Diffusion-weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm
Background The aim of this study was to evaluate the usefulness of high b‐value diffusion‐weighted magnetic resonance imaging (DWI) for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN). Methods A total of 35 patients (mean age 68 ± 10 y...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2014-11, Vol.21 (11), p.801-808 |
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| container_title | Journal of hepato-biliary-pancreatic sciences |
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| creator | Ogawa, Takahisa Horaguchi, Jun Fujita, Naotaka Noda, Yutaka Kobayashi, Go Ito, Kei Koshita, Shinsuke Kanno, Yoshihide Masu, Kaori Sugita, Reiji |
| description | Background
The aim of this study was to evaluate the usefulness of high b‐value diffusion‐weighted magnetic resonance imaging (DWI) for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN).
Methods
A total of 35 patients (mean age 68 ± 10 years, 23 males) who had undergone DWI before surgery were included in this study. Of these 35 patients, 13 had IPMN with low‐ or intermediate‐grade dysplasia, eight had IPMN with high‐grade dysplasia, and 14 had IPMN with an associated invasive carcinoma. We evaluated the positive signal rate on DWI and the apparent diffusion coefficient (ADC) value of each pathology.
Results
The positive signal rate on DWI of IPMN with low‐ or intermediate‐grade dysplasia, of IPMN with high‐grade dysplasia, and of IPMN with an associated invasive carcinoma were 0% (0/13), 38% (3/8), and 93% (13/14), respectively. The sensitivity, specificity, and accuracy for malignancy (IPMN with high‐grade dysplasia or IPMN with an associated invasive carcinoma) using DWI were 73%, 100%, and 83%, respectively. The mean ADC value of malignancy was significantly lower than that of benignity (P = 0.002).
Conclusions
Diffusion‐weighted magnetic resonance imaging, easily applicable in addition to conventional MRI, is considered an efficient modality for evaluating the histological degree of malignancy in patients with IPMN. |
| doi_str_mv | 10.1002/jhbp.135 |
| format | Article |
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The aim of this study was to evaluate the usefulness of high b‐value diffusion‐weighted magnetic resonance imaging (DWI) for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN).
Methods
A total of 35 patients (mean age 68 ± 10 years, 23 males) who had undergone DWI before surgery were included in this study. Of these 35 patients, 13 had IPMN with low‐ or intermediate‐grade dysplasia, eight had IPMN with high‐grade dysplasia, and 14 had IPMN with an associated invasive carcinoma. We evaluated the positive signal rate on DWI and the apparent diffusion coefficient (ADC) value of each pathology.
Results
The positive signal rate on DWI of IPMN with low‐ or intermediate‐grade dysplasia, of IPMN with high‐grade dysplasia, and of IPMN with an associated invasive carcinoma were 0% (0/13), 38% (3/8), and 93% (13/14), respectively. The sensitivity, specificity, and accuracy for malignancy (IPMN with high‐grade dysplasia or IPMN with an associated invasive carcinoma) using DWI were 73%, 100%, and 83%, respectively. The mean ADC value of malignancy was significantly lower than that of benignity (P = 0.002).
