Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod
The distribution of vasopressin receptors was studied in the brain of a photoperiodic animal, the Siberian hamster. Attention was focused on [3H]vasopressin binding sites located in the hypothalamic ventromedial nucleus, medial tuberal nucleus, and ventral premammillary nucleus in males or females k...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1991-12, Vol.88 (24), p.11163-11167 |
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| creator | Dubois-Dauphin, M Theler, J M Zaganidis, N Dominik, W Tribollet, E Pévet, P Charpak, G Dreifuss, J J |
| description | The distribution of vasopressin receptors was studied in the brain of a photoperiodic animal, the Siberian hamster. Attention was focused on [3H]vasopressin binding sites located in the hypothalamic ventromedial nucleus, medial tuberal nucleus, and ventral premammillary nucleus in males or females kept in long or short photoperiod conditions. Displacement experiments with structural analogs suggested that vasopressin receptors in the hamster hypothalamus are of the vasopressor (V1) type. Quantitative data obtained with a gaseous detector of beta-particles indicated that in the ventromedial nucleus and in the ventral premammillary nucleus of animals in long photoperiod, the number of beta-particles emitted per unit area was significantly greater in males than in females. In the ventromedial hypothalamic nucleus, in both males and females, the number of beta-particles emitted was significantly lower in short than in long photoperiod conditions. In the ventral premammillary nucleus, shortening of the photoperiod had a significant effect in reducing the amount of [3H]vasopressin bound in females, but not in males. These data suggest that, in the hamster, the control of the expression of vasopressin receptors differs among various hypothalamic nuclei and may depend on the sex and/or on the level of circulating gonadal steroids. |
| doi_str_mv | 10.1073/pnas.88.24.11163 |
| format | Article |
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Attention was focused on [3H]vasopressin binding sites located in the hypothalamic ventromedial nucleus, medial tuberal nucleus, and ventral premammillary nucleus in males or females kept in long or short photoperiod conditions. Displacement experiments with structural analogs suggested that vasopressin receptors in the hamster hypothalamus are of the vasopressor (V1) type. Quantitative data obtained with a gaseous detector of beta-particles indicated that in the ventromedial nucleus and in the ventral premammillary nucleus of animals in long photoperiod, the number of beta-particles emitted per unit area was significantly greater in males than in females. In the ventromedial hypothalamic nucleus, in both males and females, the number of beta-particles emitted was significantly lower in short than in long photoperiod conditions. In the ventral premammillary nucleus, shortening of the photoperiod had a significant effect in reducing the amount of [3H]vasopressin bound in females, but not in males. These data suggest that, in the hamster, the control of the expression of vasopressin receptors differs among various hypothalamic nuclei and may depend on the sex and/or on the level of circulating gonadal steroids.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.88.24.11163</identifier><identifier>PMID: 1837144</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Acad Sciences</publisher><subject>Animals ; Autoradiography ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Cricetinae ; Darkness ; Female ; Fundamental and applied biological sciences. Psychology ; Hypothalamus - metabolism ; Hypothalamus - physiology ; Iodine Radioisotopes ; Light ; Male ; Molecular and cellular biology ; Phodopus sungorus ; Receptors, Angiotensin - metabolism ; Receptors, Vasopressin ; Sex Characteristics ; Tritium ; Vasopressins - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1991-12, Vol.88 (24), p.11163-11167</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-dc129645cd0188ba02105cd9316a2a4fec0b82c2e5061eb5d419ef1b29dee9d43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/88/24.cover.gif</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC53094/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC53094/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5225965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1837144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubois-Dauphin, M</creatorcontrib><creatorcontrib>Theler, J M</creatorcontrib><creatorcontrib>Zaganidis, N</creatorcontrib><creatorcontrib>Dominik, W</creatorcontrib><creatorcontrib>Tribollet, E</creatorcontrib><creatorcontrib>Pévet, P</creatorcontrib><creatorcontrib>Charpak, G</creatorcontrib><creatorcontrib>Dreifuss, J J</creatorcontrib><title>Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The distribution of vasopressin receptors was studied in the brain of a photoperiodic animal, the Siberian hamster. Attention was focused on [3H]vasopressin binding sites located in the hypothalamic ventromedial nucleus, medial tuberal nucleus, and ventral premammillary nucleus in males or females kept in long or short photoperiod conditions. Displacement experiments with structural analogs suggested that vasopressin receptors in the hamster hypothalamus are of the vasopressor (V1) type. Quantitative data obtained with a gaseous detector of beta-particles indicated that in the ventromedial nucleus and in the ventral premammillary nucleus of animals in long photoperiod, the number of beta-particles emitted per unit area was significantly greater in males than in females. In the ventromedial hypothalamic nucleus, in both males and females, the number of beta-particles emitted was significantly lower in short than in long photoperiod conditions. In the ventral premammillary nucleus, shortening of the photoperiod had a significant effect in reducing the amount of [3H]vasopressin bound in females, but not in males. These data suggest that, in the hamster, the control of the expression of vasopressin receptors differs among various hypothalamic nuclei and may depend on the sex and/or on the level of circulating gonadal steroids.