Caffeine enhances micturition through neuronal activation in micturition centers
Caffeine may promote incontinence through its diuretic effect, particularly in individuals with underlying detrusor overactivity, in addition to increasing muscle contraction of the bladder smooth muscle. Caffeine may also affect bladder function via central micturition centers, including the medial...
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| Veröffentlicht in: | Molecular medicine reports 2014-12, Vol.10 (6), p.2931-2936 |
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| creator | CHO, YOUNG-SAM KO, IL-GYU KIM, SUNG-EUN HWAN, LAKKYONG SHIN, MAL-SOON KIM, CHANG-JU KIM, SANG-HOON JIN, JUN-JANG CHUNG, JUN-YOUNG KIM, KHAE-HAWN |
| description | Caffeine may promote incontinence through its diuretic effect, particularly in individuals with underlying detrusor overactivity, in addition to increasing muscle contraction of the bladder smooth muscle. Caffeine may also affect bladder function via central micturition centers, including the medial preoptic area, ventrolateral periaqueductal gray, and pontine micturition center. However, the biochemical mechanisms of caffeine in central micturition centers affecting bladder function remain unclear. In the present study, the effects of caffeine on the central micturition reflex were investigated by measuring the degree of neuronal activation, and by quantifying nerve growth factor (NGF) expression in rats. Following caffeine administration for 14 days, a urodynamic study was performed to assess the changes to bladder function. Subsequently, immunohistochemical staining to identify the expression of c-Fos and NGF in the central micturition areas was performed. Ingestion of caffeine increased bladder smooth muscle contraction pressure and time as determined by cystometry. Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine. The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine. These results suggest that caffeine facilitates bladder instability through enhancing neuronal activation in the central micturition areas. |
| doi_str_mv | 10.3892/mmr.2014.2646 |
| format | Article |
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Caffeine may also affect bladder function via central micturition centers, including the medial preoptic area, ventrolateral periaqueductal gray, and pontine micturition center. However, the biochemical mechanisms of caffeine in central micturition centers affecting bladder function remain unclear. In the present study, the effects of caffeine on the central micturition reflex were investigated by measuring the degree of neuronal activation, and by quantifying nerve growth factor (NGF) expression in rats. Following caffeine administration for 14 days, a urodynamic study was performed to assess the changes to bladder function. Subsequently, immunohistochemical staining to identify the expression of c-Fos and NGF in the central micturition areas was performed. Ingestion of caffeine increased bladder smooth muscle contraction pressure and time as determined by cystometry. Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine. The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine. These results suggest that caffeine facilitates bladder instability through enhancing neuronal activation in the central micturition areas.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2014.2646</identifier><identifier>PMID: 25323389</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; Bladder ; c-Fos ; c-Fos protein ; Caffeine ; Caffeine - pharmacology ; central micturition center ; Female ; Females ; Genetic aspects ; Muscle contraction ; Muscle Contraction - drug effects ; Muscle Contraction - genetics ; Muscle, Smooth - drug effects ; Nerve growth factor ; Nerve Growth Factor - genetics ; neuronal activation ; Periaqueductal gray area ; Physiological aspects ; Preoptic area ; Pressure ; Proto-Oncogene Proteins c-fos - genetics ; Rats ; Rats, Sprague-Dawley ; Risk factors ; Rodents ; Smooth muscle ; Studies ; Urinary bladder ; Urinary Bladder - drug effects ; Urination ; Urination - drug effects ; Urination - genetics ; Urine ; Urodynamics - drug effects ; Urodynamics - genetics ; Urogenital system</subject><ispartof>Molecular medicine reports, 2014-12, Vol.10 (6), p.2931-2936</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-236747be5e016eaf96a650d38ce874ecd866f690453a09f9103f724d9aaff4f93</citedby><cites>FETCH-LOGICAL-c459t-236747be5e016eaf96a650d38ce874ecd866f690453a09f9103f724d9aaff4f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25323389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHO, YOUNG-SAM</creatorcontrib><creatorcontrib>KO, IL-GYU</creatorcontrib><creatorcontrib>KIM, SUNG-EUN</creatorcontrib><creatorcontrib>HWAN, LAKKYONG</creatorcontrib><creatorcontrib>SHIN, MAL-SOON</creatorcontrib><creatorcontrib>KIM, CHANG-JU</creatorcontrib><creatorcontrib>KIM, SANG-HOON</creatorcontrib><creatorcontrib>JIN, JUN-JANG</creatorcontrib><creatorcontrib>CHUNG, JUN-YOUNG</creatorcontrib><creatorcontrib>KIM, KHAE-HAWN</creatorcontrib><title>Caffeine enhances micturition through neuronal activation in micturition centers</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Caffeine may promote incontinence through its diuretic effect, particularly in individuals with underlying detrusor overactivity, in addition to increasing muscle contraction of the bladder smooth muscle. Caffeine may also affect bladder function via central micturition centers, including the medial preoptic area, ventrolateral periaqueductal gray, and pontine micturition center. However, the biochemical mechanisms of caffeine in central micturition centers affecting bladder function remain unclear. In the present study, the effects of caffeine on the central micturition reflex were investigated by measuring the degree of neuronal activation, and by quantifying nerve growth factor (NGF) expression in rats. Following caffeine administration for 14 days, a urodynamic study was performed to assess the changes to bladder function. Subsequently, immunohistochemical staining to identify the expression of c-Fos and NGF in the central micturition areas was performed. Ingestion of caffeine increased bladder smooth muscle contraction pressure and time as determined by cystometry. Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine. The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine. These results suggest that caffeine facilitates bladder instability through enhancing neuronal activation in the central micturition areas.</description><subject>Animals</subject><subject>Bladder</subject><subject>c-Fos</subject><subject>c-Fos protein</subject><subject>Caffeine</subject><subject>Caffeine - pharmacology</subject><subject>central micturition center</subject><subject>Female</subject><subject>Females</subject><subject>Genetic aspects</subject><subject>Muscle contraction</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - genetics</subject><subject>Muscle, Smooth - drug effects</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factor - genetics</subject><subject>neuronal activation</subject><subject>Periaqueductal gray area</subject><subject>Physiological aspects</subject><subject>Preoptic area</subject><subject>Pressure</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Studies</subject><subject>Urinary bladder</subject><subject>Urinary Bladder - drug effects</subject><subject>Urination</subject><subject>Urination - drug effects</subject><subject>Urination - genetics</subject><subject>Urine</subject><subject>Urodynamics - drug effects</subject><subject>Urodynamics - genetics</subject><subject>Urogenital system</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc1rHCEYhyU0NB_tMdcw0ENymY3fMx7D0qSFQHpoz2Kc112XGd3oTKD_fZzuZktK8aDo8_589UHoguAFaxW9GYa0oJjwBZVcHqFT0ihSM4z5h_2aKtWcoLOcNxhLQYX6iE6oYJSV8lP0Y2mcAx-ggrA2wUKuBm_HKfnRx1CN6xSn1boKMKUYTF8ZO_oX8-fMh3eohTBCyp_QsTN9hs_7-Rz9uvv6c_mtfni8_768fagtF2qsKZMNb55AACYSjFPSSIE71lpoGw62a6V0UmEumMHKKYKZayjvlCn9cqfYObre5W5TfJ4gj3rw2ULfmwBxyppIIhouMKcF_fIPuolTKq8plGKUS0Zb8pdamR60Dy6Oydg5VN9yTCgRsp2vXfyHKqOD8hkxgPNl_11BvSuwKeacwOlt8oNJvzXBejaoi0E9G9SzwcJf7pudngboDvSbsgJc7YC8NaHzXcwHpiTVBNdYFumMsFe86qJi</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>CHO, YOUNG-SAM</creator><creator>KO, IL-GYU</creator><creator>KIM, SUNG-EUN</creator><creator>HWAN, LAKKYONG</creator><creator>SHIN, MAL-SOON</creator><creator>KIM, CHANG-JU</creator><creator>KIM, SANG-HOON</creator><creator>JIN, JUN-JANG</creator><creator>CHUNG, JUN-YOUNG</creator><creator>KIM, KHAE-HAWN</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Caffeine enhances micturition through neuronal activation in micturition centers</title><author>CHO, YOUNG-SAM ; KO, IL-GYU ; KIM, SUNG-EUN ; HWAN, LAKKYONG ; SHIN, MAL-SOON ; KIM, CHANG-JU ; KIM, SANG-HOON ; JIN, JUN-JANG ; CHUNG, JUN-YOUNG ; KIM, KHAE-HAWN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-236747be5e016eaf96a650d38ce874ecd866f690453a09f9103f724d9aaff4f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Bladder</topic><topic>c-Fos</topic><topic>c-Fos protein</topic><topic>Caffeine</topic><topic>Caffeine - pharmacology</topic><topic>central micturition center</topic><topic>Female</topic><topic>Females</topic><topic>Genetic aspects</topic><topic>Muscle contraction</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - genetics</topic><topic>Muscle, Smooth - drug effects</topic><topic>Nerve growth factor</topic><topic>Nerve Growth Factor - genetics</topic><topic>neuronal activation</topic><topic>Periaqueductal gray area</topic><topic>Physiological aspects</topic><topic>Preoptic area</topic><topic>Pressure</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Smooth muscle</topic><topic>Studies</topic><topic>Urinary bladder</topic><topic>Urinary Bladder - drug effects</topic><topic>Urination</topic><topic>Urination - drug effects</topic><topic>Urination - genetics</topic><topic>Urine</topic><topic>Urodynamics - drug effects</topic><topic>Urodynamics - genetics</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHO, YOUNG-SAM</creatorcontrib><creatorcontrib>KO, IL-GYU</creatorcontrib><creatorcontrib>KIM, SUNG-EUN</creatorcontrib><creatorcontrib>HWAN, LAKKYONG</creatorcontrib><creatorcontrib>SHIN, MAL-SOON</creatorcontrib><creatorcontrib>KIM, CHANG-JU</creatorcontrib><creatorcontrib>KIM, SANG-HOON</creatorcontrib><creatorcontrib>JIN, JUN-JANG</creatorcontrib><creatorcontrib>CHUNG, JUN-YOUNG</creatorcontrib><creatorcontrib>KIM, KHAE-HAWN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHO, YOUNG-SAM</au><au>KO, IL-GYU</au><au>KIM, SUNG-EUN</au><au>HWAN, LAKKYONG</au><au>SHIN, MAL-SOON</au><au>KIM, CHANG-JU</au><au>KIM, SANG-HOON</au><au>JIN, JUN-JANG</au><au>CHUNG, JUN-YOUNG</au><au>KIM, KHAE-HAWN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeine enhances micturition through neuronal activation in micturition centers</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>10</volume><issue>6</issue><spage>2931</spage><epage>2936</epage><pages>2931-2936</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Caffeine may promote incontinence through its diuretic effect, particularly in individuals with underlying detrusor overactivity, in addition to increasing muscle contraction of the bladder smooth muscle. Caffeine may also affect bladder function via central micturition centers, including the medial preoptic area, ventrolateral periaqueductal gray, and pontine micturition center. However, the biochemical mechanisms of caffeine in central micturition centers affecting bladder function remain unclear. In the present study, the effects of caffeine on the central micturition reflex were investigated by measuring the degree of neuronal activation, and by quantifying nerve growth factor (NGF) expression in rats. Following caffeine administration for 14 days, a urodynamic study was performed to assess the changes to bladder function. Subsequently, immunohistochemical staining to identify the expression of c-Fos and NGF in the central micturition areas was performed. Ingestion of caffeine increased bladder smooth muscle contraction pressure and time as determined by cystometry. Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine. The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine. These results suggest that caffeine facilitates bladder instability through enhancing neuronal activation in the central micturition areas.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25323389</pmid><doi>10.3892/mmr.2014.2646</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Bladder c-Fos c-Fos protein Caffeine Caffeine - pharmacology central micturition center Female Females Genetic aspects Muscle contraction Muscle Contraction - drug effects Muscle Contraction - genetics Muscle, Smooth - drug effects Nerve growth factor Nerve Growth Factor - genetics neuronal activation Periaqueductal gray area Physiological aspects Preoptic area Pressure Proto-Oncogene Proteins c-fos - genetics Rats Rats, Sprague-Dawley Risk factors Rodents Smooth muscle Studies Urinary bladder Urinary Bladder - drug effects Urination Urination - drug effects Urination - genetics Urine Urodynamics - drug effects Urodynamics - genetics Urogenital system |
| title | Caffeine enhances micturition through neuronal activation in micturition centers |
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