Analysis of Viral Testing in Nonacetaminophen Pediatric Acute Liver Failure
ABSTRACT Objective: Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large‐scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants. Methods: Participants were enrolled in the PALF registry....
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2014-11, Vol.59 (5), p.616-623 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 623 |
|---|---|
| container_issue | 5 |
| container_start_page | 616 |
| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 59 |
| creator | Schwarz, Kathleen B. Olio, Dominic Dell Lobritto, Steven J. Lopez, M. James Rodriguez‐Baez, Norberto Yazigi, Nada A. Belle, Steven H. Zhang, Song Squires, Robert H. |
| description | ABSTRACT
Objective:
Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large‐scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.
Methods:
Participants were enrolled in the PALF registry. Diagnostic evaluation and final diagnosis were determined by the site investigator and methods for viral testing by local standard of care. Viruses were classified as either causative viruses (CVs) or associated viruses (AVs). Supplemental testing for CV was performed if not done clinically and serum was available. Final diagnoses included “viral,” “indeterminate,” and “other.”
Results:
Of 860 participants, 820 had at least 1 test result for a CV or AV. A positive viral test was found in 166/820 (20.2%) participants and distributed among “viral” (66/80 [82.5%]), “indeterminate” (52/420 [12.4%]), and “other” (48/320 [15.0%]) diagnoses. CVs accounted for 81/166 (48.8%) positive tests. Herpes simplex virus (HSV) was positive in 39/335 (11.6%) who were tested 26/103 (25.2%) and 13/232 (5.6%) among infants 0 to 6 and >6 months, respectively. HSV was not tested in 61.0% and 53% of the overall cohort and those 0 to 6 months, respectively. Supplemental testing yielded 17 positive, including 5 HSV.
Conclusions:
Viral testing in PALF occurs frequently but is often incomplete. The evidence for acute viral infection was found in 20.2% of those tested for viruses. HSV is an important viral cause for PALF in all age groups. The etiopathogenic role of CV and AV in PALF requires further investigation. |
| doi_str_mv | 10.1097/MPG.0000000000000512 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1616477439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1616477439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5186-ce0c3ee093018cf444c2144211778f83fe656a6bb5c83f7d6d4f67f759da5be33</originalsourceid><addsrcrecordid>eNqNUE1vEzEUtBAVDS3_ACEfuWzxW3_tHjiEihTaUHJoe7Uc71ticHZTe5cq_76ukpaKU5_09DTSzLzREPIe2AmwWn_6sTg7Yc9HQvmKTEByVYiKwWsyYaXWRQmgDsnblH5njhaSvSGHpeQie4gJuZh2NmyTT7Rv6Y2PNtArTIPvflHf0cu-sw4Hu_Zdv1lhRxfYeDtE7-jUjQPSuf-Lkc6sD2PEY3LQ2pDw3f4ekevZ16vTb8X859n30-m8cBIqVThkjiOymjOoXCuEcCUIkXNqXbUVb1FJZdVyKV0GulGNaJVutawbK5fI-RH5uPPdxP52zGnN2ieHIdgO-zEZUKCE1oLXmSp2VBf7lCK2ZhP92satAWYeajS5RvN_jVn2Yf9hXK6xeRI99vbP964PA8b0J4x3GM0KbRhWZmejVVEyEAAZFXlBZdnnvcwH3L4oizlfXPIvM6aZrPk9muSNRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1616477439</pqid></control><display><type>article</type><title>Analysis of Viral Testing in Nonacetaminophen Pediatric Acute Liver Failure</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Schwarz, Kathleen B. ; Olio, Dominic Dell ; Lobritto, Steven J. ; Lopez, M. James ; Rodriguez‐Baez, Norberto ; Yazigi, Nada A. ; Belle, Steven H. ; Zhang, Song ; Squires, Robert H.</creator><creatorcontrib>Schwarz, Kathleen B. ; Olio, Dominic Dell ; Lobritto, Steven J. ; Lopez, M. James ; Rodriguez‐Baez, Norberto ; Yazigi, Nada A. ; Belle, Steven H. ; Zhang, Song ; Squires, Robert H. ; Pediatric Acute Liver Failure Study Group</creatorcontrib><description>ABSTRACT
Objective:
Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large‐scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.
