DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase

Menadione (MD; 2-methyl-1,4-naphthoquinone), a redox cycling quinone was shown to induce single (ss)- and double (ds)-strand DNA breaks in human MCF-7 cells. This DNA damage was mediated via the hydroxyl radical as evidenced by electron spin resonance spectroscopy (ESR) studies utilizing the spin tr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1992-02, Vol.267 (4), p.2474-2479
Hauptverfasser:	Nutter, L M, Ngo, E O, Fisher, G R, Gutierrez, P L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Catalase - pharmacology Cell Survival - drug effects Cyclic N-Oxides - metabolism Dicumarol - pharmacology DNA - drug effects Electron Spin Resonance Spectroscopy Free Radicals General aspects Humans Medical sciences NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors NAD(P)H Dehydrogenase (Quinone) - metabolism Oxidation-Reduction Pharmacology. Drug treatments Spectrum Analysis Vitamin K - metabolism Vitamin K - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!