Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

Significance Prostate cancer often responds to hormone ablation therapy or chemotherapy by becoming more aggressive and metastatic. B cells recruited into hormone-deprived tumors by C-X-C motif chemokine 13 (CXCL13) play an important role in this process. We investigated how androgen ablation induce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (41), p.14776-14781
Hauptverfasser:	Ammirante, Massimo, Shalapour, Shabnam, Kang, Youngjin, Jamieson, Christina A. M., Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Androgens Androgens - pharmacology Animals B lymphocytes Biological Sciences Cancer Castration chemokine CXCL13 Chemokine CXCL13 - metabolism Chemotherapy Connective Tissue Growth Factor - metabolism Disease Progression drug therapy Fibroblasts Gene expression Humans Hypoxia Hypoxia - metabolism Hypoxia - pathology hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Insulin-Like Growth Factor I - metabolism Lymphocytes Male Messenger RNA metastasis Mice, Transgenic Myofibroblasts Myofibroblasts - drug effects Myofibroblasts - metabolism Myofibroblasts - pathology oxygen Phosphodiesterase 5 Inhibitors - pharmacology Prostate - drug effects Prostate - metabolism Prostate - pathology Prostate cancer prostatic neoplasms Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology Receptors, Tumor Necrosis Factor, Member 25 - metabolism Signal Transduction - drug effects Tissues transforming growth factor beta Transforming Growth Factor beta - metabolism Tumors
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