Interaction of Azoles with Rifampin, Phenytoin, and Carbamazepine: In Vitro and Clinical Observations

Twelve patients receiving therapy with an azole agent (ketoconazole, itraconazole, and/or fluconazole) for systemic mycoses experienced drug interactions with rifampin, phenytoin, and/or carbamazepine resulting in substantial decreases in azole concentrations in serum. All four patients receiving az...

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Veröffentlicht in:	Clinical infectious diseases 1992-01, Vol.14 (1), p.165-174
Hauptverfasser:	Tucker, Richard M., Denning, David W., Hanson, Linda H., Rinaldi, Michael G., Graybill, John R., Sharkey, P. Kay, Pappagianis, Demosthenes, Stevens, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antifungal Agents - pharmacokinetics Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antifungals Azoles Azoles - pharmacokinetics Azoles - pharmacology Azoles - therapeutic use Carbamazepine - pharmacology Carbamazepine - therapeutic use Clinical Infectious Disease Articles Coccidioides - drug effects Coccidioides immitis Coccidioidomycosis Cryptococcosis Cryptococcus neoformans Cryptococcus neoformans - drug effects Cyclosporins Drug Interactions Drug Therapy, Combination Female Fluconazole - pharmacokinetics Fluconazole - pharmacology Fluconazole - therapeutic use Fungal infections Humans Itraconazole Ketoconazole - analogs & derivatives Ketoconazole - pharmacokinetics Ketoconazole - pharmacology Ketoconazole - therapeutic use Malassezia - drug effects Male Medication administration Middle Aged Mycoses - drug therapy Phenytoin - pharmacology Phenytoin - therapeutic use Rifampin - pharmacology Rifampin - therapeutic use Seborrheic dermatitis Yeasts
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