Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy
Background Toll‐like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T‐cell driven immune‐mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approa...
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| Veröffentlicht in: | International journal of dermatology 2014-11, Vol.53 (11), p.e512-e517 |
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| container_title | International journal of dermatology |
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| creator | Kondelkova, Katerina Krejsek, Jan Borska, Lenka Fiala, Zdenek Hamakova, Kveta Ettler, Karel Andrys, Ctirad |
| description | Background
Toll‐like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T‐cell driven immune‐mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to assess both the kinetics of the expression of TLR2 on blood cells and the concentration of soluble (s)TLR2 in serum of patients with psoriasis and to examine the effect of GT on both TLR2 expression and sTLR2 level.
Methods
Both membrane and sTLR2 were determined in 20 patients and 20 healthy controls. sTLR2 was evaluated by enzyme‐linked immunosorbent assay. Flow cytometry method was used to determine the expression of membrane TLR2 of monocytes and granulocytes.
Results
The serum level of sTLR2 was significantly lower (P |
| doi_str_mv | 10.1111/ijd.12381 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1614700229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1614700229</sourcerecordid><originalsourceid>FETCH-LOGICAL-i2891-1036e43c4a76274d6aa04756e0e283d6c4e4cb0ae16d2edebbf6e28f5d9db63d3</originalsourceid><addsrcrecordid>eNo9kMtOAzEMRSMEoqWw4AdQlmyG5jWZzhIVKEU8NiCWUTJx1bSZB0mq0r9noIA3tnXPteSL0DklV7SvsVvZK8r4hB6gIeUyz4Tk7BANCaE0K0leDtBJjKt-5YyKYzRgOZOSEzZE5glqE3QDWDcWx9ZvjAf82nqfebcGHKCCLrUBM-wa3OnkoEkRb11a4i62wenoIk4BdAKLzQ7PWqjWEGrd4LSEoLvdKTpaaB_h7LeP0Nvd7ev0Pnt8mc2n14-ZY5OSZpRwCYJXQheSFcJKrYkocgkE2IRbWQkQlSEaqLQMLBizkL2yyG1pjeSWj9Dl_m4X2o8NxKRqFyvwvv-u3URFJRUFIYyVPXrxi25MDVZ1wdU67NRfLj0w3gNb52H3r1OivgNXfeDqJ3A1f7j5GXpHtne4mODz36HDWsmCF7l6f56p2RN7LiY3pZryL6JOgis</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1614700229</pqid></control><display><type>article</type><title>Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kondelkova, Katerina ; Krejsek, Jan ; Borska, Lenka ; Fiala, Zdenek ; Hamakova, Kveta ; Ettler, Karel ; Andrys, Ctirad</creator><creatorcontrib>Kondelkova, Katerina ; Krejsek, Jan ; Borska, Lenka ; Fiala, Zdenek ; Hamakova, Kveta ; Ettler, Karel ; Andrys, Ctirad</creatorcontrib><description>Background
Toll‐like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T‐cell driven immune‐mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to assess both the kinetics of the expression of TLR2 on blood cells and the concentration of soluble (s)TLR2 in serum of patients with psoriasis and to examine the effect of GT on both TLR2 expression and sTLR2 level.
Methods
Both membrane and sTLR2 were determined in 20 patients and 20 healthy controls. sTLR2 was evaluated by enzyme‐linked immunosorbent assay. Flow cytometry method was used to determine the expression of membrane TLR2 of monocytes and granulocytes.
Results
The serum level of sTLR2 was significantly lower (P < 0.0001) in patients both before and after GT compared to the control group. Compared to the membrane expression of TLR2 on monocytes of healthy blood donors, TLR2 expression was significantly higher in patients both before and after GT (P = 0.0001). Similarly, TLR2 expression on granulocytes was significantly higher in patients both before (P = 0.0061) and after (P < 0.0001) therapy than in control.
Conclusions
Membrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.12381</identifier><identifier>PMID: 25266302</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Case-Control Studies ; Cell Membrane - chemistry ; Coal Tar - therapeutic use ; Female ; Granulocytes - chemistry ; Healthy Volunteers ; Humans ; Keratolytic Agents - therapeutic use ; Male ; Middle Aged ; Monocytes - chemistry ; Photochemotherapy ; Psoriasis - blood ; Psoriasis - drug therapy ; Toll-Like Receptor 2 - analysis ; Toll-Like Receptor 2 - blood ; Ultraviolet Therapy ; Young Adult</subject><ispartof>International journal of dermatology, 2014-11, Vol.53 (11), p.e512-e517</ispartof><rights>2014 The International Society of Dermatology</rights><rights>2014 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.12381$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.12381$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25266302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondelkova, Katerina</creatorcontrib><creatorcontrib>Krejsek, Jan</creatorcontrib><creatorcontrib>Borska, Lenka</creatorcontrib><creatorcontrib>Fiala, Zdenek</creatorcontrib><creatorcontrib>Hamakova, Kveta</creatorcontrib><creatorcontrib>Ettler, Karel</creatorcontrib><creatorcontrib>Andrys, Ctirad</creatorcontrib><title>Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Toll‐like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T‐cell driven immune‐mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to assess both the kinetics of the expression of TLR2 on blood cells and the concentration of soluble (s)TLR2 in serum of patients with psoriasis and to examine the effect of GT on both TLR2 expression and sTLR2 level.
Methods
Both membrane and sTLR2 were determined in 20 patients and 20 healthy controls. sTLR2 was evaluated by enzyme‐linked immunosorbent assay. Flow cytometry method was used to determine the expression of membrane TLR2 of monocytes and granulocytes.