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cricetinae</subject><subject>Darkness</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus - physiology</subject><subject>Iodine Radioisotopes</subject><subject>Light</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Phodopus sungorus</subject><subject>Receptors, Angiotensin - metabolism</subject><subject>Receptors, Vasopressin</subject><subject>Sex Characteristics</subject><subject>Tritium</subject><subject>Vasopressins - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EKtPCng0iC1SxyXDtOIktdYOq8pAqsYG15dg3JMiJjZ1UM_8eDzOUsoGVdX2-cx86hLygsKXQVm_DrNNWiC3jW0ppUz0iGwqSlg2X8JhsAFhbCs74U3Ke0ncAkLWAM3JGRdVSzjck3OxCxJRGPxe-L-508sd6LiIaDIuPqcjFoKe0YCyGffDLoJ2e1vyfioS7VTu3L-w4-RiG0RR6toXFgLPFeSnWkDuHwS8-YBy9fUae9NolfH56L8jX9zdfrj-Wt58_fLp-d1uaGpqltIYy2fDaWKBCdBoYhVzIijaaad6jgU4wwzDTFLvaciqxpx2TFlFaXl2Qq2PfsHYTWpN3idqpEMdJx73yelR_K_M4qG_-TtUVyIP98mSP_seKaVHTmAw6p2f0a1ItqyXwRv4XpA1tWlZBBuEImuhTitjf70JBHcJUhzCVEIpx9SvMbHn58IY_hmN6WX990nUy2vVRz2ZM91jN8pJNnbE3J-ww4Lf6YJDqV-cW3C0ZffVvtPoJA6rE0A</recordid><startdate>19911215</startdate><enddate>19911215</enddate><creator>Dubois-Dauphin, M</creator><creator>Theler, J M</creator><creator>Zaganidis, N</creator><creator>Dominik, W</creator><creator>Tribollet, E</creator><creator>Pévet, P</creator><creator>Charpak, G</creator><creator>Dreifuss, J J</creator><general>National Acad Sciences</general><general>National Academy of Sciences of the United States of America</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19911215</creationdate><title>Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod</title><author>Dubois-Dauphin, M ; Theler, J M ; Zaganidis, N ; Dominik, W ; Tribollet, E ; Pévet, P ; Charpak, G ; Dreifuss, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-dc129645cd0188ba02105cd9316a2a4fec0b82c2e5061eb5d419ef1b29dee9d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cricetinae</topic><topic>Darkness</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus - physiology</topic><topic>Iodine Radioisotopes</topic><topic>Light</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Phodopus sungorus</topic><topic>Receptors, Angiotensin - metabolism</topic><topic>Receptors, Vasopressin</topic><topic>Sex Characteristics</topic><topic>Tritium</topic><topic>Vasopressins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubois-Dauphin, M</creatorcontrib><creatorcontrib>Theler, J M</creatorcontrib><creatorcontrib>Zaganidis, N</creatorcontrib><creatorcontrib>Dominik, W</creatorcontrib><creatorcontrib>Tribollet, E</creatorcontrib><creatorcontrib>Pévet, P</creatorcontrib><creatorcontrib>Charpak, G</creatorcontrib><creatorcontrib>Dreifuss, J J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubois-Dauphin, M</au><au>Theler, J M</au><au>Zaganidis, N</au><au>Dominik, W</au><au>Tribollet, E</au><au>Pévet, P</au><au>Charpak, G</au><au>Dreifuss, J J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1991-12-15</date><risdate>1991</risdate><volume>88</volume><issue>24</issue><spage>11163</spage><epage>11167</epage><pages>11163-11167</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The distribution of vasopressin receptors was studied in the brain of a photoperiodic animal, the Siberian hamster. Attention was focused on [3H]vasopressin binding sites located in the hypothalamic ventromedial nucleus, medial tuberal nucleus, and ventral premammillary nucleus in males or females kept in long or short photoperiod conditions. Displacement experiments with structural analogs suggested that vasopressin receptors in the hamster hypothalamus are of the vasopressor (V1) type. Quantitative data obtained with a gaseous detector of beta-particles indicated that in the ventromedial nucleus and in the ventral premammillary nucleus of animals in long photoperiod, the number of beta-particles emitted per unit area was significantly greater in males than in females. In the ventromedial hypothalamic nucleus, in both males and females, the number of beta-particles emitted was significantly lower in short than in long photoperiod conditions. In the ventral premammillary nucleus, shortening of the photoperiod had a significant effect in reducing the amount of [3H]vasopressin bound in females, but not in males. These data suggest that, in the hamster, the control of the expression of vasopressin receptors differs among various hypothalamic nuclei and may depend on the sex and/or on the level of circulating gonadal steroids.</abstract><cop>Washington, DC</cop><pub>National Acad Sciences</pub><pmid>1837144</pmid><doi>10.1073/pnas.88.24.11163</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autoradiography Biological and medical sciences Cell receptors Cell structures and functions Cricetinae Darkness Female Fundamental and applied biological sciences. Psychology Hypothalamus - metabolism Hypothalamus - physiology Iodine Radioisotopes Light Male Molecular and cellular biology Phodopus sungorus Receptors, Angiotensin - metabolism Receptors, Vasopressin Sex Characteristics Tritium Vasopressins - metabolism |
| title | Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod |
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