Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery
In recent years significant progress has been made to improve particle deposition in the lung. However, the development of strategies to overcome the air–blood lung barrier is still needed. The combination of complex in vitro models and sophisticated particulate carriers is promising as a strategy b...
Gespeichert in:
| Veröffentlicht in: | Advanced drug delivery reviews 2014-08, Vol.75, p.129-140 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 140 |
|---|---|
| container_issue | |
| container_start_page | 129 |
| container_title | Advanced drug delivery reviews |
| container_volume | 75 |
| creator | de Souza Carvalho, Cristiane Daum, Nicole Lehr, Claus-Michael |
| description | In recent years significant progress has been made to improve particle deposition in the lung. However, the development of strategies to overcome the air–blood lung barrier is still needed. The combination of complex in vitro models and sophisticated particulate carriers is promising as a strategy by which that goal could be achieved. In this review we discuss currently available in vitro lung models, including some recent tissue-engineering approaches, as well as the challenges associated to implement such complex in vitro systems. Furthermore, we discuss available carrier technologies, often based on nanotechnology, to target specific regions of the lungs and to overcome the respective biological barriers, ideally resulting in safe and effective delivery to the desired pulmonary destination.
[Display omitted] |
| doi_str_mv | 10.1016/j.addr.2014.05.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1616476685</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169409X14001264</els_id><sourcerecordid>1616476685</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-7e7f0930f3bd834c6ba9c6e6d693949066500eb45f4304e8969f4e1748590403</originalsourceid><addsrcrecordid>eNp9kLFu2zAURYkiReOk_YEOBccsUh8lihKDLoHRNgUCdMnQjaDIJ5sGJTqk5CBrvzx0nWbMdId37sXDIeQzg5IBE193pbY2lhUwXkJT5nhHVqxrq6KrJD8jqwzJgoP8c04uUtoBsKoV8IGcV7zrMt6syN-1jtFhpG6aMWozuzAl-ujmLZ23SHsXfNg4oz3tT2CiYfh38su0uaY39qAngzb36cHNMdAxWPSJ6slSs9Xe47TBRIcQ6X7xY5h0fKI2LhuaMXfA-PSRvB-0T_jpJS_J_Y_v9-vb4u73z1_rm7vC8ErMRYvtALKGoe5tV3Mjei2NQGGFrCWXIEQDgD1vBl4Dx04KOXBkLe8aCRzqS3J1mt3H8LBgmtXokkHv9YRhSYoJJngrRNdktDqhJoaUIg5qH92YH1cM1FG92qmjenVUr6BROXLpy8v-0o9oXyv_XWfg2wnIevCQVapkHB7luYhmVja4t_afAdIslj4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1616476685</pqid></control><display><type>article</type><title>Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>de Souza Carvalho, Cristiane ; Daum, Nicole ; Lehr, Claus-Michael</creator><creatorcontrib>de Souza Carvalho, Cristiane ; Daum, Nicole ; Lehr, Claus-Michael</creatorcontrib><description>In recent years significant progress has been made to improve particle deposition in the lung. However, the development of strategies to overcome the air–blood lung barrier is still needed. The combination of complex in vitro models and sophisticated particulate carriers is promising as a strategy by which that goal could be achieved. In this review we discuss currently available in vitro lung models, including some recent tissue-engineering approaches, as well as the challenges associated to implement such complex in vitro systems. Furthermore, we discuss available carrier technologies, often based on nanotechnology, to target specific regions of the lungs and to overcome the respective biological barriers, ideally resulting in safe and effective delivery to the desired pulmonary destination.
[Display omitted]</description><identifier>ISSN: 0169-409X</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2014.05.014</identifier><identifier>PMID: 24880145</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>3D cell culture ; Administration, Inhalation ; Air ; Air–blood barrier ; Animals ; Blood ; Cell Culture Techniques ; Challenge ; Drug Carriers - administration & dosage ; Humans ; Lung - metabolism ; Models, Biological ; Mucus ; Particles ; Surfactant ; Tissue Engineering</subject><ispartof>Advanced drug delivery reviews, 2014-08, Vol.75, p.129-140</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-7e7f0930f3bd834c6ba9c6e6d693949066500eb45f4304e8969f4e1748590403</citedby><cites>FETCH-LOGICAL-c426t-7e7f0930f3bd834c6ba9c6e6d693949066500eb45f4304e8969f4e1748590403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169409X14001264$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24880145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Souza Carvalho, Cristiane</creatorcontrib><creatorcontrib>Daum, Nicole</creatorcontrib><creatorcontrib>Lehr, Claus-Michael</creatorcontrib><title>Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>In recent years significant progress has been made to improve particle deposition in the lung. However, the development of strategies to overcome the air–blood lung barrier is still needed. The combination of complex in vitro models and sophisticated particulate carriers is promising as a strategy by which that goal could be achieved. In this review we discuss currently available in vitro lung models, including some recent tissue-engineering approaches, as well as the challenges associated to implement such complex in vitro systems. Furthermore, we discuss available carrier technologies, often based on nanotechnology, to target specific regions of the lungs and to overcome the respective biological barriers, ideally resulting in safe and effective delivery to the desired pulmonary destination.
