A proposed mechanism of action of a growth hormone-specific monoclonal antibody in the enhancement of hormonal activity

The potentiation of the biological activity of recombinant porcine growth hormone (pGH) by immunologic manipulation was investigated. An anti-pGH monoclonal antibody, designated PS-7.6, was generated and its effect on pGH was evaluated in hypophysectomized (hypox) rats. As expected, administration w...

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Veröffentlicht in:	Molecular immunology 1992-03, Vol.29 (3), p.313-317
Hauptverfasser:	Bosco Shang Wang, Lumanglas, Araceli L., Szewczyk, Eugene, McWilliams, William, Loullis, Costas C., Hart, Ian C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, immunoglobulins Antibodies, Monoclonal Biological and medical sciences Drug Synergism Female Fundamental and applied biological sciences. Psychology Fundamental immunology Growth - drug effects Growth Hormone - immunology Growth Hormone - pharmacokinetics Growth Hormone - pharmacology Hypophysectomy Molecular immunology Monoclonal antibodies Rats Rats, Inbred Strains Tissue Distribution Weight Gain - drug effects
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