Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study
Objective To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. Design A prospective case control, record linkage study. Participants 2428 adults with MHI and an equal number of community controls (CC) were case-matched for age, gend...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2014-11, Vol.85 (11), p.1214-1220 |
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| creator | McMillan, T M Weir, C J Wainman-Lefley, J |
| description | Objective To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. Design A prospective case control, record linkage study. Participants 2428 adults with MHI and an equal number of community controls (CC) were case-matched for age, gender and social deprivation. A further control group admitted with a non-head injury was in addition matched for duration of hospital admission. Controls with a history of head injury prior to study entry were excluded. Main outcome measures Death or survival 15 years poststudy entry. Results Mortality per 1000 per year after MHI (24.49; 95% CI 23.21 to 25.79) was higher than in CC (13.34; 95% CI 12.29 to 14.44; p |
| doi_str_mv | 10.1136/jnnp-2013-307279 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1613941681</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4023942331</sourcerecordid><originalsourceid>FETCH-LOGICAL-b433t-5c8535e9dee9d09297160b78efcbdde72fd798f84920a92d61a439523cd47d253</originalsourceid><addsrcrecordid>eNqFkc1q3TAQhUVoSW7S7rMKgmwCwYl-bMvKrlyStpDSTQrdCdkac2Vsy5HkFO-aRV-0T1KZm3TRTQfEMOg7hxkOQqeUXFHKy-tuHKeMEcozTgQT8gBtaF5WGefk-xu0IYSx9FOQI3QcQkfWquQhOmJ5ybiQ-QY9f3E-6t7GBevR4MH52pp1osXvn78W0D5g3UbweOfCZBOKtRlsCNaN-IeNOzzY3uAdaIPt2M1-ucEaTz7B0ET7BLjRAbLGjdG7vgeDJzfNvY6rPsTZLO_Q21b3Ad6_9BP07e72Yfspu__68fP2w31W55zHrGiqghcgDaRHJJOClqQWFbRNbQwI1hohq7bKJSNaMlNSnXNZMN6YXBhW8BN0sfdNyz3OEKJKZzTQ93oENwdFS8plTsuKJvT8H7Rzsx_TdoqKirKCclEmiuypJl0bPLRq8nbQflGUqDUetcaj1njUPp4kOXsxnusBzF_Bax4JuNwD9dD93-4Ptm2cAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781251376</pqid></control><display><type>article</type><title>Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>McMillan, T M ; Weir, C J ; Wainman-Lefley, J</creator><creatorcontrib>McMillan, T M ; Weir, C J ; Wainman-Lefley, J</creatorcontrib><description>Objective To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. Design A prospective case control, record linkage study. Participants 2428 adults with MHI and an equal number of community controls (CC) were case-matched for age, gender and social deprivation. A further control group admitted with a non-head injury was in addition matched for duration of hospital admission. Controls with a history of head injury prior to study entry were excluded. Main outcome measures Death or survival 15 years poststudy entry. Results Mortality per 1000 per year after MHI (24.49; 95% CI 23.21 to 25.79) was higher than in CC (13.34; 95% CI 12.29 to 14.44; p<0.0001) or ‘other injury’ controls (OIC) (19.63; 95% CI 18.43 to 20.87; p<0.0001). Age at injury was important: younger adults (15–54 years) with MHI had a 4.2-fold greater risk of death than CC; in adults aged over 54, the risk was 1.4 times higher. Gender and social deprivation showed a similar association with death in the MHI and control groups. Repeated head injury was a risk factor for death in the MHI group. The frequency of hospital admission with systemic disease preinjury and postinjury was higher in both injury groups than in CC and higher in MHI than OIC. Prospective data in the MHI group suggest an association between preinjury lifestyle and mortality. Causes of death after MHI were similar to those of the control groups. Conclusions Adults hospitalised with MHI had greater risk of death in the following 15 years than matched controls. The extent to which lifestyle and potential chronic changes in neuropathology explain these findings is unclear. Lifestyle factors do contribute to risk of death after MHI and this finding has implications for lifestyle management interventions.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp-2013-307279</identifier><identifier>PMID: 24623794</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cardiovascular disease ; Case-Control Studies ; Cause of Death ; Chronic illnesses ; Craniocerebral Trauma - mortality ; Dementia ; Female ; Gender ; Head injuries ; Hospitalization - statistics & numerical data ; Hospitals ; Humans ; Kaplan-Meier Estimate ; Life Style ; Lifestyles ; Male ; Middle Aged ; Mortality ; Neuropathology ; Population ; Prospective Studies ; Risk Factors ; Sex ; Socioeconomic Factors ; Sports injuries ; Studies ; Young Adult</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2014-11, Vol.85 (11), p.1214-1220</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b433t-5c8535e9dee9d09297160b78efcbdde72fd798f84920a92d61a439523cd47d253</citedby><cites>FETCH-LOGICAL-b433t-5c8535e9dee9d09297160b78efcbdde72fd798f84920a92d61a439523cd47d253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/85/11/1214.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/85/11/1214.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24623794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McMillan, T M</creatorcontrib><creatorcontrib>Weir, C J</creatorcontrib><creatorcontrib>Wainman-Lefley, J</creatorcontrib><title>Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Objective To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. Design A prospective case control, record linkage study. Participants 2428 adults with MHI and an equal number of community controls (CC) were case-matched for age, gender and social deprivation. A further control group admitted with a non-head injury was in addition matched for duration of hospital admission. Controls with a history of head injury prior to study entry were excluded. Main outcome measures Death or survival 15 years poststudy entry. Results Mortality per 1000 per year after MHI (24.49; 95% CI 23.21 to 25.79) was higher than in CC (13.34; 95% CI 12.29 to 