Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment
Background Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem. Methods The histopathological features of 51 tissue specimens fro...
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| Veröffentlicht in: | Head & neck 2014-11, Vol.36 (11), p.1611-1618 |
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| creator | Panizza, Benedict Warren, Timothy A. Solares, C. Arturo Boyle, Glen M. Lambie, Duncan Brown, Ian |
| description | Background
Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.
Methods
The histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections.
Results
No skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion.
Conclusion
Perineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1611–1618, 2014 |
| doi_str_mv | 10.1002/hed.23509 |
| format | Article |
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Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.
Methods
The histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections.
Results
No skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion.
Conclusion
Perineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1611–1618, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23509</identifier><identifier>PMID: 24115192</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Cohort Studies ; Cranial Nerves - pathology ; Female ; head and neck neoplasms ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - secondary ; Head and Neck Neoplasms - surgery ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; perineurium ; peripheral nerve neoplastic infiltration ; Peripheral Nerves - pathology ; Peripheral Nervous System Neoplasms - pathology ; Prognosis ; Retrospective Studies ; skin cancer ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck ; Tissue Embedding</subject><ispartof>Head & neck, 2014-11, Vol.36 (11), p.1611-1618</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4619-b48ad2f786fe86e197b8d4590d70c32d2a6b16a0b668a3855bea6b58b1c2e5473</citedby><cites>FETCH-LOGICAL-c4619-b48ad2f786fe86e197b8d4590d70c32d2a6b16a0b668a3855bea6b58b1c2e5473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23509$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23509$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24115192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panizza, Benedict</creatorcontrib><creatorcontrib>Warren, Timothy A.</creatorcontrib><creatorcontrib>Solares, C. Arturo</creatorcontrib><creatorcontrib>Boyle, Glen M.</creatorcontrib><creatorcontrib>Lambie, Duncan</creatorcontrib><creatorcontrib>Brown, Ian</creatorcontrib><title>Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.
Methods
The histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections.
Results
No skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion.
Conclusion
Perineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1611–1618, 2014</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cohort Studies</subject><subject>Cranial Nerves - pathology</subject><subject>Female</subject><subject>head and neck neoplasms</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - secondary</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>perineurium</subject><subject>peripheral nerve neoplastic infiltration</subject><subject>Peripheral Nerves - pathology</subject><subject>Peripheral Nervous System Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>skin cancer</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Tissue Embedding</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1TAQhSMEoqWw4AWQJTawSOu_2MmSltKLdAULQLCzHGfCdZvYqe0AfRzeFOemlwUSKx_NfHM8o1MUzwk-JRjTsx10p5RVuHlQHBPcyBIzLh8umrOSYcmPiicxXmOMmeD0cXFEOSEVaehx8XtjY_KTTjs_-O_W6AH1oNMcICLfIzNYty9OEKyDOWRp3Q8drXf7_py0Az9HFG9nPS7CwDAgo4Oxzo96gdIO0A50h7TrkANzsxdLdfIJXLKL6TgN-aOUfSPqfUAp5DXG3H1aPOr1EOHZ_XtSfHl3-fliU24_Xr2_eLMtDRekKVte6472shY91AJII9u641WDO4kNox3VoiVC41aIWrO6qlrIlapuiaFQcclOiler7xT87QwxqdHG5Zj1QEUEYQ1rpGgy-vIf9NrPweXtFopSyeuKZer1SpngYwzQqynYUYc7RbBaclM5N7XPLbMv7h3ndszVA3kIKgNnK_DTDnD3fye1uXx7sCzXiRww_Po7ocONEpLJSn39cKW255tP2638pjD7A7h6s9I</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Panizza, Benedict</creator><creator>Warren, Timothy A.</creator><creator>Solares, C. Arturo</creator><creator>Boyle, Glen M.</creator><creator>Lambie, Duncan</creator><creator>Brown, Ian</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment</title><author>Panizza, Benedict ; Warren, Timothy A. ; Solares, C. Arturo ; Boyle, Glen M. ; Lambie, Duncan ; Brown, Ian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4619-b48ad2f786fe86e197b8d4590d70c32d2a6b16a0b668a3855bea6b58b1c2e5473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cohort Studies</topic><topic>Cranial Nerves - pathology</topic><topic>Female</topic><topic>head and neck neoplasms</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - secondary</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>perineurium</topic><topic>peripheral nerve neoplastic infiltration</topic><topic>Peripheral Nerves - pathology</topic><topic>Peripheral Nervous System Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>skin cancer</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Tissue Embedding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panizza, Benedict</creatorcontrib><creatorcontrib>Warren, Timothy A.</creatorcontrib><creatorcontrib>Solares, C. Arturo</creatorcontrib><creatorcontrib>Boyle, Glen M.</creatorcontrib><creatorcontrib>Lambie, Duncan</creatorcontrib><creatorcontrib>Brown, Ian</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panizza, Benedict</au><au>Warren, Timothy A.</au><au>Solares, C. Arturo</au><au>Boyle, Glen M.</au><au>Lambie, Duncan</au><au>Brown, Ian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-11</date><risdate>2014</risdate><volume>36</volume><issue>11</issue><spage>1611</spage><epage>1618</epage><pages>1611-1618</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.
Methods
The histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections.
Results
No skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion.
Conclusion
Perineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1611–1618, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24115192</pmid><doi>10.1002/hed.23509</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biopsy, Needle Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Cohort Studies Cranial Nerves - pathology Female head and neck neoplasms Head and Neck Neoplasms - pathology Head and Neck Neoplasms - secondary Head and Neck Neoplasms - surgery Humans Immunohistochemistry Male Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging perineurium peripheral nerve neoplastic infiltration Peripheral Nerves - pathology Peripheral Nervous System Neoplasms - pathology Prognosis Retrospective Studies skin cancer Skin Neoplasms - pathology Skin Neoplasms - surgery squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Tissue Embedding |
| title | Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment |
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