[Display omitted]</description><subject>3D cell culture</subject><subject>Administration, Inhalation</subject><subject>Air</subject><subject>Air–blood barrier</subject><subject>Animals</subject><subject>Blood</subject><subject>Cell Culture Techniques</subject><subject>Challenge</subject><subject>Drug Carriers - administration & dosage</subject><subject>Humans</subject><subject>Lung - metabolism</subject><subject>Models, Biological</subject><subject>Mucus</subject><subject>Particles</subject><subject>Surfactant</subject><subject>Tissue Engineering</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLFu2zAURYkiReOk_YEOBccsUh8lihKDLoHRNgUCdMnQjaDIJ5sGJTqk5CBrvzx0nWbMdId37sXDIeQzg5IBE193pbY2lhUwXkJT5nhHVqxrq6KrJD8jqwzJgoP8c04uUtoBsKoV8IGcV7zrMt6syN-1jtFhpG6aMWozuzAl-ujmLZ23SHsXfNg4oz3tT2CiYfh38su0uaY39qAngzb36cHNMdAxWPSJ6slSs9Xe47TBRIcQ6X7xY5h0fKI2LhuaMXfA-PSRvB-0T_jpJS_J_Y_v9-vb4u73z1_rm7vC8ErMRYvtALKGoe5tV3Mjei2NQGGFrCWXIEQDgD1vBl4Dx04KOXBkLe8aCRzqS3J1mt3H8LBgmtXokkHv9YRhSYoJJngrRNdktDqhJoaUIg5qH92YH1cM1FG92qmjenVUr6BROXLpy8v-0o9oXyv_XWfg2wnIevCQVapkHB7luYhmVja4t_afAdIslj4</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>de Souza Carvalho, Cristiane</creator><creator>Daum, Nicole</creator><creator>Lehr, Claus-Michael</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery</title><author>de Souza Carvalho, Cristiane ; Daum, Nicole ; Lehr, Claus-Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-7e7f0930f3bd834c6ba9c6e6d693949066500eb45f4304e8969f4e1748590403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>3D cell culture</topic><topic>Administration, Inhalation</topic><topic>Air</topic><topic>Air–blood barrier</topic><topic>Animals</topic><topic>Blood</topic><topic>Cell Culture Techniques</topic><topic>Challenge</topic><topic>Drug Carriers - administration & dosage</topic><topic>Humans</topic><topic>Lung - metabolism</topic><topic>Models, Biological</topic><topic>Mucus</topic><topic>Particles</topic><topic>Surfactant</topic><topic>Tissue Engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Souza Carvalho, Cristiane</creatorcontrib><creatorcontrib>Daum, Nicole</creatorcontrib><creatorcontrib>Lehr, Claus-Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Souza Carvalho, Cristiane</au><au>Daum, Nicole</au><au>Lehr, Claus-Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2014-08</date><risdate>2014</risdate><volume>75</volume><spage>129</spage><epage>140</epage><pages>129-140</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>In recent years significant progress has been made to improve particle deposition in the lung. However, the development of strategies to overcome the air–blood lung barrier is still needed. The combination of complex in vitro models and sophisticated particulate carriers is promising as a strategy by which that goal could be achieved. In this review we discuss currently available in vitro lung models, including some recent tissue-engineering approaches, as well as the challenges associated to implement such complex in vitro systems. Furthermore, we discuss available carrier technologies, often based on nanotechnology, to target specific regions of the lungs and to overcome the respective biological barriers, ideally resulting in safe and effective delivery to the desired pulmonary destination.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24880145</pmid><doi>10.1016/j.addr.2014.05.014</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2014-08, Vol.75, p.129-140 |
| issn | 0169-409X 1872-8294 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1616476685 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3D cell culture Administration, Inhalation Air Air–blood barrier Animals Blood Cell Culture Techniques Challenge Drug Carriers - administration & dosage Humans Lung - metabolism Models, Biological Mucus Particles Surfactant Tissue Engineering |
| title | Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A38%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carrier%20interactions%20with%20the%20biological%20barriers%20of%20the%20lung:%20Advanced%20in%20vitro%20models%20and%20challenges%20for%20pulmonary%20drug%20delivery&rft.jtitle=Advanced%20drug%20delivery%20reviews&rft.au=de%20Souza%20Carvalho,%20Cristiane&rft.date=2014-08&rft.volume=75&rft.spage=129&rft.epage=140&rft.pages=129-140&rft.issn=0169-409X&rft.eissn=1872-8294&rft_id=info:doi/10.1016/j.addr.2014.05.014&rft_dat=%3Cproquest_cross%3E1616476685%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1616476685&rft_id=info:pmid/24880145&rft_els_id=S0169409X14001264&rfr_iscdi=true |