Methods:
Participants were enrolled in the PALF registry. Diagnostic evaluation and final diagnosis were determined by the site investigator and methods for viral testing by local standard of care. Viruses were classified as either causative viruses (CVs) or associated viruses (AVs). Supplemental testing for CV was performed if not done clinically and serum was available. Final diagnoses included “viral,” “indeterminate,” and “other.”
Results:
Of 860 participants, 820 had at least 1 test result for a CV or AV. A positive viral test was found in 166/820 (20.2%) participants and distributed among “viral” (66/80 [82.5%]), “indeterminate” (52/420 [12.4%]), and “other” (48/320 [15.0%]) diagnoses. CVs accounted for 81/166 (48.8%) positive tests. Herpes simplex virus (HSV) was positive in 39/335 (11.6%) who were tested 26/103 (25.2%) and 13/232 (5.6%) among infants 0 to 6 and >6 months, respectively. HSV was not tested in 61.0% and 53% of the overall cohort and those 0 to 6 months, respectively. Supplemental testing yielded 17 positive, including 5 HSV.
Conclusions:
Viral testing in PALF occurs frequently but is often incomplete. The evidence for acute viral infection was found in 20.2% of those tested for viruses. HSV is an important viral cause for PALF in all age groups. The etiopathogenic role of CV and AV in PALF requires further investigation.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0000000000000512</identifier><identifier>PMID: 25340974</identifier><language>eng</language><publisher>United States: by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</publisher><subject>Adolescent ; Antibodies, Viral - blood ; Child ; Child, Preschool ; cytomegalovirus ; Epstein‐Barr virus ; hepatotropic viruses ; Herpes Simplex - complications ; Herpes Simplex - diagnosis ; Herpes Simplex - virology ; herpesvirus ; human herpesvirus‐6 ; Humans ; Infant ; Infant, Newborn ; Liver Failure, Acute - diagnosis ; Liver Failure, Acute - etiology ; Liver Failure, Acute - virology ; Polymerase Chain Reaction ; Simplexvirus - genetics ; Simplexvirus - immunology</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2014-11, Vol.59 (5), p.616-623</ispartof><rights>2014 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5186-ce0c3ee093018cf444c2144211778f83fe656a6bb5c83f7d6d4f67f759da5be33</citedby><cites>FETCH-LOGICAL-c5186-ce0c3ee093018cf444c2144211778f83fe656a6bb5c83f7d6d4f67f759da5be33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0000000000000512$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0000000000000512$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25340974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, Kathleen B.</creatorcontrib><creatorcontrib>Olio, Dominic Dell</creatorcontrib><creatorcontrib>Lobritto, Steven J.</creatorcontrib><creatorcontrib>Lopez, M. James</creatorcontrib><creatorcontrib>Rodriguez‐Baez, Norberto</creatorcontrib><creatorcontrib>Yazigi, Nada A.</creatorcontrib><creatorcontrib>Belle, Steven H.</creatorcontrib><creatorcontrib>Zhang, Song</creatorcontrib><creatorcontrib>Squires, Robert H.</creatorcontrib><creatorcontrib>Pediatric Acute Liver Failure Study Group</creatorcontrib><title>Analysis of Viral Testing in Nonacetaminophen Pediatric Acute Liver Failure</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objective:
Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large‐scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.
Methods:
Participants were enrolled in the PALF registry. Diagnostic evaluation and final diagnosis were determined by the site investigator and methods for viral testing by local standard of care. Viruses were classified as either causative viruses (CVs) or associated viruses (AVs). Supplemental testing for CV was performed if not done clinically and serum was available. Final diagnoses included “viral,” “indeterminate,” and “other.”
