The deficiency of Gαq leads to enhanced T‐cell survival

We have previously reported that Gαq, the α subunit of the Gq protein, had important roles in dendritic cell migration, B‐cell survival and autoimmunity. In this study, we showed that the deficiency of Gαq led to enhanced T‐cell survival. Cultured Gnaq−/− T cells exhibited survival advantages both i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology and cell biology 2014-10, Vol.92 (9), p.781-790
Hauptverfasser:	Wang, Dashan, Zhang, Yugao, He, Yan, Li, Yan, Lund, Frances E, Shi, Guixiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death - genetics Cell Death - immunology Cell Survival - genetics Cell Survival - immunology Down-Regulation - genetics Down-Regulation - immunology Fas Ligand Protein - genetics Fas Ligand Protein - immunology GTP-Binding Protein alpha Subunits, Gq-G11 - genetics GTP-Binding Protein alpha Subunits, Gq-G11 - immunology Interleukin-2 - genetics Interleukin-2 - immunology Interleukin-7 - genetics Interleukin-7 - immunology Mice Mice, Inbred C57BL Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T-Lymphocytes - immunology Up-Regulation - genetics Up-Regulation - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!