Airway epithelial cell-derived insulin-like growth factor-1 triggers skewed CD8+ T cell polarization

Skewed CD8+ T cell responses are important in airway inflammation. This study investigates the role of the airway epithelial cell‐derived insulin‐like growth factor 1 (IGF1) in contributing to CD8+ T cell polarization. Expression of IGF1 in the airway epithelial cell line, RPMI2650 cells, was assess...

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Veröffentlicht in:	Cell biology international 2014-10, Vol.38 (10), p.1148-1154
Hauptverfasser:	Zou, Jian-Yong, Huang, Shao-hong, Li, Yun, Chen, Hui-guo, Rong, Jian, Ye, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	airway Antigens, Dermatophagoides - pharmacology Arthropod Proteins - pharmacology CD8 T cells CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Line Cell Proliferation - drug effects Cell Shape - drug effects Cysteine Endopeptidases - pharmacology DNA Methylation - drug effects epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Humans Insulin-Like Growth Factor I - isolation & purification Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology insulin-like growth factor-1 MAP Kinase Kinase Kinases - metabolism P53 gene methylation Signal Transduction - drug effects Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Up-Regulation - drug effects
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