Effects of 2, 4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish ( Ictalurus punctatus)
Channel catfish ( Ictalurus punctatus) exposed to a mixture of picloram and 2, 4-dichlorophenoxyacetic acid (2, 4-D) for 10 days displayed increased activities of hepatic ethoxyresorufin O-deethylase (EROD), decreased serum chloride concentrations and decreased liver/body weight ratios. These change...
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| Veröffentlicht in: | Toxicology letters 1991-06, Vol.57 (1), p.65-72 |
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| creator | Gallagher, Evan P. Di Giulio, Richard T. |
| description | Channel catfish (
Ictalurus punctatus) exposed to a mixture of picloram and 2, 4-dichlorophenoxyacetic acid (2, 4-D) for 10 days displayed increased activities of hepatic ethoxyresorufin
O-deethylase (EROD), decreased serum chloride concentrations and decreased liver/body weight ratios. These changes were not observed in fish exposed to either compound alone. Neither compound, nor their mixture, increased hepatic peroxisomal catalase or lauroyl CoA oxidase activities. The results of this study indicate that 10-day exposure of 2, 4-D or picloram does not induce peroxisomal enzymes in channel catfish; however, exposure to a mixture of 2, 4-D and picloram may cause physiological effects to catfish not observed with either compound alone. |
| doi_str_mv | 10.1016/0378-4274(91)90120-U |
| format | Article |
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Ictalurus punctatus) exposed to a mixture of picloram and 2, 4-dichlorophenoxyacetic acid (2, 4-D) for 10 days displayed increased activities of hepatic ethoxyresorufin
O-deethylase (EROD), decreased serum chloride concentrations and decreased liver/body weight ratios. These changes were not observed in fish exposed to either compound alone. Neither compound, nor their mixture, increased hepatic peroxisomal catalase or lauroyl CoA oxidase activities. The results of this study indicate that 10-day exposure of 2, 4-D or picloram does not induce peroxisomal enzymes in channel catfish; however, exposure to a mixture of 2, 4-D and picloram may cause physiological effects to catfish not observed with either compound alone.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(91)90120-U</identifier><identifier>PMID: 2048162</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>2, 4-Dichlorophenoxyacetic acid ; 2,4-D ; 2,4-Dichlorophenoxyacetic Acid - toxicity ; Acyl Coenzyme A - analysis ; Animals ; Biotransformation enzymes ; Body Weight - drug effects ; Catalase - analysis ; Channel catfish ; Chlorides - blood ; Cytochrome P-450 CYP1A1 ; Cytochrome P-450 Enzyme System - analysis ; Cytochrome P-450 Enzyme System - blood ; enzyme activity ; enzymes ; epigenetics ; ethoxyresorufin o-deethylase ; Freshwater ; glutathione transferase ; Glutathione Transferase - analysis ; herbicide mixtures ; Ictaluridae - metabolism ; Ictalurus punctatus ; liver ; Liver - drug effects ; Liver - enzymology ; metabolic detoxification ; Microbodies - drug effects ; Microbodies - enzymology ; nontarget organisms ; Organ Size - drug effects ; organelles ; Oxidoreductases - analysis ; Oxidoreductases - blood ; peroxisome proliferation ; Peroxisomes ; Picloram ; Picloram - toxicity</subject><ispartof>Toxicology letters, 1991-06, Vol.57 (1), p.65-72</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-bc389e233c595eb9ee069289b468f9e8a0cd1d7abdf1df1596365262f0b89643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(91)90120-U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2048162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallagher, Evan P.</creatorcontrib><creatorcontrib>Di Giulio, Richard T.</creatorcontrib><title>Effects of 2, 4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish ( Ictalurus punctatus)</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Channel catfish (
Ictalurus punctatus) exposed to a mixture of picloram and 2, 4-dichlorophenoxyacetic acid (2, 4-D) for 10 days displayed increased activities of hepatic ethoxyresorufin
O-deethylase (EROD), decreased serum chloride concentrations and decreased liver/body weight ratios. These changes were not observed in fish exposed to either compound alone. Neither compound, nor their mixture, increased hepatic peroxisomal catalase or lauroyl CoA oxidase activities. The results of this study indicate that 10-day exposure of 2, 4-D or picloram does not induce peroxisomal enzymes in channel catfish; however, exposure to a mixture of 2, 4-D and picloram may cause physiological effects to catfish not observed with either compound alone.</description><subject>2, 4-Dichlorophenoxyacetic acid</subject><subject>2,4-D</subject><subject>2,4-Dichlorophenoxyacetic Acid - toxicity</subject><subject>Acyl Coenzyme A - analysis</subject><subject>Animals</subject><subject>Biotransformation enzymes</subject><subject>Body Weight - drug effects</subject><subject>Catalase - analysis</subject><subject>Channel catfish</subject><subject>Chlorides - blood</subject><subject>Cytochrome P-450 CYP1A1</subject><subject>Cytochrome P-450 Enzyme System - analysis</subject><subject>Cytochrome P-450 Enzyme System - blood</subject><subject>enzyme activity</subject><subject>enzymes</subject><subject>epigenetics</subject><subject>ethoxyresorufin o-deethylase</subject><subject>Freshwater</subject><subject>glutathione transferase</subject><subject>Glutathione Transferase - analysis</subject><subject>herbicide mixtures</subject><subject>Ictaluridae - metabolism</subject><subject>Ictalurus punctatus</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>metabolic detoxification</subject><subject>Microbodies - drug effects</subject><subject>Microbodies - enzymology</subject><subject>nontarget organisms</subject><subject>Organ Size - drug effects</subject><subject>organelles</subject><subject>Oxidoreductases - analysis</subject><subject>Oxidoreductases - blood</subject><subject>peroxisome proliferation</subject><subject>Peroxisomes</subject><subject>Picloram</subject><subject>Picloram - toxicity</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEUhYModVv9B4p5khY6mmQymclLQUq1hYIPdp9DJnPjRmaSMcmUrn_Gv9psd-lj4UIunO8ewjkIfaDkCyVUfCV121WctfxU0jNJKCPV-hVa0a6VVU2FfI1Wz8hbdJzSH0KI4KI5QkeM8I4KtkL_r6wFkxMOFrNzzKvBmc0YYpg34MPDVhvIzmBt3IC1H_DsTFH1hIPHvQs5ap9siJPOLvhzPEMMDy6FSY9PeIK4TBj8v-0ExSS7e5cdJOw8NhvtPYzY6Gxd2uBTfGOyHpe4JDwvvux5SWfv0BurxwTvD-8Juvt-dXd5Xd3-_HFz-e22MpyyXPWm7iSwujaNbKCXAERI1smei85K6DQxAx1a3Q-WlmmkqEXDBLOk76Tg9Qn6vLedY_i7QMpqcsnAOGoPYUmKipIWY10B-R40MaQUwao5uknHraJE7WpRu8zVLnMlqXqqRa3L2ceD_9JPMDwfHXoo-qe9bnVQ-nd0Sa1_MUJrQltOJKWFuNgTUFK4dxBVMg68gcHFUqAagnv5C4-6_6ir</recordid><startdate>19910601</startdate><enddate>19910601</enddate><creator>Gallagher, Evan P.</creator><creator>Di Giulio, Richard T.</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>H98</scope><scope>L.G</scope></search><sort><creationdate>19910601</creationdate><title>Effects of 2, 4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish ( Ictalurus punctatus)</title><author>Gallagher, Evan P. ; Di Giulio, Richard T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-bc389e233c595eb9ee069289b468f9e8a0cd1d7abdf1df1596365262f0b89643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>2, 4-Dichlorophenoxyacetic acid</topic><topic>2,4-D</topic><topic>2,4-Dichlorophenoxyacetic Acid - toxicity</topic><topic>Acyl Coenzyme A - analysis</topic><topic>Animals</topic><topic>Biotransformation enzymes</topic><topic>Body Weight - drug effects</topic><topic>Catalase - analysis</topic><topic>Channel catfish</topic><topic>Chlorides - blood</topic><topic>Cytochrome P-450 CYP1A1</topic><topic>Cytochrome P-450 Enzyme System - analysis</topic><topic>Cytochrome P-450 Enzyme System - blood</topic><topic>enzyme activity</topic><topic>enzymes</topic><topic>epigenetics</topic><topic>ethoxyresorufin o-deethylase</topic><topic>Freshwater</topic><topic>glutathione transferase</topic><topic>Glutathione Transferase - analysis</topic><topic>herbicide mixtures</topic><topic>Ictaluridae - metabolism</topic><topic>Ictalurus punctatus</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>metabolic detoxification</topic><topic>Microbodies - drug effects</topic><topic>Microbodies - enzymology</topic><topic>nontarget organisms</topic><topic>Organ Size - drug effects</topic><topic>organelles</topic><topic>Oxidoreductases - analysis</topic><topic>Oxidoreductases - blood</topic><topic>peroxisome proliferation</topic><topic>Peroxisomes</topic><topic>Picloram</topic><topic>Picloram - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallagher, Evan P.</creatorcontrib><creatorcontrib>Di Giulio, Richard T.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallagher, Evan P.</au><au>Di Giulio, Richard T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 2, 4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish ( Ictalurus punctatus)</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1991-06-01</date><risdate>1991</risdate><volume>57</volume><issue>1</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>Channel catfish (
Ictalurus punctatus) exposed to a mixture of picloram and 2, 4-dichlorophenoxyacetic acid (2, 4-D) for 10 days displayed increased activities of hepatic ethoxyresorufin
O-deethylase (EROD), decreased serum chloride concentrations and decreased liver/body weight ratios. These changes were not observed in fish exposed to either compound alone. Neither compound, nor their mixture, increased hepatic peroxisomal catalase or lauroyl CoA oxidase activities. The results of this study indicate that 10-day exposure of 2, 4-D or picloram does not induce peroxisomal enzymes in channel catfish; however, exposure to a mixture of 2, 4-D and picloram may cause physiological effects to catfish not observed with either compound alone.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>2048162</pmid><doi>10.1016/0378-4274(91)90120-U</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxicology letters, 1991-06, Vol.57 (1), p.65-72 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 2, 4-Dichlorophenoxyacetic acid 2,4-D 2,4-Dichlorophenoxyacetic Acid - toxicity Acyl Coenzyme A - analysis Animals Biotransformation enzymes Body Weight - drug effects Catalase - analysis Channel catfish Chlorides - blood Cytochrome P-450 CYP1A1 Cytochrome P-450 Enzyme System - analysis Cytochrome P-450 Enzyme System - blood enzyme activity enzymes epigenetics ethoxyresorufin o-deethylase Freshwater glutathione transferase Glutathione Transferase - analysis herbicide mixtures Ictaluridae - metabolism Ictalurus punctatus liver Liver - drug effects Liver - enzymology metabolic detoxification Microbodies - drug effects Microbodies - enzymology nontarget organisms Organ Size - drug effects organelles Oxidoreductases - analysis Oxidoreductases - blood peroxisome proliferation Peroxisomes Picloram Picloram - toxicity |
| title | Effects of 2, 4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish ( Ictalurus punctatus) |
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