Autoimmune cytopenias in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to...
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| Veröffentlicht in: | American journal of hematology 2014-11, Vol.89 (11), p.1055-1062 |
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| creator | Visco, Carlo Barcellini, Wilma Maura, Francesco Neri, Antonino Cortelezzi, Agostino Rodeghiero, Francesco |
| description | Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. Hematol. 89:1055–1062, 2014. © 2014 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ajh.23785 |
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The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. 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The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. Hematol. 89:1055–1062, 2014. © 2014 Wiley Periodicals, Inc.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Agranulocytosis - blood</subject><subject>Agranulocytosis - diagnosis</subject><subject>Agranulocytosis - etiology</subject><subject>Agranulocytosis - therapy</subject><subject>Anemia, Hemolytic, Autoimmune - blood</subject><subject>Anemia, Hemolytic, Autoimmune - diagnosis</subject><subject>Anemia, Hemolytic, Autoimmune - etiology</subject><subject>Anemia, Hemolytic, Autoimmune - therapy</subject><subject>Antigen Presentation</subject><subject>Autoantibodies - immunology</subject><subject>Blood Cells - immunology</subject><subject>Blood Component Transfusion</subject><subject>Clone Cells - immunology</subject><subject>Combined Modality Therapy</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - complications</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - immunology</subject><subject>Models, Immunological</subject><subject>Neoplastic Stem Cells - immunology</subject><subject>Paraneoplastic Syndromes - blood</subject><subject>Paraneoplastic Syndromes - diagnosis</subject><subject>Paraneoplastic Syndromes - etiology</subject><subject>Paraneoplastic Syndromes - therapy</subject><subject>Prognosis</subject><subject>Purpura, Thrombocytopenic, Idiopathic - blood</subject><subject>Purpura, Thrombocytopenic, Idiopathic - diagnosis</subject><subject>Purpura, Thrombocytopenic, Idiopathic - etiology</subject><subject>Purpura, Thrombocytopenic, Idiopathic - therapy</subject><subject>Receptors, Antigen, B-Cell - immunology</subject><subject>Red-Cell Aplasia, Pure - blood</subject><subject>Red-Cell Aplasia, Pure - diagnosis</subject><subject>Red-Cell Aplasia, Pure - etiology</subject><subject>Red-Cell Aplasia, Pure - therapy</subject><subject>Risk Factors</subject><subject>Splenectomy</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9LwzAUB_AgipvTg_-ADLzooVte0rwmxzH8ycCLnkOWpqyzbWqzIv3v7ez0IHh6D96HL48vIZdAZ0Apm5vtZsZ4IsURGQNVGEkU7JiMKUfod6pG5CyELaUAsaSnZMRiBUwyGBOxaHc-L8u2clPb7XztqtyEaV5N7abxVW6nRVfWG9_f9rtr312Zm3NykpkiuIvDnJC3-7vX5WO0enl4Wi5WkRUqFhEkijHh4jVFi5jKDDPLFBqepdwC0pQlNGOpk7GUYKRAjBPkMkttyjFZcz4hN0Nu3fiP1oWdLvNgXVGYyvk2aEDgSgAq7On1H7r1bVP13-0VAy4wgV7dDso2PoTGZbpu8tI0nQaq913qvkv93WVvrw6J7bp06a_8Ka8H8wF85oXr_k_Si-fHIfILuU17pQ</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Visco, Carlo</creator><creator>Barcellini, Wilma</creator><creator>Maura, Francesco</creator><creator>Neri, Antonino</creator><creator>Cortelezzi, Agostino</creator><creator>Rodeghiero, Francesco</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Autoimmune cytopenias in chronic lymphocytic leukemia</title><author>Visco, Carlo ; Barcellini, Wilma ; Maura, Francesco ; Neri, Antonino ; Cortelezzi, Agostino ; Rodeghiero, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5945-179225e4b06c66d8f6fc296a3fd3c160d270f2de84881a856647638fdcd367b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Agranulocytosis - blood</topic><topic>Agranulocytosis - diagnosis</topic><topic>Agranulocytosis - etiology</topic><topic>Agranulocytosis - therapy</topic><topic>Anemia, Hemolytic, Autoimmune - blood</topic><topic>Anemia, Hemolytic, Autoimmune - diagnosis</topic><topic>Anemia, Hemolytic, Autoimmune - etiology</topic><topic>Anemia, Hemolytic, Autoimmune - therapy</topic><topic>Antigen Presentation</topic><topic>Autoantibodies - immunology</topic><topic>Blood Cells - immunology</topic><topic>Blood Component Transfusion</topic><topic>Clone Cells - immunology</topic><topic>Combined Modality Therapy</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin Heavy Chains - genetics</topic><topic>Immunoglobulin M - immunology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - complications</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - immunology</topic><topic>Models, Immunological</topic><topic>Neoplastic Stem Cells - immunology</topic><topic>Paraneoplastic Syndromes - blood</topic><topic>Paraneoplastic Syndromes - diagnosis</topic><topic>Paraneoplastic Syndromes - etiology</topic><topic>Paraneoplastic Syndromes - therapy</topic><topic>Prognosis</topic><topic>Purpura, Thrombocytopenic, Idiopathic - blood</topic><topic>Purpura, Thrombocytopenic, Idiopathic - diagnosis</topic><topic>Purpura, Thrombocytopenic, Idiopathic - etiology</topic><topic>Purpura, Thrombocytopenic, Idiopathic - therapy</topic><topic>Receptors, Antigen, B-Cell - immunology</topic><topic>Red-Cell Aplasia, Pure - blood</topic><topic>Red-Cell Aplasia, Pure - diagnosis</topic><topic>Red-Cell Aplasia, Pure - etiology</topic><topic>Red-Cell Aplasia, Pure - therapy</topic><topic>Risk Factors</topic><topic>Splenectomy</topic><topic>T-Lymphocyte Subsets - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visco, Carlo</creatorcontrib><creatorcontrib>Barcellini, Wilma</creatorcontrib><creatorcontrib>Maura, Francesco</creatorcontrib><creatorcontrib>Neri, Antonino</creatorcontrib><creatorcontrib>Cortelezzi, Agostino</creatorcontrib><creatorcontrib>Rodeghiero, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visco, Carlo</au><au>Barcellini, Wilma</au><au>Maura, Francesco</au><au>Neri, Antonino</au><au>Cortelezzi, Agostino</au><au>Rodeghiero, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmune cytopenias in chronic lymphocytic leukemia</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2014-11</date><risdate>2014</risdate><volume>89</volume><issue>11</issue><spage>1055</spage><epage>1062</epage><pages>1055-1062</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><abstract>Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. Hematol. 89:1055–1062, 2014. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24912821</pmid><doi>10.1002/ajh.23785</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal Cortex Hormones - therapeutic use Agranulocytosis - blood Agranulocytosis - diagnosis Agranulocytosis - etiology Agranulocytosis - therapy Anemia, Hemolytic, Autoimmune - blood Anemia, Hemolytic, Autoimmune - diagnosis Anemia, Hemolytic, Autoimmune - etiology Anemia, Hemolytic, Autoimmune - therapy Antigen Presentation Autoantibodies - immunology Blood Cells - immunology Blood Component Transfusion Clone Cells - immunology Combined Modality Therapy Hematology Humans Immunoglobulin G - immunology Immunoglobulin Heavy Chains - genetics Immunoglobulin M - immunology Immunosuppressive Agents - therapeutic use Leukemia, Lymphocytic, Chronic, B-Cell - complications Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - immunology Models, Immunological Neoplastic Stem Cells - immunology Paraneoplastic Syndromes - blood Paraneoplastic Syndromes - diagnosis Paraneoplastic Syndromes - etiology Paraneoplastic Syndromes - therapy Prognosis Purpura, Thrombocytopenic, Idiopathic - blood Purpura, Thrombocytopenic, Idiopathic - diagnosis Purpura, Thrombocytopenic, Idiopathic - etiology Purpura, Thrombocytopenic, Idiopathic - therapy Receptors, Antigen, B-Cell - immunology Red-Cell Aplasia, Pure - blood Red-Cell Aplasia, Pure - diagnosis Red-Cell Aplasia, Pure - etiology Red-Cell Aplasia, Pure - therapy Risk Factors Splenectomy T-Lymphocyte Subsets - immunology |
| title | Autoimmune cytopenias in chronic lymphocytic leukemia |
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