Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes

CXCL14 is a chemokine that has previously been implicated in insulin resistance in mice. In humans, the role of CXCL14 in metabolic processes is not well established, and we sought to determine whether CXCL14 is a risk susceptibility gene important in fetal programming of metabolic disease. For this...

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Veröffentlicht in:	Journal of human genetics 2014-09, Vol.59 (9), p.504-511
Hauptverfasser:	Cheong, Clara Y, Chng, Keefe, Lim, Mei Kee, Amrithraj, Ajith I, Joseph, Roy, Sukarieh, Rami, Chee Tan, Yong, Chan, Louiza, Tan, Jun Hao, Chen, Li, Pan, Hong, Holbrook, Joanna D, Meaney, Michael J, Seng Chong, Yap, Gluckman, Peter D, Stünkel, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Caloric Restriction Cells, Cultured Chemokines Chemokines, CXC - genetics CpG islands CpG Islands - genetics DNA Methylation Female Fetuses Gene Expression Profiling Humans Infant, Low Birth Weight - metabolism Infant, Newborn Infants Insulin Low-birth-weight Macaca fascicularis Macaca fascicularis - genetics Male Maternal Age Mesenchymal Stromal Cells - metabolism Mesenchyme Metabolic disorders Metabolism Pregnancy Promoter Regions, Genetic - genetics Reverse Transcriptase Polymerase Chain Reaction Stem cell transplantation Stem cells Umbilical cord Umbilical Cord - cytology Umbilical Cord - metabolism
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