Results:
Of 860 participants, 820 had at least 1 test result for a CV or AV. A positive viral test was found in 166/820 (20.2%) participants and distributed among “viral” (66/80 [82.5%]), “indeterminate” (52/420 [12.4%]), and “other” (48/320 [15.0%]) diagnoses. CVs accounted for 81/166 (48.8%) positive tests. Herpes simplex virus (HSV) was positive in 39/335 (11.6%) who were tested 26/103 (25.2%) and 13/232 (5.6%) among infants 0 to 6 and >6 months, respectively. HSV was not tested in 61.0% and 53% of the overall cohort and those 0 to 6 months, respectively. Supplemental testing yielded 17 positive, including 5 HSV.
Conclusions:
Viral testing in PALF occurs frequently but is often incomplete. The evidence for acute viral infection was found in 20.2% of those tested for viruses. HSV is an important viral cause for PALF in all age groups. The etiopathogenic role of CV and AV in PALF requires further investigation.</description><subject>Adolescent</subject><subject>Antibodies, Viral - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>cytomegalovirus</subject><subject>Epstein‐Barr virus</subject><subject>hepatotropic viruses</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - diagnosis</subject><subject>Herpes Simplex - virology</subject><subject>herpesvirus</subject><subject>human herpesvirus‐6</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Liver Failure, Acute - diagnosis</subject><subject>Liver Failure, Acute - etiology</subject><subject>Liver Failure, Acute - virology</subject><subject>Polymerase Chain Reaction</subject><subject>Simplexvirus - genetics</subject><subject>Simplexvirus - immunology</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUE1vEzEUtBAVDS3_ACEfuWzxW3_tHjiEihTaUHJoe7Uc71ticHZTe5cq_76ukpaKU5_09DTSzLzREPIe2AmwWn_6sTg7Yc9HQvmKTEByVYiKwWsyYaXWRQmgDsnblH5njhaSvSGHpeQie4gJuZh2NmyTT7Rv6Y2PNtArTIPvflHf0cu-sw4Hu_Zdv1lhRxfYeDtE7-jUjQPSuf-Lkc6sD2PEY3LQ2pDw3f4ekevZ16vTb8X859n30-m8cBIqVThkjiOymjOoXCuEcCUIkXNqXbUVb1FJZdVyKV0GulGNaJVutawbK5fI-RH5uPPdxP52zGnN2ieHIdgO-zEZUKCE1oLXmSp2VBf7lCK2ZhP92satAWYeajS5RvN_jVn2Yf9hXK6xeRI99vbP964PA8b0J4x3GM0KbRhWZmejVVEyEAAZFXlBZdnnvcwH3L4oizlfXPIvM6aZrPk9muSNRQ</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Schwarz, Kathleen B.</creator><creator>Olio, Dominic Dell</creator><creator>Lobritto, Steven J.</creator><creator>Lopez, M. James</creator><creator>Rodriguez‐Baez, Norberto</creator><creator>Yazigi, Nada A.</creator><creator>Belle, Steven H.</creator><creator>Zhang, Song</creator><creator>Squires, Robert H.</creator><general>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Analysis of Viral Testing in Nonacetaminophen Pediatric Acute Liver Failure</title><author>Schwarz, Kathleen B. ; Olio, Dominic Dell ; Lobritto, Steven J. ; Lopez, M. James ; Rodriguez‐Baez, Norberto ; Yazigi, Nada A. ; Belle, Steven H. ; Zhang, Song ; Squires, Robert H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5186-ce0c3ee093018cf444c2144211778f83fe656a6bb5c83f7d6d4f67f759da5be33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Antibodies, Viral - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>cytomegalovirus</topic><topic>Epstein‐Barr virus</topic><topic>hepatotropic viruses</topic><topic>Herpes Simplex - complications</topic><topic>Herpes Simplex - diagnosis</topic><topic>Herpes Simplex - virology</topic><topic>herpesvirus</topic><topic>human herpesvirus‐6</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Liver Failure, Acute - diagnosis</topic><topic>Liver Failure, Acute - etiology</topic><topic>Liver Failure, Acute - virology</topic><topic>Polymerase Chain Reaction</topic><topic>Simplexvirus - genetics</topic><topic>Simplexvirus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwarz, Kathleen B.</creatorcontrib><creatorcontrib>Olio, Dominic Dell</creatorcontrib><creatorcontrib>Lobritto, Steven J.</creatorcontrib><creatorcontrib>Lopez, M. James</creatorcontrib><creatorcontrib>Rodriguez‐Baez, Norberto</creatorcontrib><creatorcontrib>Yazigi, Nada A.</creatorcontrib><creatorcontrib>Belle, Steven H.</creatorcontrib><creatorcontrib>Zhang, Song</creatorcontrib><creatorcontrib>Squires, Robert H.</creatorcontrib><creatorcontrib>Pediatric Acute Liver Failure Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwarz, Kathleen B.</au><au>Olio, Dominic Dell</au><au>Lobritto, Steven J.</au><au>Lopez, M. James</au><au>Rodriguez‐Baez, Norberto</au><au>Yazigi, Nada A.</au><au>Belle, Steven H.</au><au>Zhang, Song</au><au>Squires, Robert H.</au><aucorp>Pediatric Acute Liver Failure Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Viral Testing in Nonacetaminophen Pediatric Acute Liver Failure</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2014-11</date><risdate>2014</risdate><volume>59</volume><issue>5</issue><spage>616</spage><epage>623</epage><pages>616-623</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><abstract>ABSTRACT
Objective:
Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large‐scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.
