Effects of 17-β estradiol and 4-nonylphenol on phase II electrophilic detoxification pathways in largemouth bass ( Micropterus salmoides) liver

The effects of in vivo exposure to a natural and synthetic estrogen upon three hepatic phase II enzyme pathways involved in cellular protection against reactive intermediates were investigated in the largemouth bass ( Micropterus salmoides). The pathways analyzed included glutathione S-transferases...

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Veröffentlicht in:	Comparative biochemistry and physiology. Toxicology & pharmacology 2004-03, Vol.137 (3), p.237-247
Hauptverfasser:	Hughes, Erin M, Gallagher, Evan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bass - metabolism Biotransformation Dicumarol - pharmacology Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Estradiol Estradiol - toxicity Freshwater Glutathione - biosynthesis Glutathione S-transferases Glutathione Transferase - biosynthesis Inactivation, Metabolic - physiology Largemouth bass Liver - metabolism Male Micropterus salmoides NAD(P)H Dehydrogenase (Quinone) - metabolism Nonylphenol Phenols - toxicity Quinone reductase Real-time PCR Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Subcellular Fractions Substrate Specificity Vitellogenins - metabolism
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