Effect of paracetamol on mitochondrial membrane function in rat liver slices

The effect of paracetamol on mitochondrial function was studied using rat liver slices. Changes in the potential of the mitochondrial and plasma membrane were monitored using [ 3H]-triphenylmethylphosphonium (TPMP +) and [ 14C]thiocyanate (SCN −) probes, respectively. Liver slices were exposed to 10...

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Veröffentlicht in:	Biochemical pharmacology 1991-07, Vol.42 (4), p.931-936
Hauptverfasser:	Nazareth, Wilhermina M.A., Sethi, Jaswinder K., McLean, Andre E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Animals Biological and medical sciences Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - physiology Cysteine - pharmacology Drug toxicity and drugs side effects treatment Intracellular Fluid - metabolism Intracellular Membranes - drug effects Intracellular Membranes - physiology Liver - anatomy & histology Liver - physiology Male Medical sciences Membrane Potentials - drug effects mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - physiology Onium Compounds - pharmacokinetics paracetamol Pharmacology. Drug treatments Pyridines - pharmacology Rats Rats, Inbred Strains Thiocyanates - pharmacokinetics Toxicity: digestive system Trityl Compounds - pharmacokinetics
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