Discovery of Potent and Selective Sirtuin 2 (SIRT2) Inhibitors Using a Fragment-Based Approach

Sirtuin 2 (SIRT2) is one of the sirtuins, a family of NAD+-dependent deacetylases that act on a variety of histone and non-histone substrates. Accumulating biological functions and potential therapeutic applications have drawn interest in the discovery and development of SIRT2 inhibitors. Herein we...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-10, Vol.57 (20), p.8340-8357
Hauptverfasser:	Cui, Huaqing, Kamal, Zeeshan, Ai, Teng, Xu, Yanli, More, Swati S, Wilson, Daniel J, Chen, Liqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dogs Drug Design Drug Discovery Drug Evaluation, Preclinical - methods Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Ligands Madin Darby Canine Kidney Cells MCF-7 Cells - drug effects Molecular Structure Niacinamide - chemistry Sirtuin 2 - antagonists & inhibitors Structure-Activity Relationship Sulfonic Acids - chemistry Suramin - chemistry Suramin - pharmacology
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