Testicular effects of the leydig cell toxicant ethane dimethanesulphonate given to neonatal rats

Neonatal rats were injected with either 50 mg/kg ethane dimethanesulphonate (EDS) or vehicle on days 1 to 5 inclusive or on day 1 alone. Studies were made on days 6, 28, and 63 of testicular structure; related endocrinologic parameters were measured in the day 1 to 5 treated animals only. Leydig cel...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1991, Vol.5 (6), p.497-504
Hauptverfasser:	Thomson, Simon D., Lendon, Roger G., Morris, Ian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - physiology Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Chorionic Gonadotropin - metabolism ethane dimethanesulphonate Follicle Stimulating Hormone - blood gonadotrophins growth Leydig cells Leydig Cells - drug effects Luteinizing Hormone - blood Male Medical sciences Mesylates - toxicity neonatal Organ Size - drug effects Radioimmunoassay rat Rats Rats, Inbred Strains Seminiferous Tubules - metabolism Seminiferous Tubules - pathology Spermatogenesis - drug effects Testicular Diseases - chemically induced Testicular Diseases - pathology testis Testis - pathology testosterone Testosterone - biosynthesis Testosterone - blood Toxicology Various organic compounds
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