Occupational asthma caused by α-amylase inhalation: Clinical and immunologic findings and bronchial response patterns
Inhalation of dust from different enzymes can be the cause of occupational asthma in exposed workers, α-Amylase, derived from Aspergillus oryzae, is one of these enzymes, although there are few studies in the medical literature that refer to its allergologic properties and to clinical studies in sen...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1992, Vol.89 (1), p.118-125 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Losada, Eloy Hinojosa, Miguel Quirce, Santiago Sánchez-Cano, Moisés Moneo, Ignacio |
| description | Inhalation of dust from different enzymes can be the cause of occupational asthma in exposed workers, α-Amylase, derived from
Aspergillus oryzae, is one of these enzymes, although there are few studies in the medical literature that refer to its allergologic properties and to clinical studies in sensitized patients. The results obtained in a study performed in 83 pharmaceutical-industry workers exposed to powdered α-amylase are described in this article. The existence of sensitization to this enzyme was demonstrated in 26 of the workers by positive skin tests. Specific IgE values were significantly higher in workers with positive skin tests than in workers with negative skin tests (
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| doi_str_mv | 10.1016/S0091-6749(05)80048-X |
| format | Article |
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Aspergillus oryzae, is one of these enzymes, although there are few studies in the medical literature that refer to its allergologic properties and to clinical studies in sensitized patients. The results obtained in a study performed in 83 pharmaceutical-industry workers exposed to powdered α-amylase are described in this article. The existence of sensitization to this enzyme was demonstrated in 26 of the workers by positive skin tests. Specific IgE values were significantly higher in workers with positive skin tests than in workers with negative skin tests (
p<0.001). The bronchial provocation test with α-amylase was positive in six of the 14 patients challenged, and only immediate bronchial responses were observed; the same type of response was obtained by nasal provocation. One of the workers had a positive response to oral provocation with this enzyme, presenting abdominal, skin, and respiratory symptoms a few minutes after ingestion. Consequently, we consider that the bronchial asthma presented by the workers was due to an immediate-type, IgE-dependent, immunologic mechanism.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/S0091-6749(05)80048-X</identifier><identifier>PMID: 1730831</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Air Pollutants, Occupational - adverse effects ; Air Pollutants, Occupational - immunology ; Allergic diseases ; alpha-Amylases - adverse effects ; alpha-Amylases - immunology ; Aspergillus oryzae ; Asthma - etiology ; Biological and medical sciences ; bronchial provocation test ; Bronchial Provocation Tests ; enzymes ; Female ; Humans ; Immunoglobulin E - analysis ; Immunoglobulin G - analysis ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; occupational asthma ; Occupational Diseases - etiology ; Respiratory and ent allergic diseases ; Skin Tests ; α-Amylase</subject><ispartof>Journal of allergy and clinical immunology, 1992, Vol.89 (1), p.118-125</ispartof><rights>1992 Mosby-Year Book, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-9b6466ce22310d54ab39bf685ce257a753b4fa983371a8536bdfa2deb1e185253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009167490580048X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5107638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1730831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Losada, Eloy</creatorcontrib><creatorcontrib>Hinojosa, Miguel</creatorcontrib><creatorcontrib>Quirce, Santiago</creatorcontrib><creatorcontrib>Sánchez-Cano, Moisés</creatorcontrib><creatorcontrib>Moneo, Ignacio</creatorcontrib><title>Occupational asthma caused by α-amylase inhalation: Clinical and immunologic findings and bronchial response patterns</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Inhalation of dust from different enzymes can be the cause of occupational asthma in exposed workers, α-Amylase, derived from
Aspergillus oryzae, is one of these enzymes, although there are few studies in the medical literature that refer to its allergologic properties and to clinical studies in sensitized patients. The results obtained in a study performed in 83 pharmaceutical-industry workers exposed to powdered α-amylase are described in this article. The existence of sensitization to this enzyme was demonstrated in 26 of the workers by positive skin tests. Specific IgE values were significantly higher in workers with positive skin tests than in workers with negative skin tests (
