HPA-Axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls
1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors. 2. Challenge probes with D,L fenfluramine ha...
Gespeichert in:
| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1991, Vol.15 (6), p.781-790 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 790 |
|---|---|
| container_issue | 6 |
| container_start_page | 781 |
| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
| container_volume | 15 |
| creator | Maes, Michael D'hondt, Peter Suy, Eduard Minner, Bob Vandervorst, Carine Raus, Jef |
| description | 1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors.
2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed.
3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist.
4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), B endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values.
5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other. |
| doi_str_mv | 10.1016/0278-5846(91)90007-N |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16153445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>027858469190007N</els_id><sourcerecordid>16153445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-4e59536fd7179d1b60944f2dd00ae306bb51f752894b2f0ebf95f4bb532fd7c33</originalsourceid><addsrcrecordid>eNp9kF1LHDEUhoO02K31H1iYiyLtxdRk8jGbm8IifhREvWivQyY5YaMzyZpki_57s53F3vUq8J7nPeQ8CJ0Q_J1gIs5w1y9bvmTiqyTfJMa4b28P0IIsa8w6It6hxRvyAX3M-aEyhGJ6iA6JEB3DdIEer-9X7erZ52Yd0xQD5EYH22xSHLUpPjQJ8iaGXPMSGwvPJcXWQXDjNunJB2gqY2FTsQy1p4uHUOYla9BjWb80JobaGvMn9N7pMcPx_j1Cvy8vfp1ftzd3Vz_PVzetYaQvLQMuORXO9qSXlgwCS8ZcZy3GGigWw8CJ63m3lGzoHIbBSe5YTWlXO4bSI3Q6761XPG0hFzX5bGAcdYC4zYoIwiljvIJsBk2KOSdwapP8pNOLIljtHKudQLUTqCRRfx2r21r7vN-_HSaw_0qz1Dr_sp_rbPTokg7G5zeM445gISv2Y8aguvjjIalsqjwD1icwRdno__-PV5SDmZk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16153445</pqid></control><display><type>article</type><title>HPA-Axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Maes, Michael ; D'hondt, Peter ; Suy, Eduard ; Minner, Bob ; Vandervorst, Carine ; Raus, Jef</creator><creatorcontrib>Maes, Michael ; D'hondt, Peter ; Suy, Eduard ; Minner, Bob ; Vandervorst, Carine ; Raus, Jef</creatorcontrib><description>1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors.
2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed.
3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist.
4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), B endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values.
5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/0278-5846(91)90007-N</identifier><identifier>PMID: 1662403</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adrenocorticotropic Hormone - blood ; Biological and medical sciences ; Brain Chemistry - drug effects ; D-fenfluramine ; depression ; Depressive Disorder - blood ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Dexamethasone ; dexamethasone suppression test ; Endorphins - blood ; Fenfluramine - adverse effects ; Fenfluramine - therapeutic use ; Hormones - blood ; Humans ; Hypothalamo-Hypophyseal System - physiology ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Pituitary-Adrenal System - physiology ; Prolactin - blood ; Psychiatric Status Rating Scales ; serotonergic probes ; Serotonin - physiology ; Serotoninergic system ; Stereoisomerism ; tryptophan ; Tryptophan - metabolism</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 1991, Vol.15 (6), p.781-790</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4e59536fd7179d1b60944f2dd00ae306bb51f752894b2f0ebf95f4bb532fd7c33</citedby><cites>FETCH-LOGICAL-c417t-4e59536fd7179d1b60944f2dd00ae306bb51f752894b2f0ebf95f4bb532fd7c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0278-5846(91)90007-N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5021069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1662403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>D'hondt, Peter</creatorcontrib><creatorcontrib>Suy, Eduard</creatorcontrib><creatorcontrib>Minner, Bob</creatorcontrib><creatorcontrib>Vandervorst, Carine</creatorcontrib><creatorcontrib>Raus, Jef</creatorcontrib><title>HPA-Axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors.
2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed.
3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist.
4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), B endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values.