Results
The serum level of sTLR2 was significantly lower (P < 0.0001) in patients both before and after GT compared to the control group. Compared to the membrane expression of TLR2 on monocytes of healthy blood donors, TLR2 expression was significantly higher in patients both before and after GT (P = 0.0001). Similarly, TLR2 expression on granulocytes was significantly higher in patients both before (P = 0.0061) and after (P < 0.0001) therapy than in control.
Conclusions
Membrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cell Membrane - chemistry</subject><subject>Coal Tar - therapeutic use</subject><subject>Female</subject><subject>Granulocytes - chemistry</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Keratolytic Agents - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - chemistry</subject><subject>Photochemotherapy</subject><subject>Psoriasis - blood</subject><subject>Psoriasis - drug therapy</subject><subject>Toll-Like Receptor 2 - analysis</subject><subject>Toll-Like Receptor 2 - blood</subject><subject>Ultraviolet Therapy</subject><subject>Young Adult</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOAzEMRSMEoqWw4AdQlmyG5jWZzhIVKEU8NiCWUTJx1bSZB0mq0r9noIA3tnXPteSL0DklV7SvsVvZK8r4hB6gIeUyz4Tk7BANCaE0K0leDtBJjKt-5YyKYzRgOZOSEzZE5glqE3QDWDcWx9ZvjAf82nqfebcGHKCCLrUBM-wa3OnkoEkRb11a4i62wenoIk4BdAKLzQ7PWqjWEGrd4LSEoLvdKTpaaB_h7LeP0Nvd7ev0Pnt8mc2n14-ZY5OSZpRwCYJXQheSFcJKrYkocgkE2IRbWQkQlSEaqLQMLBizkL2yyG1pjeSWj9Dl_m4X2o8NxKRqFyvwvv-u3URFJRUFIYyVPXrxi25MDVZ1wdU67NRfLj0w3gNb52H3r1OivgNXfeDqJ3A1f7j5GXpHtne4mODz36HDWsmCF7l6f56p2RN7LiY3pZryL6JOgis</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Kondelkova, Katerina</creator><creator>Krejsek, Jan</creator><creator>Borska, Lenka</creator><creator>Fiala, Zdenek</creator><creator>Hamakova, Kveta</creator><creator>Ettler, Karel</creator><creator>Andrys, Ctirad</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy</title><author>Kondelkova, Katerina ; Krejsek, Jan ; Borska, Lenka ; Fiala, Zdenek ; Hamakova, Kveta ; Ettler, Karel ; Andrys, Ctirad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2891-1036e43c4a76274d6aa04756e0e283d6c4e4cb0ae16d2edebbf6e28f5d9db63d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cell Membrane - chemistry</topic><topic>Coal Tar - therapeutic use</topic><topic>Female</topic><topic>Granulocytes - chemistry</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Keratolytic Agents - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - chemistry</topic><topic>Photochemotherapy</topic><topic>Psoriasis - blood</topic><topic>Psoriasis - drug therapy</topic><topic>Toll-Like Receptor 2 - analysis</topic><topic>Toll-Like Receptor 2 - blood</topic><topic>Ultraviolet Therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondelkova, Katerina</creatorcontrib><creatorcontrib>Krejsek, Jan</creatorcontrib><creatorcontrib>Borska, Lenka</creatorcontrib><creatorcontrib>Fiala, Zdenek</creatorcontrib><creatorcontrib>Hamakova, Kveta</creatorcontrib><creatorcontrib>Ettler, Karel</creatorcontrib><creatorcontrib>Andrys, Ctirad</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondelkova, Katerina</au><au>Krejsek, Jan</au><au>Borska, Lenka</au><au>Fiala, Zdenek</au><au>Hamakova, Kveta</au><au>Ettler, Karel</au><au>Andrys, Ctirad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2014-11</date><risdate>2014</risdate><volume>53</volume><issue>11</issue><spage>e512</spage><epage>e517</epage><pages>e512-e517</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Toll‐like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T‐cell driven immune‐mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to assess both the kinetics of the expression of TLR2 on blood cells and the concentration of soluble (s)TLR2 in serum of patients with psoriasis and to examine the effect of GT on both TLR2 expression and sTLR2 level.
Methods
Both membrane and sTLR2 were determined in 20 patients and 20 healthy controls. sTLR2 was evaluated by enzyme‐linked immunosorbent assay. Flow cytometry method was used to determine the expression of membrane TLR2 of monocytes and granulocytes.
Results
The serum level of sTLR2 was significantly lower (P < 0.0001) in patients both before and after GT compared to the control group. Compared to the membrane expression of TLR2 on monocytes of healthy blood donors, TLR2 expression was significantly higher in patients both before and after GT (P = 0.0001). Similarly, TLR2 expression on granulocytes was significantly higher in patients both before (P = 0.0061) and after (P < 0.0001) therapy than in control.
Conclusions
Membrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25266302</pmid><doi>10.1111/ijd.12381</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Case-Control Studies Cell Membrane - chemistry Coal Tar - therapeutic use Female Granulocytes - chemistry Healthy Volunteers Humans Keratolytic Agents - therapeutic use Male Middle Aged Monocytes - chemistry Photochemotherapy Psoriasis - blood Psoriasis - drug therapy Toll-Like Receptor 2 - analysis Toll-Like Receptor 2 - blood Ultraviolet Therapy Young Adult |
| title | Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy |
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