Different pharmacokinetic and pharmacodynamic properties of recombinant follicle-stimulating hormone (rFSH) derived from a human cell line compared with rFSH from a non-human cell line

Pharmacokinetic and pharmacodynamic properties of a novel recombinant follicle‐stimulating hormone (rFSH) preparation (FE 999049), expressed by a human cell line (PER.C6), was compared with an rFSH preparation (follitropin α) expressed by a Chinese hamster ovary (CHO) cell line in healthy pituitary‐...

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Veröffentlicht in:	Journal of clinical pharmacology 2014-11, Vol.54 (11), p.1299-1307
Hauptverfasser:	Olsson, Håkan, Sandström, Rikard, Grundemar, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals bioavailability Cell Line CHO Cells Cricetinae Cricetulus Cross-Over Studies Female Follicle Stimulating Hormone - genetics Follicle Stimulating Hormone - metabolism Follicle Stimulating Hormone - pharmacokinetics Follicle Stimulating Hormone, Human - genetics Follicle Stimulating Hormone, Human - metabolism Follicle Stimulating Hormone, Human - pharmacokinetics human cell line Humans pharmacodynamics pharmacokinetics recombinant FSH Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacokinetics Rodents Species Specificity Young Adult
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