Protective Effect of Ellagic Acid on Concanavalin A‑Induced Hepatitis via Toll-Like Receptor and Mitogen-Activated Protein Kinase/Nuclear Factor κB Signaling Pathways

Ellagic acid (EA) is present in certain fruits and nuts, including raspberries, pomegranates, and walnuts, and has anti-inflammatory and antioxidant properties. The aims of this study were to examine the protective effect of EA on concanavalin A (Con A)-induced hepatitis and to elucidate its underly...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2014-10, Vol.62 (41), p.10110-10117
Hauptverfasser:	Lee, Jae Hong, Won, Jong Hoon, Choi, Jong Min, Cha, Hye Hyeon, Jang, Yeo Jin, Park, Seohyeon, Kim, Han Gyeol, Kim, Hyung Chul, Kim, Dae Kyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant activity concanavalin A Concanavalin A - adverse effects ellagic acid Ellagic Acid - administration & dosage fruits hepatitis Hepatitis - drug therapy Hepatitis - etiology Humans interleukin-1beta interleukin-6 intravenous injection liver liver protein Male messenger RNA Mice Mice, Inbred BALB C mitogen-activated protein kinase Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism necrosis NF-kappa B - genetics NF-kappa B - metabolism oral administration phosphorylation Phosphorylation - drug effects pomegranates Protective Agents - administration & dosage protective effect raspberries signal transduction Signal Transduction - drug effects tissues Toll-like receptor 2 Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptor 4 Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism transcription factor NF-kappa B tumor necrosis factor-alpha walnuts
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