Conclusions
Diffusion‐weighted magnetic resonance imaging, easily applicable in addition to conventional MRI, is considered an efficient modality for evaluating the histological degree of malignancy in patients with IPMN.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.135</identifier><identifier>PMID: 25082473</identifier><language>eng</language><publisher>Japan: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma, Mucinous - pathology ; Aged ; Carcinoma, Pancreatic Ductal - pathology ; Carcinoma, Papillary - pathology ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion-weighted magnetic resonance imaging ; Female ; Follow-Up Studies ; Humans ; Intraductal papillary mucinous neoplasm ; Male ; Neoplasm Staging - methods ; Pancreatic cystic lesion ; Pancreatic Neoplasms - pathology ; Reproducibility of Results ; Retrospective Studies</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2014-11, Vol.21 (11), p.801-808</ispartof><rights>2014 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery.</rights><rights>2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4115-ceaf754721f3e7b1ebce97433e7c5ccb791811f8103899e0f5cc2ff42ad6f1a03</citedby><cites>FETCH-LOGICAL-c4115-ceaf754721f3e7b1ebce97433e7c5ccb791811f8103899e0f5cc2ff42ad6f1a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.135$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.135$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25082473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogawa, Takahisa</creatorcontrib><creatorcontrib>Horaguchi, Jun</creatorcontrib><creatorcontrib>Fujita, Naotaka</creatorcontrib><creatorcontrib>Noda, Yutaka</creatorcontrib><creatorcontrib>Kobayashi, Go</creatorcontrib><creatorcontrib>Ito, Kei</creatorcontrib><creatorcontrib>Koshita, Shinsuke</creatorcontrib><creatorcontrib>Kanno, Yoshihide</creatorcontrib><creatorcontrib>Masu, Kaori</creatorcontrib><creatorcontrib>Sugita, Reiji</creatorcontrib><title>Diffusion-weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background
The aim of this study was to evaluate the usefulness of high b‐value diffusion‐weighted magnetic resonance imaging (DWI) for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN).
Methods
A total of 35 patients (mean age 68 ± 10 years, 23 males) who had undergone DWI before surgery were included in this study. Of these 35 patients, 13 had IPMN with low‐ or intermediate‐grade dysplasia, eight had IPMN with high‐grade dysplasia, and 14 had IPMN with an associated invasive carcinoma. We evaluated the positive signal rate on DWI and the apparent diffusion coefficient (ADC) value of each pathology.
Results
The positive signal rate on DWI of IPMN with low‐ or intermediate‐grade dysplasia, of IPMN with high‐grade dysplasia, and of IPMN with an associated invasive carcinoma were 0% (0/13), 38% (3/8), and 93% (13/14), respectively. The sensitivity, specificity, and accuracy for malignancy (IPMN with high‐grade dysplasia or IPMN with an associated invasive carcinoma) using DWI were 73%, 100%, and 83%, respectively. The mean ADC value of malignancy was significantly lower than that of benignity (P = 0.002).
Conclusions
Diffusion‐weighted magnetic resonance imaging, easily applicable in addition to conventional MRI, is considered an efficient modality for evaluating the histological degree of malignancy in patients with IPMN.</description><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Aged</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Diffusion-weighted magnetic resonance imaging</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intraductal papillary mucinous neoplasm</subject><subject>Male</subject><subject>Neoplasm Staging - methods</subject><subject>Pancreatic cystic lesion</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV2L1DAUhoso7rIu-Ask4I03XZOmbdpLHXVHWfzCD_AmpOlJm7FNaj4c57f4Z8044wiCuUnO4cnDSd4su0_wFcG4eLwZu-WK0OpWdk6ausnrtilun86sPMsuvd_gtCihLcV3s7Oiwk1RMnqe_XymlYpeW5NvQQ9jgB7NYjAQtEQOvDXCSEA69bQZkLIOwXcxRRH2ZRgBjdoHO9lBSzGhHgYHgKxKkkkP-8s7pA1aEg8meLTVYUyN4EQfZUg3FrHoaRJuh-YotbHRIwN2mYSf72V3lJg8XB73i-zji-cfVuv85s31y9WTm1yWhFS5BKFYVbKCKAqsI9BJSM-mqZCVlB1rSUOIagimTdsCVqlZKFUWoq8VEZheZI8O3sXZbxF84LP2EtJUaZLoOalJXTJGaZXQh_-gGxudSdNxwnDdYlzV7V-hdNZ7B4ovLv2g23GC-T4zvs-Mk9_CB0dh7GboT-CfhBKQH4CtnmD3XxF_tX769iA88ikW-HHihfvKa0ZZxT-_vuZfPr0r3q-rFaf0F1Lqs3w</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Ogawa, Takahisa</creator><creator>Horaguchi, Jun</creator><creator>Fujita, Naotaka</creator><creator>Noda, Yutaka</creator><creator>Kobayashi, Go</creator><creator>Ito, Kei</creator><creator>Koshita, Shinsuke</creator><creator>Kanno, Yoshihide</creator><creator>Masu, Kaori</creator><creator>Sugita, Reiji</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Diffusion-weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm</title><author>Ogawa, Takahisa ; Horaguchi, Jun ; Fujita, Naotaka ; Noda, Yutaka ; Kobayashi, Go ; Ito, Kei ; Koshita, Shinsuke ; Kanno, Yoshihide ; Masu, Kaori ; Sugita, Reiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4115-ceaf754721f3e7b1ebce97433e7c5ccb791811f8103899e0f5cc2ff42ad6f1a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Aged</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Diffusion-weighted magnetic resonance imaging</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intraductal papillary mucinous neoplasm</topic><topic>Male</topic><topic>Neoplasm Staging - methods</topic><topic>Pancreatic cystic lesion</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogawa, Takahisa</creatorcontrib><creatorcontrib>Horaguchi, Jun</creatorcontrib><creatorcontrib>Fujita, Naotaka</creatorcontrib><creatorcontrib>Noda, Yutaka</creatorcontrib><creatorcontrib>Kobayashi, Go</creatorcontrib><creatorcontrib>Ito, Kei</creatorcontrib><creatorcontrib>Koshita, Shinsuke</creatorcontrib><creatorcontrib>Kanno, Yoshihide</creatorcontrib><creatorcontrib>Masu, Kaori</creatorcontrib><creatorcontrib>Sugita, Reiji</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogawa, Takahisa</au><au>Horaguchi, Jun</au><au>Fujita, Naotaka</au><au>Noda, Yutaka</au><au>Kobayashi, Go</au><au>Ito, Kei</au><au>Koshita, Shinsuke</au><au>Kanno, Yoshihide</au><au>Masu, Kaori</au><au>Sugita, Reiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion-weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2014-11</date><risdate>2014</risdate><volume>21</volume><issue>11</issue><spage>801</spage><epage>808</epage><pages>801-808</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background
The aim of this study was to evaluate the usefulness of high b‐value diffusion‐weighted magnetic resonance imaging (DWI) for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN).
Methods
A total of 35 patients (mean age 68 ± 10 years, 23 males) who had undergone DWI before surgery were included in this study. Of these 35 patients, 13 had IPMN with low‐ or intermediate‐grade dysplasia, eight had IPMN with high‐grade dysplasia, and 14 had IPMN with an associated invasive carcinoma. We evaluated the positive signal rate on DWI and the apparent diffusion coefficient (ADC) value of each pathology.
Results
The positive signal rate on DWI of IPMN with low‐ or intermediate‐grade dysplasia, of IPMN with high‐grade dysplasia, and of IPMN with an associated invasive carcinoma were 0% (0/13), 38% (3/8), and 93% (13/14), respectively. The sensitivity, specificity, and accuracy for malignancy (IPMN with high‐grade dysplasia or IPMN with an associated invasive carcinoma) using DWI were 73%, 100%, and 83%, respectively. The mean ADC value of malignancy was significantly lower than that of benignity (P = 0.002).
Conclusions
Diffusion‐weighted magnetic resonance imaging, easily applicable in addition to conventional MRI, is considered an efficient modality for evaluating the histological degree of malignancy in patients with IPMN.</abstract><cop>Japan</cop><pub>Blackwell Publishing Ltd</pub><pmid>25082473</pmid><doi>10.1002/jhbp.135</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1868-6974 |
| ispartof | Journal of hepato-biliary-pancreatic sciences, 2014-11, Vol.21 (11), p.801-808 |
| issn | 1868-6974 1868-6982 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenocarcinoma, Mucinous - pathology Aged Carcinoma, Pancreatic Ductal - pathology Carcinoma, Papillary - pathology Diffusion Magnetic Resonance Imaging - methods Diffusion-weighted magnetic resonance imaging Female Follow-Up Studies Humans Intraductal papillary mucinous neoplasm Male Neoplasm Staging - methods Pancreatic cystic lesion Pancreatic Neoplasms - pathology Reproducibility of Results Retrospective Studies |
| title | Diffusion-weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm |
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