Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells

Chibby (Cby) inhibits Wnt/β-catenin-mediated transcriptional activation by competing with Lef-1 (the transcription factor and target of β-catenin) to bind to β-catenin. This suggests that Cby could be a tumor suppressor protein. In the present study, we examined Cby expression in laryngeal squamous...

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Veröffentlicht in:	Oncology reports 2014-11, Vol.32 (5), p.1947-1956
Hauptverfasser:	XU, JUE, REN, GANG, ZHAO, DE-AN, LI, BO-AN, CAI, CHENG-FU, ZHOU, YI, LUO, XIAN-YANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Apoptosis Cancer Cancer therapies Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell cycle Cell growth Chibby Cyclin D1 - metabolism Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Hep G2 Cells Humans Kinases Laryngeal cancer Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology laryngeal squamous cell carcinoma Male Middle Aged Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology, Experimental Phase transitions Physiological aspects Protein expression signaling pathway Squamous cell carcinoma Studies Transcription factors Wnt Wnt Signaling Pathway
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