Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis
Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the m...
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| Veröffentlicht in: | Acta dermato-venereologica 2014-01, Vol.94 (6), p.691-694 |
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| container_title | Acta dermato-venereologica |
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| creator | Jensen, Peter Zachariae, Claus Christensen, Robin Geiker, Nina R W Schaadt, Bente K Stender, Steen Astrup, Arne Hansen, Peter R Skov, Lone |
| description | Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction. |
| doi_str_mv | 10.2340/00015555-1824 |
| format | Article |
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We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.2340/00015555-1824</identifier><identifier>PMID: 24556829</identifier><language>eng</language><publisher>Sweden</publisher><subject>Biomarkers - blood ; Blood Glucose - metabolism ; Blood Pressure ; Caloric Restriction ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - prevention & control ; Comorbidity ; Denmark - epidemiology ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - physiopathology ; Glycated Hemoglobin A - metabolism ; Heart Rate ; Humans ; Lipids - blood ; Manometry ; Microvessels - metabolism ; Microvessels - physiopathology ; Obesity - blood ; Obesity - diagnosis ; Obesity - diet therapy ; Obesity - epidemiology ; Obesity - physiopathology ; Plasminogen Activator Inhibitor 1 - blood ; Protective Factors ; Psoriasis - diagnosis ; Psoriasis - epidemiology ; Risk Factors ; Time Factors ; Treatment Outcome ; Weight Loss</subject><ispartof>Acta dermato-venereologica, 2014-01, Vol.94 (6), p.691-694</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-f2b41d1cede8f2f84b0fb9edd652d29d1dd72d6fff3f48dd8d43a46464519f7a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24556829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Peter</creatorcontrib><creatorcontrib>Zachariae, Claus</creatorcontrib><creatorcontrib>Christensen, Robin</creatorcontrib><creatorcontrib>Geiker, Nina R W</creatorcontrib><creatorcontrib>Schaadt, Bente K</creatorcontrib><creatorcontrib>Stender, Steen</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Hansen, Peter R</creatorcontrib><creatorcontrib>Skov, Lone</creatorcontrib><title>Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.</description><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Caloric Restriction</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Comorbidity</subject><subject>Denmark - epidemiology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Manometry</subject><subject>Microvessels - metabolism</subject><subject>Microvessels - physiopathology</subject><subject>Obesity - blood</subject><subject>Obesity - diagnosis</subject><subject>Obesity - diet therapy</subject><subject>Obesity - epidemiology</subject><subject>Obesity - physiopathology</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Protective Factors</subject><subject>Psoriasis - diagnosis</subject><subject>Psoriasis - epidemiology</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEYmNw5Ipy5FJI0qRNj2gaH9IkLnDgVKWNzQLdMpKUiX9Pqw3sg2X58Sv7JeSSsxuRS3bLGONqiIxrIY_IlBeKZ4Kp8phMx1k2DifkLMaPoRWK61MyEVKpQotqSt4WiNAm6pHuwL2vEu18jNRvaFoBbU2wzn-b2PadCTS4-Em3waPrYNzwDUSgW5McbFKkO5dWdBt9cCa6eE5O0HQRLg51Rl7vFy_zx2z5_PA0v1tmbZ6LlKFoJLe8BQsaBWrZMGwqsLZQworKcmtLYQtEzFFqa7WVuZHFkIpXWJp8Rq73usNhXz3EVK9dbKHrzAZ8H2te8EKWWnI1oNkebcPwZACst8GtTfipOatHN-s_N-vRzYG_Okj3zRrsP_1nX_4LW9Bwhg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Jensen, Peter</creator><creator>Zachariae, Claus</creator><creator>Christensen, Robin</creator><creator>Geiker, Nina R W</creator><creator>Schaadt, Bente K</creator><creator>Stender, Steen</creator><creator>Astrup, Arne</creator><creator>Hansen, Peter R</creator><creator>Skov, Lone</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis</title><author>Jensen, Peter ; Zachariae, Claus ; Christensen, Robin ; Geiker, Nina R W ; Schaadt, Bente K ; Stender, Steen ; Astrup, Arne ; Hansen, Peter R ; Skov, Lone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-f2b41d1cede8f2f84b0fb9edd652d29d1dd72d6fff3f48dd8d43a46464519f7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Caloric Restriction</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Comorbidity</topic><topic>Denmark - epidemiology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Manometry</topic><topic>Microvessels - metabolism</topic><topic>Microvessels - physiopathology</topic><topic>Obesity - blood</topic><topic>Obesity - diagnosis</topic><topic>Obesity - diet therapy</topic><topic>Obesity - epidemiology</topic><topic>Obesity - physiopathology</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Protective Factors</topic><topic>Psoriasis - diagnosis</topic><topic>Psoriasis - epidemiology</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Peter</creatorcontrib><creatorcontrib>Zachariae, Claus</creatorcontrib><creatorcontrib>Christensen, Robin</creatorcontrib><creatorcontrib>Geiker, Nina R W</creatorcontrib><creatorcontrib>Schaadt, Bente K</creatorcontrib><creatorcontrib>Stender, Steen</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Hansen, Peter R</creatorcontrib><creatorcontrib>Skov, Lone</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Peter</au><au>Zachariae, Claus</au><au>Christensen, Robin</au><au>Geiker, Nina R W</au><au>Schaadt, Bente K</au><au>Stender, Steen</au><au>Astrup, Arne</au><au>Hansen, Peter R</au><au>Skov, Lone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>94</volume><issue>6</issue><spage>691</spage><epage>694</epage><pages>691-694</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><abstract>Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.</abstract><cop>Sweden</cop><pmid>24556829</pmid><doi>10.2340/00015555-1824</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biomarkers - blood Blood Glucose - metabolism Blood Pressure Caloric Restriction Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Cardiovascular Diseases - prevention & control Comorbidity Denmark - epidemiology Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Glycated Hemoglobin A - metabolism Heart Rate Humans Lipids - blood Manometry Microvessels - metabolism Microvessels - physiopathology Obesity - blood Obesity - diagnosis Obesity - diet therapy Obesity - epidemiology Obesity - physiopathology Plasminogen Activator Inhibitor 1 - blood Protective Factors Psoriasis - diagnosis Psoriasis - epidemiology Risk Factors Time Factors Treatment Outcome Weight Loss |
| title | Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis |
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