Molecular basis for a functionally unique cytochrome P450IIB1 variant

Liver microsomes from phenobarbital-treated rats of four inbred strains expressing distinct allelic variants of cytochrome P450IIB1 were analyzed. The Wistar Munich (WM) strain exhibited 5- to 10-fold lower androstenedione 16 beta-hydroxylase activity (a specific P450IIB1 marker) than the Lewis, Wis...

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Veröffentlicht in:	The Journal of biological chemistry 1991-11, Vol.266 (33), p.22515-22521
Hauptverfasser:	Kedzie, K M, Balfour, C A, Escobar, G Y, Grimm, S W, He, Y A, Pepperl, D J, Regan, J W, Stevens, J C, Halpert, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine Alleles Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cloning, Molecular Cytochrome P-450 CYP2B1 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - isolation & purification Cytochrome P-450 Enzyme System - metabolism cytochrome P450IIB1 DNA - genetics DNA - isolation & purification endoplasmic reticulum Fundamental and applied biological sciences. Psychology Genetic Variation Hemoproteins Kinetics Liver - enzymology Male Metalloproteins Microsomes, Liver - drug effects Microsomes, Liver - enzymology Oxidoreductases - genetics Oxidoreductases - isolation & purification Oxidoreductases - metabolism Phenobarbital - pharmacology Plasmids Proteins Rats Rats, Inbred Lew Rats, Inbred Strains Rats, Inbred WF Rats, Inbred WKY Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism RNA - genetics RNA - isolation & purification Sequence Homology, Nucleic Acid Species Specificity Steroid 16-alpha-Hydroxylase Substrate Specificity
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