$Zebrafish Bioassay-Guided Microfractionation Identifies Anticonvulsant Steroid Glycosides from the Philippine Medicinal Plant Solanum torvum$

Zebrafish Bioassay-Guided Microfractionation Identifies Anticonvulsant Steroid Glycosides from the Philippine Medicinal Plant Solanum torvum

Medicinal plants used for the treatment of epilepsy are potentially a valuable source of novel antiepileptic small molecules. To identify anticonvulsant secondary metabolites, we performed an in vivo, zebrafish-based screen of medicinal plants used in Southeast Asia for the treatment of seizures. So...

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Veröffentlicht in:	ACS chemical neuroscience 2014-10, Vol.5 (10), p.993-1004
Hauptverfasser:	Challal, Soura, Buenafe, Olivia E. M, Queiroz, Emerson F, Maljevic, Snezana, Marcourt, Laurence, Bock, Merle, Kloeti, Werner, Dayrit, Fabian M, Harvey, Alan L, Lerche, Holger, Esguerra, Camila V, de Witte, Peter A. M, Wolfender, Jean-Luc, Crawford, Alexander D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - chemistry Anticonvulsants - pharmacology Biological Assay - methods Chemical Fractionation - methods Chromatography, High Pressure Liquid - methods Disease Models, Animal Drug Discovery - methods Glycosides - chemistry Glycosides - pharmacology Hydrolysis Larva Microtechnology - methods Molecular Structure Oocytes - drug effects Oocytes - metabolism Patch-Clamp Techniques Pentylenetetrazole Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Seizures - drug therapy Solanum - chemistry Xenopus laevis Zebrafish
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