontrib><creatorcontrib>Altamura, A Carlo</creatorcontrib><title>Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Objective
Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in different types of this disorder.
Methods
In this study, we performed an association analysis of GRN in an Italian population consisting of 134 patients with BD and 232 controls to evaluate progranulin plasma levels.
Results
The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD‐I) (odds ratio = 0.55, 95% confidence interval: 0.33–0.93; p = 0.024) but not bipolar II disorder (BD‐II) (p > 0.05). In addition, plasma progranulin levels are significantly decreased in BD [mean ± standard deviation (SD) 112 ± 35 versus 183 ± 93 ng/mL in controls; p < 0.001].
Conclusions
Regarding the influence of GRN variability on BD susceptibility, the predisposing genetic background differs between BD‐I and BD‐II, possibly implying that pathogenic mechanisms differ between the two subtypes of BD.</description><subject>Adult</subject><subject>Aged</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - classification</subject><subject>Bipolar Disorder - genetics</subject><subject>bipolar I disorder</subject><subject>bipolar II disorder</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Italy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>progranulin</subject><subject>risk factor</subject><subject>single nucleotide polymorphism</subject><subject>Young Adult</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE0zxEAQhqcUZVkO_oCaI1VC5iuZObJYyxYO2OPUJNNhyCZrJsH-e2FZJ33prnqffg8PQjskPiTdHGXWHRJKZLyCNghTKhIJkavft-xunvbQZgjPcUwSGot11KOcK8Wk2kD21teP3lRt6Sr8CBXgN-OdyVzpmjl2VVG2UOUQcPME2Lvwgova48zN6tJ4PMLWhdpb8Ac4axtc1c1f9hduobXClAG2f3Yf3Z-f3Q0uovHNcDQ4Hkc5ZyyOaJERZtKEKAOE2lRIYQXjVCUFVSIROQFFE-A5FKYQRlJKrM0yzlQChknO-mhv0Tvz9WsLodFTF3IoS1NB3QZNOi2E01SmHbq_QHNfh-Ch0DPvpsbPNYn1l1TdSdXfUjt296e2zaZgl-SvxQ44WgDvroT5_0365HT0WxktPlxo4GP5YfyLTlKWCj25Hurx1eVkMkilfmCfULGQBQ</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Galimberti, Daniela</creator><creator>Prunas, Cecilia</creator><creator>Paoli, Riccardo A</creator><creator>Dell'Osso, Bernardo</creator><creator>Fenoglio, Chiara</creator><creator>Villa, Chiara</creator><creator>Palazzo, Carlotta</creator><creator>Cigliobianco, Michela</creator><creator>Camuri, Giulia</creator><creator>Serpente, Maria</creator><creator>Scarpini, Elio</creator><creator>Altamura, A Carlo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder</title><author>Galimberti, Daniela ; Prunas, Cecilia ; Paoli, Riccardo A ; Dell'Osso, Bernardo ; Fenoglio, Chiara ; Villa, Chiara ; Palazzo, Carlotta ; Cigliobianco, Michela ; Camuri, Giulia ; Serpente, Maria ; Scarpini, Elio ; Altamura, A Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4330-2fb13a7619ae12d7585d534296f29565c1e926e4cefaf5a8221ddbb4396ea3843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - classification</topic><topic>Bipolar Disorder - genetics</topic><topic>bipolar I disorder</topic><topic>bipolar II disorder</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Italy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>progranulin</topic><topic>risk factor</topic><topic>single nucleotide polymorphism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galimberti, Daniela</creatorcontrib><creatorcontrib>Prunas, Cecilia</creatorcontrib><creatorcontrib>Paoli, Riccardo A</creatorcontrib><creatorcontrib>Dell'Osso, Bernardo</creatorcontrib><creatorcontrib>Fenoglio, Chiara</creatorcontrib><creatorcontrib>Villa, Chiara</creatorcontrib><creatorcontrib>Palazzo, Carlotta</creatorcontrib><creatorcontrib>Cigliobianco, Michela</creatorcontrib><creatorcontrib>Camuri, Giulia</creatorcontrib><creatorcontrib>Serpente, Maria</creatorcontrib><creatorcontrib>Scarpini, Elio</creatorcontrib><creatorcontrib>Altamura, A Carlo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galimberti, Daniela</au><au>Prunas, Cecilia</au><au>Paoli, Riccardo A</au><au>Dell'Osso, Bernardo</au><au>Fenoglio, Chiara</au><au>Villa, Chiara</au><au>Palazzo, Carlotta</au><au>Cigliobianco, Michela</au><au>Camuri, Giulia</au><au>Serpente, Maria</au><au>Scarpini, Elio</au><au>Altamura, A Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2014-11</date><risdate>2014</risdate><volume>16</volume><issue>7</issue><spage>769</spage><epage>772</epage><pages>769-772</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><abstract>Objective
Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in different types of this disorder.
Methods
In this study, we performed an association analysis of GRN in an Italian population consisting of 134 patients with BD and 232 controls to evaluate progranulin plasma levels.
Results
The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD‐I) (odds ratio = 0.55, 95% confidence interval: 0.33–0.93; p = 0.024) but not bipolar II disorder (BD‐II) (p > 0.05). In addition, plasma progranulin levels are significantly decreased in BD [mean ± standard deviation (SD) 112 ± 35 versus 183 ± 93 ng/mL in controls; p < 0.001].
Conclusions
Regarding the influence of GRN variability on BD susceptibility, the predisposing genetic background differs between BD‐I and BD‐II, possibly implying that pathogenic mechanisms differ between the two subtypes of BD.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24499389</pmid><doi>10.1111/bdi.12180</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1398-5647 |
| ispartof | Bipolar disorders, 2014-11, Vol.16 (7), p.769-772 |
| issn | 1398-5647 1399-5618 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1618142787 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Bipolar Disorder - blood Bipolar Disorder - classification Bipolar Disorder - genetics bipolar I disorder bipolar II disorder Case-Control Studies Female Genetic Predisposition to Disease genetics Genotype Humans Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - genetics Italy Male Middle Aged Odds Ratio polymorphism Polymorphism, Single Nucleotide - genetics progranulin risk factor single nucleotide polymorphism Young Adult |
| title | Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T23%3A09%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Progranulin%20gene%20variability%20influences%20the%20risk%20for%20bipolar%20I%20disorder,%20but%20not%20bipolar%20II%20disorder&rft.jtitle=Bipolar%20disorders&rft.au=Galimberti,%20Daniela&rft.date=2014-11&rft.volume=16&rft.issue=7&rft.spage=769&rft.epage=772&rft.pages=769-772&rft.issn=1398-5647&rft.eissn=1399-5618&rft_id=info:doi/10.1111/bdi.12180&rft_dat=%3Cproquest_cross%3E1618142787%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1618142787&rft_id=info:pmid/24499389&rfr_iscdi=true |