The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression
Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gast...
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| Veröffentlicht in: | Advances in medical sciences 2014-09, Vol.59 (2), p.221-226 |
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| creator | Jurkowska, Grażyna Piotrowska-Staworko, Grażyna Guzińska-Ustymowicz, Katarzyna Kemona, Andrzej Świdnicka-Siergiejko, Agnieszka Łaszewicz, Wiktor Dąbrowski, Andrzej |
| description | Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gastric expression of growth factors and serum gastrin concentrations.
We examined immunohistochemically gastric EGF and both receptors’ expression in: gastric cancer (GC; n=29), chronic gastritis with H. pylori infection (GHp+; n=40) before and after eradication and in patients without H. pylori infection (GHp−; n=42).
Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp− (p |
| doi_str_mv | 10.1016/j.advms.2014.01.006 |
| format | Article |
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We examined immunohistochemically gastric EGF and both receptors’ expression in: gastric cancer (GC; n=29), chronic gastritis with H. pylori infection (GHp+; n=40) before and after eradication and in patients without H. pylori infection (GHp−; n=42).
Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp− (p<0.05), but were similar to GC. After eradication, EGF and the receptor's expression significantly decreased in the gastric body. Both EGFR and c-erb-B2 expression in the antrum were still higher than in GHp− (p<0.05), and remained comparable to GC.
In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.</description><identifier>ISSN: 1896-1126</identifier><identifier>EISSN: 1898-4002</identifier><identifier>DOI: 10.1016/j.advms.2014.01.006</identifier><identifier>PMID: 25051417</identifier><language>eng</language><publisher>Netherlands: Elsevier Urban & Partner Sp. z o.o</publisher><subject>Aged ; Anti-Bacterial Agents - therapeutic use ; c-erB-2 protein ; Drug Therapy, Combination ; Epidermal growth factor ; Epidermal Growth Factor - metabolism ; Epidermal growth factor receptor ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastric Mucosa - microbiology ; Gastric Mucosa - pathology ; Gastritis - complications ; Gastritis - drug therapy ; Gastritis - metabolism ; Gastritis - microbiology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation, Neoplastic - drug effects ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter Infections - metabolism ; Helicobacter Infections - microbiology ; Helicobacter pylori - drug effects ; Helicobacter pylori - physiology ; Helicobacter pylori infection ; Host-Pathogen Interactions - drug effects ; Humans ; Male ; Middle Aged ; Receptor, Epidermal Growth Factor - metabolism ; Receptor, ErbB-2 - metabolism ; Stomach Neoplasms - complications ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology</subject><ispartof>Advances in medical sciences, 2014-09, Vol.59 (2), p.221-226</ispartof><rights>2014 Medical University of Bialystok</rights><rights>Copyright © 2014 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-fca871412f4a7644ea2938285ff6aec94d78b1535aa2f7c68e2e9ef6075ff23d3</citedby><cites>FETCH-LOGICAL-c359t-fca871412f4a7644ea2938285ff6aec94d78b1535aa2f7c68e2e9ef6075ff23d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25051417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jurkowska, Grażyna</creatorcontrib><creatorcontrib>Piotrowska-Staworko, Grażyna</creatorcontrib><creatorcontrib>Guzińska-Ustymowicz, Katarzyna</creatorcontrib><creatorcontrib>Kemona, Andrzej</creatorcontrib><creatorcontrib>Świdnicka-Siergiejko, Agnieszka</creatorcontrib><creatorcontrib>Łaszewicz, Wiktor</creatorcontrib><creatorcontrib>Dąbrowski, Andrzej</creatorcontrib><title>The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression</title><title>Advances in medical sciences</title><addtitle>Adv Med Sci</addtitle><description>Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gastric expression of growth factors and serum gastrin concentrations.
We examined immunohistochemically gastric EGF and both receptors’ expression in: gastric cancer (GC; n=29), chronic gastritis with H. pylori infection (GHp+; n=40) before and after eradication and in patients without H. pylori infection (GHp−; n=42).
Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp− (p<0.05), but were similar to GC. After eradication, EGF and the receptor's expression significantly decreased in the gastric body. Both EGFR and c-erb-B2 expression in the antrum were still higher than in GHp− (p<0.05), and remained comparable to GC.