5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other.</description><subject>Adrenocorticotropic Hormone - blood</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>D-fenfluramine</subject><subject>depression</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Dexamethasone</subject><subject>dexamethasone suppression test</subject><subject>Endorphins - blood</subject><subject>Fenfluramine - adverse effects</subject><subject>Fenfluramine - therapeutic use</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Prolactin - blood</subject><subject>Psychiatric Status Rating Scales</subject><subject>serotonergic probes</subject><subject>Serotonin - physiology</subject><subject>Serotoninergic system</subject><subject>Stereoisomerism</subject><subject>tryptophan</subject><subject>Tryptophan - metabolism</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LHDEUhoO02K31H1iYiyLtxdRk8jGbm8IifhREvWivQyY5YaMzyZpki_57s53F3vUq8J7nPeQ8CJ0Q_J1gIs5w1y9bvmTiqyTfJMa4b28P0IIsa8w6It6hxRvyAX3M-aEyhGJ6iA6JEB3DdIEer-9X7erZ52Yd0xQD5EYH22xSHLUpPjQJ8iaGXPMSGwvPJcXWQXDjNunJB2gqY2FTsQy1p4uHUOYla9BjWb80JobaGvMn9N7pMcPx_j1Cvy8vfp1ftzd3Vz_PVzetYaQvLQMuORXO9qSXlgwCS8ZcZy3GGigWw8CJ63m3lGzoHIbBSe5YTWlXO4bSI3Q6761XPG0hFzX5bGAcdYC4zYoIwiljvIJsBk2KOSdwapP8pNOLIljtHKudQLUTqCRRfx2r21r7vN-_HSaw_0qz1Dr_sp_rbPTokg7G5zeM445gISv2Y8aguvjjIalsqjwD1icwRdno__-PV5SDmZk</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Maes, Michael</creator><creator>D'hondt, Peter</creator><creator>Suy, Eduard</creator><creator>Minner, Bob</creator><creator>Vandervorst, Carine</creator><creator>Raus, Jef</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>1991</creationdate><title>HPA-Axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls</title><author>Maes, Michael ; D'hondt, Peter ; Suy, Eduard ; Minner, Bob ; Vandervorst, Carine ; Raus, Jef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4e59536fd7179d1b60944f2dd00ae306bb51f752894b2f0ebf95f4bb532fd7c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenocorticotropic Hormone - blood</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>D-fenfluramine</topic><topic>depression</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - psychology</topic><topic>Dexamethasone</topic><topic>dexamethasone suppression test</topic><topic>Endorphins - blood</topic><topic>Fenfluramine - adverse effects</topic><topic>Fenfluramine - therapeutic use</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Prolactin - blood</topic><topic>Psychiatric Status Rating Scales</topic><topic>serotonergic probes</topic><topic>Serotonin - physiology</topic><topic>Serotoninergic system</topic><topic>Stereoisomerism</topic><topic>tryptophan</topic><topic>Tryptophan - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>D'hondt, Peter</creatorcontrib><creatorcontrib>Suy, Eduard</creatorcontrib><creatorcontrib>Minner, Bob</creatorcontrib><creatorcontrib>Vandervorst, Carine</creatorcontrib><creatorcontrib>Raus, Jef</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maes, Michael</au><au>D'hondt, Peter</au><au>Suy, Eduard</au><au>Minner, Bob</au><au>Vandervorst, Carine</au><au>Raus, Jef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HPA-Axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>1991</date><risdate>1991</risdate><volume>15</volume><issue>6</issue><spage>781</spage><epage>790</epage><pages>781-790</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors.
2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed.
3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist.
4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), B endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values.
5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1662403</pmid><doi>10.1016/0278-5846(91)90007-N</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-5846 |
| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 1991, Vol.15 (6), p.781-790 |
| issn | 0278-5846 1878-4216 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16153445 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenocorticotropic Hormone - blood Biological and medical sciences Brain Chemistry - drug effects D-fenfluramine depression Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - psychology Dexamethasone dexamethasone suppression test Endorphins - blood Fenfluramine - adverse effects Fenfluramine - therapeutic use Hormones - blood Humans Hypothalamo-Hypophyseal System - physiology Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pituitary-Adrenal System - physiology Prolactin - blood Psychiatric Status Rating Scales serotonergic probes Serotonin - physiology Serotoninergic system Stereoisomerism tryptophan Tryptophan - metabolism |
| title | HPA-Axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T05%3A32%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HPA-Axis%20hormones%20and%20prolactin%20responses%20to%20dextro-fenfluramine%20in%20depressed%20patients%20and%20healthy%20controls&rft.jtitle=Progress%20in%20neuro-psychopharmacology%20&%20biological%20psychiatry&rft.au=Maes,%20Michael&rft.date=1991&rft.volume=15&rft.issue=6&rft.spage=781&rft.epage=790&rft.pages=781-790&rft.issn=0278-5846&rft.eissn=1878-4216&rft.coden=PNPPD7&rft_id=info:doi/10.1016/0278-5846(91)90007-N&rft_dat=%3Cproquest_cross%3E16153445%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16153445&rft_id=info:pmid/1662403&rft_els_id=027858469190007N&rfr_iscdi=true |