Methods:
Participants were enrolled in the PALF registry. Diagnostic evaluation and final diagnosis were determined by the site investigator and methods for viral testing by local standard of care. Viruses were classified as either causative viruses (CVs) or associated viruses (AVs). Supplemental testing for CV was performed if not done clinically and serum was available. Final diagnoses included “viral,” “indeterminate,” and “other.”
Results:
Of 860 participants, 820 had at least 1 test result for a CV or AV. A positive viral test was found in 166/820 (20.2%) participants and distributed among “viral” (66/80 [82.5%]), “indeterminate” (52/420 [12.4%]), and “other” (48/320 [15.0%]) diagnoses. CVs accounted for 81/166 (48.8%) positive tests. Herpes simplex virus (HSV) was positive in 39/335 (11.6%) who were tested 26/103 (25.2%) and 13/232 (5.6%) among infants 0 to 6 and >6 months, respectively. HSV was not tested in 61.0% and 53% of the overall cohort and those 0 to 6 months, respectively. Supplemental testing yielded 17 positive, including 5 HSV.
Conclusions:
Viral testing in PALF occurs frequently but is often incomplete. The evidence for acute viral infection was found in 20.2% of those tested for viruses. HSV is an important viral cause for PALF in all age groups. The etiopathogenic role of CV and AV in PALF requires further investigation.</abstract><cop>United States</cop><pub>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</pub><pmid>25340974</pmid><doi>10.1097/MPG.0000000000000512</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 2014-11, Vol.59 (5), p.616-623 |
| issn | 0277-2116 1536-4801 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1616477439 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Adolescent Antibodies, Viral - blood Child Child, Preschool cytomegalovirus Epstein‐Barr virus hepatotropic viruses Herpes Simplex - complications Herpes Simplex - diagnosis Herpes Simplex - virology herpesvirus human herpesvirus‐6 Humans Infant Infant, Newborn Liver Failure, Acute - diagnosis Liver Failure, Acute - etiology Liver Failure, Acute - virology Polymerase Chain Reaction Simplexvirus - genetics Simplexvirus - immunology |
| title | Analysis of Viral Testing in Nonacetaminophen Pediatric Acute Liver Failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T06%3A11%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20Viral%20Testing%20in%20Nonacetaminophen%20Pediatric%20Acute%20Liver%20Failure&rft.jtitle=Journal%20of%20pediatric%20gastroenterology%20and%20nutrition&rft.au=Schwarz,%20Kathleen%20B.&rft.aucorp=Pediatric%20Acute%20Liver%20Failure%20Study%20Group&rft.date=2014-11&rft.volume=59&rft.issue=5&rft.spage=616&rft.epage=623&rft.pages=616-623&rft.issn=0277-2116&rft.eissn=1536-4801&rft_id=info:doi/10.1097/MPG.0000000000000512&rft_dat=%3Cproquest_cross%3E1616477439%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1616477439&rft_id=info:pmid/25340974&rfr_iscdi=true |