The Role of the Dorsal Root Ganglion in the Development of Neuropathic Pain

Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of as a passive organ not involved in the development of abnormal aberrent neuropathic pain (NP), but merely metabolically “supporting” physiologic functions between the peripheral nervous system (PNS) and the c...

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Veröffentlicht in:	Pain medicine (Malden, Mass.) Mass.), 2014-10, Vol.15 (10), p.1669-1685
1. Verfasser:	Krames, Elliot S.
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Sprache:	eng
Schlagworte:	Animals Dorsal Root Ganglion Ganglia, Spinal Humans Inflammation Injury Nervous system Neuralgia Neuropathic Pain Pain Pathophysiology Peripheral Afferant Fiber Spinal cord
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container_title	Pain medicine (Malden, Mass.)
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creator	Krames, Elliot S.
description	Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of as a passive organ not involved in the development of abnormal aberrent neuropathic pain (NP), but merely metabolically “supporting” physiologic functions between the peripheral nervous system (PNS) and the central nervous system (CNS). New information regarding metabolic change within the DRG has dispelled this supportive passive role and suggests that the DRG is an active, not a passive, organ, in the process of the development of chronic pain. Methods A review of the anatomic and physiologic literature utilizing PubMed and Google Scholar was performed to create a review of the anatomic and physiologic foundations for the development of NP after peripheral afferent fiber injury. Conclusions The DRG is as involved in the process of generating NP as is the nociceptor and the dorsal horn of the spinal cord.
doi_str_mv	10.1111/pme.12413
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New information regarding metabolic change within the DRG has dispelled this supportive passive role and suggests that the DRG is an active, not a passive, organ, in the process of the development of chronic pain. Methods A review of the anatomic and physiologic literature utilizing PubMed and Google Scholar was performed to create a review of the anatomic and physiologic foundations for the development of NP after peripheral afferent fiber injury. Conclusions The DRG is as involved in the process of generating NP as is the nociceptor and the dorsal horn of the spinal cord.</description><identifier>ISSN: 1526-2375</identifier><identifier>EISSN: 1526-4637</identifier><identifier>DOI: 10.1111/pme.12413</identifier><identifier>PMID: 24641192</identifier><identifier>CODEN: PMAEAP</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Dorsal Root Ganglion ; Ganglia, Spinal ; Humans ; Inflammation ; Injury ; Nervous system ; Neuralgia ; Neuropathic Pain ; Pain ; Pathophysiology ; Peripheral Afferant Fiber ; Spinal cord</subject><ispartof>Pain medicine (Malden, Mass.), 2014-10, Vol.15 (10), p.1669-1685</ispartof><rights>Wiley Periodicals, Inc</rights><rights>Wiley Periodicals, Inc.</rights><rights>2014 American Academy of Pain Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4543-baa03a0fe2ecb6459e39d94446b9611d6947d5ce54ad7f6be242fde5e51243223</citedby><cites>FETCH-LOGICAL-c4543-baa03a0fe2ecb6459e39d94446b9611d6947d5ce54ad7f6be242fde5e51243223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpme.12413$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpme.12413$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24641192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krames, Elliot S.</creatorcontrib><title>The Role of the Dorsal Root Ganglion in the Development of Neuropathic Pain</title><title>Pain medicine (Malden, Mass.)</title><addtitle>Pain Med</addtitle><description>Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of as a passive organ not involved in the development of abnormal aberrent neuropathic pain (NP), but merely metabolically “supporting” physiologic functions between the peripheral nervous system (PNS) and the central nervous system (CNS). New information regarding metabolic change within the DRG has dispelled this supportive passive role and suggests that the DRG is an active, not a passive, organ, in the process of the development of chronic pain. Methods A review of the anatomic and physiologic literature utilizing PubMed and Google Scholar was performed to create a review of the anatomic and physiologic foundations for the development of NP after peripheral afferent fiber injury. 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New information regarding metabolic change within the DRG has dispelled this supportive passive role and suggests that the DRG is an active, not a passive, organ, in the process of the development of chronic pain. Methods A review of the anatomic and physiologic literature utilizing PubMed and Google Scholar was performed to create a review of the anatomic and physiologic foundations for the development of NP after peripheral afferent fiber injury. Conclusions The DRG is as involved in the process of generating NP as is the nociceptor and the dorsal horn of the spinal cord.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>24641192</pmid><doi>10.1111/pme.12413</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record>
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subjects	Animals Dorsal Root Ganglion Ganglia, Spinal Humans Inflammation Injury Nervous system Neuralgia Neuropathic Pain Pain Pathophysiology Peripheral Afferant Fiber Spinal cord
title	The Role of the Dorsal Root Ganglion in the Development of Neuropathic Pain
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