Genetic correction of cultured T cells from an adenosine deaminase‐deficient patient: Characteristics of non‐transduced and transduced T cells

T lymphocytes derived from peripheral blood of a patient with adenosine deaminase (ADA) deficiency were expanded in vitro. The human ADA (hADA) gene was introduced into these replicating ADA− T cells with the use of an amphotropic recombinant retrovirus carrying the hADA gene. Subsequently, infected...

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Veröffentlicht in:	European journal of immunology 1992-01, Vol.22 (1), p.63-69
Hauptverfasser:	Braakman, Eric, Van Beusechem, Victor W., Van Krimpen, Brigitte A., Fischer, Alain, Bolhuis, Reinder L. H., Valerio, Dinko
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine deaminase Adenosine Deaminase - deficiency Adenosine Deaminase - genetics CD4 Antigens - analysis CD8 Antigens - analysis Cells, Cultured Genetic Therapy Humans immunodeficiency Infant Phenotype T-Lymphocytes - enzymology Transduction, Genetic
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