p<0.001). The bronchial provocation test with α-amylase was positive in six of the 14 patients challenged, and only immediate bronchial responses were observed; the same type of response was obtained by nasal provocation. One of the workers had a positive response to oral provocation with this enzyme, presenting abdominal, skin, and respiratory symptoms a few minutes after ingestion. Consequently, we consider that the bronchial asthma presented by the workers was due to an immediate-type, IgE-dependent, immunologic mechanism.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - adverse effects</subject><subject>Air Pollutants, Occupational - immunology</subject><subject>Allergic diseases</subject><subject>alpha-Amylases - adverse effects</subject><subject>alpha-Amylases - immunology</subject><subject>Aspergillus oryzae</subject><subject>Asthma - etiology</subject><subject>Biological and medical sciences</subject><subject>bronchial provocation test</subject><subject>Bronchial Provocation Tests</subject><subject>enzymes</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>occupational asthma</subject><subject>Occupational Diseases - etiology</subject><subject>Respiratory and ent allergic diseases</subject><subject>Skin Tests</subject><subject>α-Amylase</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu1DAUhi0EKtPCI1TKAiG6CNhx7DhsKjTiJlXqApC6s47tk45RYg92UmkeixfhmfBcVJasLPv__nOsj5BLRt8yyuS7b5T2rJZd27-h4kpR2qr67glZMdp3tVSNeEpWj8hzcp7zT1ruXPVn5Ix1nCrOVuTh1tplC7OPAcYK8ryZoLKwZHSV2VV_ftcw7UbIWPmwgfEAvq_Wow_e7gvBVX6alhDHeO9tNfjgfLjPh8CkGOzGFyxh3sZQhpRNM6aQX5BnA4wZX57OC_Lj08fv6y_1ze3nr-sPN7XlXMx1b2QrpcWm4Yw60YLhvRmkEuVJdNAJbtoBesV5x0AJLo0boHFoGDIlGsEvyOvj3G2KvxbMs558tjiOEDAuWTPJWtY2tIDiCNoUc0446G3yE6SdZlTvfeuDb72XqanQB9_6rvQuTwsWM6H71zoKLvmrUw65CBsSBOvzIyYY7SRXBbs-YlhkPHhMOluPwaLzCe2sXfT_-chffBSfQw</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Losada, Eloy</creator><creator>Hinojosa, Miguel</creator><creator>Quirce, Santiago</creator><creator>Sánchez-Cano, Moisés</creator><creator>Moneo, Ignacio</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>1992</creationdate><title>Occupational asthma caused by α-amylase inhalation: Clinical and immunologic findings and bronchial response patterns</title><author>Losada, Eloy ; Hinojosa, Miguel ; Quirce, Santiago ; Sánchez-Cano, Moisés ; Moneo, Ignacio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-9b6466ce22310d54ab39bf685ce257a753b4fa983371a8536bdfa2deb1e185253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Air Pollutants, Occupational - adverse effects</topic><topic>Air Pollutants, Occupational - immunology</topic><topic>Allergic diseases</topic><topic>alpha-Amylases - adverse effects</topic><topic>alpha-Amylases - immunology</topic><topic>Aspergillus oryzae</topic><topic>Asthma - etiology</topic><topic>Biological and medical sciences</topic><topic>bronchial provocation test</topic><topic>Bronchial Provocation Tests</topic><topic>enzymes</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>occupational asthma</topic><topic>Occupational Diseases - etiology</topic><topic>Respiratory and ent allergic diseases</topic><topic>Skin Tests</topic><topic>α-Amylase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Losada, Eloy</creatorcontrib><creatorcontrib>Hinojosa, Miguel</creatorcontrib><creatorcontrib>Quirce, Santiago</creatorcontrib><creatorcontrib>Sánchez-Cano, Moisés</creatorcontrib><creatorcontrib>Moneo, Ignacio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Losada, Eloy</au><au>Hinojosa, Miguel</au><au>Quirce, Santiago</au><au>Sánchez-Cano, Moisés</au><au>Moneo, Ignacio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occupational asthma caused by α-amylase inhalation: Clinical and immunologic findings and bronchial response patterns</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1992</date><risdate>1992</risdate><volume>89</volume><issue>1</issue><spage>118</spage><epage>125</epage><pages>118-125</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Inhalation of dust from different enzymes can be the cause of occupational asthma in exposed workers, α-Amylase, derived from
Aspergillus oryzae, is one of these enzymes, although there are few studies in the medical literature that refer to its allergologic properties and to clinical studies in sensitized patients. The results obtained in a study performed in 83 pharmaceutical-industry workers exposed to powdered α-amylase are described in this article. The existence of sensitization to this enzyme was demonstrated in 26 of the workers by positive skin tests. Specific IgE values were significantly higher in workers with positive skin tests than in workers with negative skin tests (
p<0.001). The bronchial provocation test with α-amylase was positive in six of the 14 patients challenged, and only immediate bronchial responses were observed; the same type of response was obtained by nasal provocation. One of the workers had a positive response to oral provocation with this enzyme, presenting abdominal, skin, and respiratory symptoms a few minutes after ingestion. Consequently, we consider that the bronchial asthma presented by the workers was due to an immediate-type, IgE-dependent, immunologic mechanism.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>1730831</pmid><doi>10.1016/S0091-6749(05)80048-X</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Air Pollutants, Occupational - adverse effects Air Pollutants, Occupational - immunology Allergic diseases alpha-Amylases - adverse effects alpha-Amylases - immunology Aspergillus oryzae Asthma - etiology Biological and medical sciences bronchial provocation test Bronchial Provocation Tests enzymes Female Humans Immunoglobulin E - analysis Immunoglobulin G - analysis Immunopathology Male Medical sciences Middle Aged occupational asthma Occupational Diseases - etiology Respiratory and ent allergic diseases Skin Tests α-Amylase |
| title | Occupational asthma caused by α-amylase inhalation: Clinical and immunologic findings and bronchial response patterns |
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