In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.</description><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>c-erB-2 protein</subject><subject>Drug Therapy, Combination</subject><subject>Epidermal growth factor</subject><subject>Epidermal Growth Factor - metabolism</subject><subject>Epidermal growth factor receptor</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - microbiology</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis - complications</subject><subject>Gastritis - drug therapy</subject><subject>Gastritis - metabolism</subject><subject>Gastritis - microbiology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - metabolism</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori - drug effects</subject><subject>Helicobacter pylori - physiology</subject><subject>Helicobacter pylori infection</subject><subject>Host-Pathogen Interactions - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Stomach Neoplasms - complications</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><issn>1896-1126</issn><issn>1898-4002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwC5CQR4Ym2E7iJAMDVP1AqsRAmS3XOQtXSRzstKL_HrcFRhbbJz2v7-5B6JaSmBLKHzaxrHaNjxmhaUxoTAg_Q0NalEWUEsLOj28eUcr4AF15vwkA44RcogHLSEZTmg_R2-oDsGk6qXpsNV5AbZRdhwoc7va1dQbbFk_ns_HhwA4UdL11YyzbCvchqyJw6-iZYfjqHHhvbHuNLrSsPdz83CP0PpuuJoto-Tp_mTwtI5VkZR9pJYs8TMF0KnOepiBZmRSsyLTmElSZVnmxplmSScl0rngBDErQnOSBYEmVjND96d_O2c8t-F40xiuoa9mC3XpBOU3KjJAkD2hyQpWz3jvQonOmkW4vKBEHm2IjjjbFwaYgVARZIXX302C7bqD6y_zqC8DjCYCw5s6AE14ZaBVUJpjqRWXNvw2-AU9ZhPQ</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Jurkowska, Grażyna</creator><creator>Piotrowska-Staworko, Grażyna</creator><creator>Guzińska-Ustymowicz, Katarzyna</creator><creator>Kemona, Andrzej</creator><creator>Świdnicka-Siergiejko, Agnieszka</creator><creator>Łaszewicz, Wiktor</creator><creator>Dąbrowski, Andrzej</creator><general>Elsevier Urban & Partner Sp. z o.o</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression</title><author>Jurkowska, Grażyna ; Piotrowska-Staworko, Grażyna ; Guzińska-Ustymowicz, Katarzyna ; Kemona, Andrzej ; Świdnicka-Siergiejko, Agnieszka ; Łaszewicz, Wiktor ; Dąbrowski, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-fca871412f4a7644ea2938285ff6aec94d78b1535aa2f7c68e2e9ef6075ff23d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>c-erB-2 protein</topic><topic>Drug Therapy, Combination</topic><topic>Epidermal growth factor</topic><topic>Epidermal Growth Factor - metabolism</topic><topic>Epidermal growth factor receptor</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - microbiology</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis - complications</topic><topic>Gastritis - drug therapy</topic><topic>Gastritis - metabolism</topic><topic>Gastritis - microbiology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - metabolism</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori - drug effects</topic><topic>Helicobacter pylori - physiology</topic><topic>Helicobacter pylori infection</topic><topic>Host-Pathogen Interactions - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Stomach Neoplasms - complications</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - microbiology</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jurkowska, Grażyna</creatorcontrib><creatorcontrib>Piotrowska-Staworko, Grażyna</creatorcontrib><creatorcontrib>Guzińska-Ustymowicz, Katarzyna</creatorcontrib><creatorcontrib>Kemona, Andrzej</creatorcontrib><creatorcontrib>Świdnicka-Siergiejko, Agnieszka</creatorcontrib><creatorcontrib>Łaszewicz, Wiktor</creatorcontrib><creatorcontrib>Dąbrowski, Andrzej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jurkowska, Grażyna</au><au>Piotrowska-Staworko, Grażyna</au><au>Guzińska-Ustymowicz, Katarzyna</au><au>Kemona, Andrzej</au><au>Świdnicka-Siergiejko, Agnieszka</au><au>Łaszewicz, Wiktor</au><au>Dąbrowski, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression</atitle><jtitle>Advances in medical sciences</jtitle><addtitle>Adv Med Sci</addtitle><date>2014-09</date><risdate>2014</risdate><volume>59</volume><issue>2</issue><spage>221</spage><epage>226</epage><pages>221-226</pages><issn>1896-1126</issn><eissn>1898-4002</eissn><abstract>Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gastric expression of growth factors and serum gastrin concentrations.
We examined immunohistochemically gastric EGF and both receptors’ expression in: gastric cancer (GC; n=29), chronic gastritis with H. pylori infection (GHp+; n=40) before and after eradication and in patients without H. pylori infection (GHp−; n=42).
Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp− (p<0.05), but were similar to GC. After eradication, EGF and the receptor's expression significantly decreased in the gastric body. Both EGFR and c-erb-B2 expression in the antrum were still higher than in GHp− (p<0.05), and remained comparable to GC.
In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.</abstract><cop>Netherlands</cop><pub>Elsevier Urban & Partner Sp. z o.o</pub><pmid>25051417</pmid><doi>10.1016/j.advms.2014.01.006</doi><tpages>6</tpages></addata></record> |
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| ispartof | Advances in medical sciences, 2014-09, Vol.59 (2), p.221-226 |
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| language | eng |
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| subjects | Aged Anti-Bacterial Agents - therapeutic use c-erB-2 protein Drug Therapy, Combination Epidermal growth factor Epidermal Growth Factor - metabolism Epidermal growth factor receptor Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - microbiology Gastric Mucosa - pathology Gastritis - complications Gastritis - drug therapy Gastritis - metabolism Gastritis - microbiology Gene Expression Regulation - drug effects Gene Expression Regulation, Neoplastic - drug effects Helicobacter Infections - complications Helicobacter Infections - drug therapy Helicobacter Infections - metabolism Helicobacter Infections - microbiology Helicobacter pylori - drug effects Helicobacter pylori - physiology Helicobacter pylori infection Host-Pathogen Interactions - drug effects Humans Male Middle Aged Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Stomach Neoplasms - complications Stomach Neoplasms - metabolism Stomach Neoplasms - microbiology Stomach Neoplasms - pathology |
| title | The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression |
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