14.44; p<0.0001) or ‘other injury’ controls (OIC) (19.63; 95% CI 18.43 to 20.87; p<0.0001). Age at injury was important: younger adults (15–54 years) with MHI had a 4.2-fold greater risk of death than CC; in adults aged over 54, the risk was 1.4 times higher. Gender and social deprivation showed a similar association with death in the MHI and control groups. Repeated head injury was a risk factor for death in the MHI group. The frequency of hospital admission with systemic disease preinjury and postinjury was higher in both injury groups than in CC and higher in MHI than OIC. Prospective data in the MHI group suggest an association between preinjury lifestyle and mortality. Causes of death after MHI were similar to those of the control groups. Conclusions Adults hospitalised with MHI had greater risk of death in the following 15 years than matched controls. The extent to which lifestyle and potential chronic changes in neuropathology explain these findings is unclear. Lifestyle factors do contribute to risk of death after MHI and this finding has implications for lifestyle management interventions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Cause of Death</subject><subject>Chronic illnesses</subject><subject>Craniocerebral Trauma - mortality</subject><subject>Dementia</subject><subject>Female</subject><subject>Gender</subject><subject>Head injuries</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neuropathology</subject><subject>Population</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex</subject><subject>Socioeconomic Factors</subject><subject>Sports injuries</subject><subject>Studies</subject><subject>Young Adult</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1q3TAQhUVoSW7S7rMKgmwCwYl-bMvKrlyStpDSTQrdCdkac2Vsy5HkFO-aRV-0T1KZm3TRTQfEMOg7hxkOQqeUXFHKy-tuHKeMEcozTgQT8gBtaF5WGefk-xu0IYSx9FOQI3QcQkfWquQhOmJ5ybiQ-QY9f3E-6t7GBevR4MH52pp1osXvn78W0D5g3UbweOfCZBOKtRlsCNaN-IeNOzzY3uAdaIPt2M1-ucEaTz7B0ET7BLjRAbLGjdG7vgeDJzfNvY6rPsTZLO_Q21b3Ad6_9BP07e72Yfspu__68fP2w31W55zHrGiqghcgDaRHJJOClqQWFbRNbQwI1hohq7bKJSNaMlNSnXNZMN6YXBhW8BN0sfdNyz3OEKJKZzTQ93oENwdFS8plTsuKJvT8H7Rzsx_TdoqKirKCclEmiuypJl0bPLRq8nbQflGUqDUetcaj1njUPp4kOXsxnusBzF_Bax4JuNwD9dD93-4Ptm2cAw</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>McMillan, T M</creator><creator>Weir, C J</creator><creator>Wainman-Lefley, J</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study</title><author>McMillan, T M ; Weir, C J ; Wainman-Lefley, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b433t-5c8535e9dee9d09297160b78efcbdde72fd798f84920a92d61a439523cd47d253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Cause of Death</topic><topic>Chronic illnesses</topic><topic>Craniocerebral Trauma - mortality</topic><topic>Dementia</topic><topic>Female</topic><topic>Gender</topic><topic>Head injuries</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Life Style</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neuropathology</topic><topic>Population</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex</topic><topic>Socioeconomic Factors</topic><topic>Sports injuries</topic><topic>Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McMillan, T M</creatorcontrib><creatorcontrib>Weir, C J</creatorcontrib><creatorcontrib>Wainman-Lefley, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McMillan, T M</au><au>Weir, C J</au><au>Wainman-Lefley, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2014-11</date><risdate>2014</risdate><volume>85</volume><issue>11</issue><spage>1214</spage><epage>1220</epage><pages>1214-1220</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Objective To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. Design A prospective case control, record linkage study. Participants 2428 adults with MHI and an equal number of community controls (CC) were case-matched for age, gender and social deprivation. A further control group admitted with a non-head injury was in addition matched for duration of hospital admission. Controls with a history of head injury prior to study entry were excluded. Main outcome measures Death or survival 15 years poststudy entry. Results Mortality per 1000 per year after MHI (24.49; 95% CI 23.21 to 25.79) was higher than in CC (13.34; 95% CI 12.29 to 14.44; p<0.0001) or ‘other injury’ controls (OIC) (19.63; 95% CI 18.43 to 20.87; p<0.0001). Age at injury was important: younger adults (15–54 years) with MHI had a 4.2-fold greater risk of death than CC; in adults aged over 54, the risk was 1.4 times higher. Gender and social deprivation showed a similar association with death in the MHI and control groups. Repeated head injury was a risk factor for death in the MHI group. The frequency of hospital admission with systemic disease preinjury and postinjury was higher in both injury groups than in CC and higher in MHI than OIC. Prospective data in the MHI group suggest an association between preinjury lifestyle and mortality. Causes of death after MHI were similar to those of the control groups. Conclusions Adults hospitalised with MHI had greater risk of death in the following 15 years than matched controls. The extent to which lifestyle and potential chronic changes in neuropathology explain these findings is unclear. Lifestyle factors do contribute to risk of death after MHI and this finding has implications for lifestyle management interventions.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>24623794</pmid><doi>10.1136/jnnp-2013-307279</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Cardiovascular disease Case-Control Studies Cause of Death Chronic illnesses Craniocerebral Trauma - mortality Dementia Female Gender Head injuries Hospitalization - statistics & numerical data Hospitals Humans Kaplan-Meier Estimate Life Style Lifestyles Male Middle Aged Mortality Neuropathology Population Prospective Studies Risk Factors Sex Socioeconomic Factors Sports injuries Studies Young Adult |
| title | Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study |
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