Blockade of CD26 Signaling Inhibits Human Osteoclast Development

Bone remodeling is maintained by the delicate balance between osteoblasts (OBs) and osteoclasts (OCs). However, the role of CD26 in regulating bone remodeling has not yet been characterized. We herein show that CD26 is preferentially expressed on normal human OCs and is intensely expressed on activa...

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Veröffentlicht in:	Journal of bone and mineral research 2014-11, Vol.29 (11), p.2439-2455
Hauptverfasser:	Nishida, Hiroko, Suzuki, Hiroshi, Madokoro, Hiroko, Hayashi, Mutsumi, Morimoto, Chikao, Sakamoto, Michiie, Yamada, Taketo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized - pharmacology bone resorption CD26 Cells, Cultured Dipeptidyl Peptidase 4 - metabolism Gene Expression Regulation - drug effects Humans MAP Kinase Kinase 3 - metabolism MAP Kinase Kinase 6 - metabolism MAP Kinase Signaling System - drug effects osteoclast osteoclast precursor Osteoclasts - cytology Osteoclasts - metabolism p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism RANK Ligand - metabolism
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